Direct Cyclization of 1,3‐Diketones with Malonate‐Based Iodonium Ylides to Generate Dihydrofurans Article Swipe
Related Concepts
Malonate
Chemistry
Medicinal chemistry
Diketone
Organic chemistry
Zhiguo Zhao
,
Ziqiang Zhao
,
Yuanling Pang
,
Yu‐Cheng Gu
,
Yao Wang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/chem.202404442
· OA: W4408162353
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/chem.202404442
· OA: W4408162353
While iodonium ylides are important reactants in a wide range of reactions, the exploration of electron‐transfer property of iodonium ylides remains an underdeveloped topic. Herein, we describe a direct cyclization of 1,3‐diketones with malonate‐based iodonium ylides to give a diverse array of dihydrofurans in moderate yields. The control experiments suggest that the electron transfer between enol and iodonium ylide gives reactive species, thus enabling a cyclization cascade process to take place to give dihydrofurans.
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