Direct Radical Scavenging Activity of Benzbromarone Provides Beneficial Antioxidant Properties for Hyperuricemia Treatment Article Swipe
Daisuke Kadowaki
,
Shoichi Sakaguchi
,
Yohei Miyamoto
,
Kazuaki Taguchi
,
Nanako Muraya
,
Yuki Narita
,
Keizo Sato
,
Victor Tuan Giam Chuang
,
Toru Maruyama
,
Masaki Otagiri
,
Sumío Hirata
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1248/bpb.b14-00514
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1248/bpb.b14-00514
Uric acid exerts an important antioxidant effect against external oxidative stress under physiological conditions. However, uric acid itself can increase oxidative stress via reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation in adipocytes and vascular cells. Uric acid transporter 1 is involved in the generation of this oxidative stress. Furthermore, uric acid locally activates the renin-angiotensin system, thus producing angiotensin II and subsequently increasing intracellular oxidative stress. Benzbromarone has been reported to suppress uric acid reabsorption via uric acid transporter 1 inhibition in renal tubular cells. In this study we evaluated the in vitro antioxidant effect of benzbromarone from several perspectives. First, the direct radical-trapping capacity of benzbromarone was measured by chemiluminescence assay and electron paramagnetic resonance spectroscopy. Second, the intracellular antioxidant activity of benzbromarone in hyperuricemia was evaluated using endothelial cells. In light of these results, benzbromarone is hypothesized directly to scavenge the superoxide anion radical. In addition, benzbromarone inhibited reactive oxygen species production that was induced by angiotensin II or uric acid in endothelial cells. These findings suggest that benzbromarone possesses the ability directly to scavenge radicals and may act as an antioxidant against uric acid and angiotensin II-induced oxidative stresses in endothelial cells at therapeutically achievable levels in blood.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1248/bpb.b14-00514
- https://www.jstage.jst.go.jp/article/bpb/38/3/38_b14-00514/_pdf
- OA Status
- diamond
- Cited By
- 38
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2036352098
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2036352098Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1248/bpb.b14-00514Digital Object Identifier
- Title
-
Direct Radical Scavenging Activity of Benzbromarone Provides Beneficial Antioxidant Properties for Hyperuricemia TreatmentWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-01-01Full publication date if available
- Authors
-
Daisuke Kadowaki, Shoichi Sakaguchi, Yohei Miyamoto, Kazuaki Taguchi, Nanako Muraya, Yuki Narita, Keizo Sato, Victor Tuan Giam Chuang, Toru Maruyama, Masaki Otagiri, Sumío HirataList of authors in order
- Landing page
-
https://doi.org/10.1248/bpb.b14-00514Publisher landing page
- PDF URL
-
https://www.jstage.jst.go.jp/article/bpb/38/3/38_b14-00514/_pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.jstage.jst.go.jp/article/bpb/38/3/38_b14-00514/_pdfDirect OA link when available
- Concepts
-
Benzbromarone, Hyperuricemia, Scavenging, Antioxidant, Chemistry, Pharmacology, Uric acid, Medicine, Traditional medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
38Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 6, 2023: 2, 2022: 2, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2036352098 |
|---|---|
| doi | https://doi.org/10.1248/bpb.b14-00514 |
| ids.doi | https://doi.org/10.1248/bpb.b14-00514 |
| ids.mag | 2036352098 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/25757933 |
| ids.openalex | https://openalex.org/W2036352098 |
| fwci | 2.2704918 |
| mesh[0].qualifier_ui | Q000494 |
| mesh[0].descriptor_ui | D000975 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | pharmacology |
| mesh[0].descriptor_name | Antioxidants |
| mesh[1].qualifier_ui | Q000627 |
| mesh[1].descriptor_ui | D000975 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | therapeutic use |
| mesh[1].descriptor_name | Antioxidants |
| mesh[2].qualifier_ui | Q000494 |
| mesh[2].descriptor_ui | D001553 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | pharmacology |
| mesh[2].descriptor_name | Benzbromarone |
| mesh[3].qualifier_ui | Q000627 |
| mesh[3].descriptor_ui | D001553 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | therapeutic use |
| mesh[3].descriptor_name | Benzbromarone |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D002460 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Cell Line |
| mesh[5].qualifier_ui | Q000187 |
| mesh[5].descriptor_ui | D042783 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | drug effects |
| mesh[5].descriptor_name | Endothelial Cells |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D042783 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Endothelial Cells |
| mesh[7].qualifier_ui | Q000494 |
| mesh[7].descriptor_ui | D016166 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | pharmacology |
| mesh[7].descriptor_name | Free Radical Scavengers |
| mesh[8].qualifier_ui | Q000627 |
| mesh[8].descriptor_ui | D016166 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | therapeutic use |
| mesh[8].descriptor_name | Free Radical Scavengers |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D061307 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Human Umbilical Vein Endothelial Cells |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D006801 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Humans |
| mesh[11].qualifier_ui | Q000097 |
| mesh[11].descriptor_ui | D033461 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | blood |
| mesh[11].descriptor_name | Hyperuricemia |
| mesh[12].qualifier_ui | Q000188 |
| mesh[12].descriptor_ui | D033461 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | drug therapy |
| mesh[12].descriptor_name | Hyperuricemia |
| mesh[13].qualifier_ui | Q000187 |
| mesh[13].descriptor_ui | D007668 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | drug effects |
| mesh[13].descriptor_name | Kidney |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D007668 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Kidney |
| mesh[15].qualifier_ui | Q000187 |
| mesh[15].descriptor_ui | D018384 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | drug effects |
| mesh[15].descriptor_name | Oxidative Stress |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D017382 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Reactive Oxygen Species |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D013481 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Superoxides |
| mesh[18].qualifier_ui | Q000097 |
| mesh[18].descriptor_ui | D014527 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | blood |
| mesh[18].descriptor_name | Uric Acid |
| mesh[19].qualifier_ui | Q000494 |
| mesh[19].descriptor_ui | D000975 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | pharmacology |
| mesh[19].descriptor_name | Antioxidants |
| mesh[20].qualifier_ui | Q000627 |
| mesh[20].descriptor_ui | D000975 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | therapeutic use |
| mesh[20].descriptor_name | Antioxidants |
| mesh[21].qualifier_ui | Q000494 |
| mesh[21].descriptor_ui | D001553 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | pharmacology |
| mesh[21].descriptor_name | Benzbromarone |
| mesh[22].qualifier_ui | Q000627 |
| mesh[22].descriptor_ui | D001553 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | therapeutic use |
| mesh[22].descriptor_name | Benzbromarone |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D002460 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Cell Line |
| mesh[24].qualifier_ui | Q000187 |
| mesh[24].descriptor_ui | D042783 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | drug effects |
| mesh[24].descriptor_name | Endothelial Cells |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D042783 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Endothelial Cells |
| mesh[26].qualifier_ui | Q000494 |
| mesh[26].descriptor_ui | D016166 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | pharmacology |
| mesh[26].descriptor_name | Free Radical Scavengers |
| mesh[27].qualifier_ui | Q000627 |
| mesh[27].descriptor_ui | D016166 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | therapeutic use |
| mesh[27].descriptor_name | Free Radical Scavengers |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D061307 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Human Umbilical Vein Endothelial Cells |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D006801 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Humans |
| mesh[30].qualifier_ui | Q000097 |
| mesh[30].descriptor_ui | D033461 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | blood |
| mesh[30].descriptor_name | Hyperuricemia |
| mesh[31].qualifier_ui | Q000188 |
| mesh[31].descriptor_ui | D033461 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | drug therapy |
| mesh[31].descriptor_name | Hyperuricemia |
| mesh[32].qualifier_ui | Q000187 |
| mesh[32].descriptor_ui | D007668 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | drug effects |
| mesh[32].descriptor_name | Kidney |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D007668 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Kidney |
| mesh[34].qualifier_ui | Q000187 |
| mesh[34].descriptor_ui | D018384 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | drug effects |
| mesh[34].descriptor_name | Oxidative Stress |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D017382 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | Reactive Oxygen Species |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D013481 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Superoxides |
| mesh[37].qualifier_ui | Q000097 |
| mesh[37].descriptor_ui | D014527 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | blood |
| mesh[37].descriptor_name | Uric Acid |
| type | article |
| title | Direct Radical Scavenging Activity of Benzbromarone Provides Beneficial Antioxidant Properties for Hyperuricemia Treatment |
| biblio.issue | 3 |
| biblio.volume | 38 |
| biblio.last_page | 492 |
| biblio.first_page | 487 |
| topics[0].id | https://openalex.org/T11139 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2727 |
| topics[0].subfield.display_name | Nephrology |
| topics[0].display_name | Gout, Hyperuricemia, Uric Acid |
| topics[1].id | https://openalex.org/T13878 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9799000024795532 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2746 |
| topics[1].subfield.display_name | Surgery |
| topics[1].display_name | Case Reports on Hematomas |
| topics[2].id | https://openalex.org/T12817 |
| topics[2].field.id | https://openalex.org/fields/30 |
| topics[2].field.display_name | Pharmacology, Toxicology and Pharmaceutics |
| topics[2].score | 0.9696000218391418 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/3004 |
| topics[2].subfield.display_name | Pharmacology |
| topics[2].display_name | Pharmacological Effects of Natural Compounds |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2780274859 |
| concepts[0].level | 4 |
| concepts[0].score | 0.918269157409668 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q410435 |
| concepts[0].display_name | Benzbromarone |
| concepts[1].id | https://openalex.org/C2779721657 |
| concepts[1].level | 3 |
| concepts[1].score | 0.8573497533798218 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q49970 |
| concepts[1].display_name | Hyperuricemia |
| concepts[2].id | https://openalex.org/C2777807096 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7887330651283264 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1285257 |
| concepts[2].display_name | Scavenging |
| concepts[3].id | https://openalex.org/C2778004101 |
| concepts[3].level | 2 |
| concepts[3].score | 0.7750742435455322 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q133948 |
| concepts[3].display_name | Antioxidant |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.5164077877998352 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C98274493 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4366433918476105 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[5].display_name | Pharmacology |
| concepts[6].id | https://openalex.org/C2779881121 |
| concepts[6].level | 2 |
| concepts[6].score | 0.3660237193107605 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q105522 |
| concepts[6].display_name | Uric acid |
| concepts[7].id | https://openalex.org/C71924100 |
| concepts[7].level | 0 |
| concepts[7].score | 0.3501136302947998 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[7].display_name | Medicine |
| concepts[8].id | https://openalex.org/C556039675 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3241119384765625 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q771035 |
| concepts[8].display_name | Traditional medicine |
| concepts[9].id | https://openalex.org/C55493867 |
| concepts[9].level | 1 |
| concepts[9].score | 0.2054244577884674 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[9].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/benzbromarone |
| keywords[0].score | 0.918269157409668 |
| keywords[0].display_name | Benzbromarone |
| keywords[1].id | https://openalex.org/keywords/hyperuricemia |
| keywords[1].score | 0.8573497533798218 |
| keywords[1].display_name | Hyperuricemia |
| keywords[2].id | https://openalex.org/keywords/scavenging |
| keywords[2].score | 0.7887330651283264 |
| keywords[2].display_name | Scavenging |
| keywords[3].id | https://openalex.org/keywords/antioxidant |
| keywords[3].score | 0.7750742435455322 |
| keywords[3].display_name | Antioxidant |
| keywords[4].id | https://openalex.org/keywords/chemistry |
| keywords[4].score | 0.5164077877998352 |
| keywords[4].display_name | Chemistry |
| keywords[5].id | https://openalex.org/keywords/pharmacology |
| keywords[5].score | 0.4366433918476105 |
| keywords[5].display_name | Pharmacology |
| keywords[6].id | https://openalex.org/keywords/uric-acid |
| keywords[6].score | 0.3660237193107605 |
| keywords[6].display_name | Uric acid |
| keywords[7].id | https://openalex.org/keywords/medicine |
| keywords[7].score | 0.3501136302947998 |
| keywords[7].display_name | Medicine |
| keywords[8].id | https://openalex.org/keywords/traditional-medicine |
| keywords[8].score | 0.3241119384765625 |
| keywords[8].display_name | Traditional medicine |
| keywords[9].id | https://openalex.org/keywords/biochemistry |
| keywords[9].score | 0.2054244577884674 |
| keywords[9].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1248/bpb.b14-00514 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S165235614 |
| locations[0].source.issn | 0918-6158, 1347-5215 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 0918-6158 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Biological and Pharmaceutical Bulletin |
| locations[0].source.host_organization | https://openalex.org/P4310313382 |
| locations[0].source.host_organization_name | Pharmaceutical Society of Japan |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310313382 |
| locations[0].license | |
| locations[0].pdf_url | https://www.jstage.jst.go.jp/article/bpb/38/3/38_b14-00514/_pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Biological & Pharmaceutical Bulletin |
| locations[0].landing_page_url | https://doi.org/10.1248/bpb.b14-00514 |
| locations[1].id | pmid:25757933 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Biological & pharmaceutical bulletin |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/25757933 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5020836697 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5166-7145 |
| authorships[0].author.display_name | Daisuke Kadowaki |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I96036126 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I96036126 |
| authorships[0].affiliations[1].raw_affiliation_string | Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[0].institutions[0].id | https://openalex.org/I96036126 |
| authorships[0].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Kumamoto University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Daisuke Kadowaki |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[1].author.id | https://openalex.org/A5079840751 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3650-1221 |
| authorships[1].author.display_name | Shoichi Sakaguchi |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I96036126 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[1].institutions[0].id | https://openalex.org/I96036126 |
| authorships[1].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Kumamoto University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Shoichi Sakaguchi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[2].author.id | https://openalex.org/A5109195984 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Yohei Miyamoto |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I96036126 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University |
| authorships[2].institutions[0].id | https://openalex.org/I96036126 |
| authorships[2].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Kumamoto University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yohei Miyamoto |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University |
| authorships[3].author.id | https://openalex.org/A5070210035 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-3575-0448 |
| authorships[3].author.display_name | Kazuaki Taguchi |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I96036126 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I181097317 |
| authorships[3].affiliations[1].raw_affiliation_string | Faculty of Pharmaceutical Sciences, Sojo University |
| authorships[3].institutions[0].id | https://openalex.org/I96036126 |
| authorships[3].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Kumamoto University |
| authorships[3].institutions[1].id | https://openalex.org/I181097317 |
| authorships[3].institutions[1].ror | https://ror.org/014fz7968 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I181097317 |
| authorships[3].institutions[1].country_code | JP |
| authorships[3].institutions[1].display_name | Sojo University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Kazuaki Taguchi |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Faculty of Pharmaceutical Sciences, Sojo University |
| authorships[4].author.id | https://openalex.org/A5016652518 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Nanako Muraya |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I96036126 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[4].institutions[0].id | https://openalex.org/I96036126 |
| authorships[4].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Kumamoto University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Nanako Muraya |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[5].author.id | https://openalex.org/A5050086998 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-1584-249X |
| authorships[5].author.display_name | Yuki Narita |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I96036126 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I96036126 |
| authorships[5].affiliations[1].raw_affiliation_string | Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[5].institutions[0].id | https://openalex.org/I96036126 |
| authorships[5].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | Kumamoto University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Yuki Narita |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[6].author.id | https://openalex.org/A5111994746 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Keizo Sato |
| authorships[6].countries | JP |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I11023767 |
| authorships[6].affiliations[0].raw_affiliation_string | School of Pharmacy, Kyushu University of Health and Welfare |
| authorships[6].institutions[0].id | https://openalex.org/I11023767 |
| authorships[6].institutions[0].ror | https://ror.org/01banz567 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I11023767 |
| authorships[6].institutions[0].country_code | JP |
| authorships[6].institutions[0].display_name | Kyushu University of Health and Welfare |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Keizo Sato |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | School of Pharmacy, Kyushu University of Health and Welfare |
| authorships[7].author.id | https://openalex.org/A5042439651 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-2141-630X |
| authorships[7].author.display_name | Victor Tuan Giam Chuang |
| authorships[7].countries | AU |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I205640436 |
| authorships[7].affiliations[0].raw_affiliation_string | School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University |
| authorships[7].institutions[0].id | https://openalex.org/I205640436 |
| authorships[7].institutions[0].ror | https://ror.org/02n415q13 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I205640436 |
| authorships[7].institutions[0].country_code | AU |
| authorships[7].institutions[0].display_name | Curtin University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Victor Tuan Giam Chuang |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University |
| authorships[8].author.id | https://openalex.org/A5101981160 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-6543-4377 |
| authorships[8].author.display_name | Toru Maruyama |
| authorships[8].countries | JP |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I96036126 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I96036126 |
| authorships[8].affiliations[1].raw_affiliation_string | Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[8].institutions[0].id | https://openalex.org/I96036126 |
| authorships[8].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[8].institutions[0].country_code | JP |
| authorships[8].institutions[0].display_name | Kumamoto University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Toru Maruyama |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University |
| authorships[9].author.id | https://openalex.org/A5026222199 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-6244-3825 |
| authorships[9].author.display_name | Masaki Otagiri |
| authorships[9].countries | JP |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I181097317 |
| authorships[9].affiliations[0].raw_affiliation_string | Faculty of Pharmaceutical Sciences, Sojo University |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I96036126 |
| authorships[9].affiliations[1].raw_affiliation_string | Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University |
| authorships[9].institutions[0].id | https://openalex.org/I96036126 |
| authorships[9].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[9].institutions[0].country_code | JP |
| authorships[9].institutions[0].display_name | Kumamoto University |
| authorships[9].institutions[1].id | https://openalex.org/I181097317 |
| authorships[9].institutions[1].ror | https://ror.org/014fz7968 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I181097317 |
| authorships[9].institutions[1].country_code | JP |
| authorships[9].institutions[1].display_name | Sojo University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Masaki Otagiri |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Faculty of Pharmaceutical Sciences, Sojo University |
| authorships[10].author.id | https://openalex.org/A5000897475 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-3064-1963 |
| authorships[10].author.display_name | Sumío Hirata |
| authorships[10].countries | JP |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I96036126 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I96036126 |
| authorships[10].affiliations[1].raw_affiliation_string | Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University |
| authorships[10].institutions[0].id | https://openalex.org/I96036126 |
| authorships[10].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[10].institutions[0].country_code | JP |
| authorships[10].institutions[0].display_name | Kumamoto University |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Sumio Hirata |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.jstage.jst.go.jp/article/bpb/38/3/38_b14-00514/_pdf |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Direct Radical Scavenging Activity of Benzbromarone Provides Beneficial Antioxidant Properties for Hyperuricemia Treatment |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11139 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2727 |
| primary_topic.subfield.display_name | Nephrology |
| primary_topic.display_name | Gout, Hyperuricemia, Uric Acid |
| related_works | https://openalex.org/W2417649158, https://openalex.org/W3158645007, https://openalex.org/W2375522942, https://openalex.org/W3167171142, https://openalex.org/W3028648734, https://openalex.org/W2412642279, https://openalex.org/W3214382627, https://openalex.org/W2890068404, https://openalex.org/W2359673844, https://openalex.org/W2355917680 |
| cited_by_count | 38 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 6 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 2 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 2 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 5 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 6 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 4 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 2 |
| counts_by_year[8].year | 2017 |
| counts_by_year[8].cited_by_count | 2 |
| counts_by_year[9].year | 2016 |
| counts_by_year[9].cited_by_count | 3 |
| counts_by_year[10].year | 2015 |
| counts_by_year[10].cited_by_count | 3 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1248/bpb.b14-00514 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S165235614 |
| best_oa_location.source.issn | 0918-6158, 1347-5215 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 0918-6158 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Biological and Pharmaceutical Bulletin |
| best_oa_location.source.host_organization | https://openalex.org/P4310313382 |
| best_oa_location.source.host_organization_name | Pharmaceutical Society of Japan |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310313382 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.jstage.jst.go.jp/article/bpb/38/3/38_b14-00514/_pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Biological & Pharmaceutical Bulletin |
| best_oa_location.landing_page_url | https://doi.org/10.1248/bpb.b14-00514 |
| primary_location.id | doi:10.1248/bpb.b14-00514 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S165235614 |
| primary_location.source.issn | 0918-6158, 1347-5215 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 0918-6158 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Biological and Pharmaceutical Bulletin |
| primary_location.source.host_organization | https://openalex.org/P4310313382 |
| primary_location.source.host_organization_name | Pharmaceutical Society of Japan |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310313382 |
| primary_location.license | |
| primary_location.pdf_url | https://www.jstage.jst.go.jp/article/bpb/38/3/38_b14-00514/_pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Biological & Pharmaceutical Bulletin |
| primary_location.landing_page_url | https://doi.org/10.1248/bpb.b14-00514 |
| publication_date | 2015-01-01 |
| publication_year | 2015 |
| referenced_works | https://openalex.org/W2034499147, https://openalex.org/W2033546952, https://openalex.org/W2058725632, https://openalex.org/W1977424733, https://openalex.org/W2099273954, https://openalex.org/W2036811146, https://openalex.org/W2062431237, https://openalex.org/W2412013239, https://openalex.org/W2025372788, https://openalex.org/W1982235892, https://openalex.org/W2171576765, https://openalex.org/W1963700573, https://openalex.org/W2021959778, https://openalex.org/W2106362601, https://openalex.org/W2149786401, https://openalex.org/W2046572840, https://openalex.org/W1975976477, https://openalex.org/W2059571803, https://openalex.org/W2004301150, https://openalex.org/W2020764853, https://openalex.org/W2146822394, https://openalex.org/W2065473485, https://openalex.org/W2123162884, https://openalex.org/W2043172105, https://openalex.org/W1964198430, https://openalex.org/W2101391992, https://openalex.org/W1977110551, https://openalex.org/W2131859213, https://openalex.org/W195775769 |
| referenced_works_count | 29 |
| abstract_inverted_index.1 | 39, 80 |
| abstract_inverted_index.II | 60, 160 |
| abstract_inverted_index.In | 86, 132, 147 |
| abstract_inverted_index.an | 3, 183 |
| abstract_inverted_index.as | 182 |
| abstract_inverted_index.at | 196 |
| abstract_inverted_index.by | 110, 158 |
| abstract_inverted_index.in | 31, 42, 82, 92, 125, 164, 193, 200 |
| abstract_inverted_index.is | 40, 138 |
| abstract_inverted_index.of | 45, 96, 106, 123, 134 |
| abstract_inverted_index.or | 161 |
| abstract_inverted_index.to | 71, 141, 176 |
| abstract_inverted_index.we | 89 |
| abstract_inverted_index.act | 181 |
| abstract_inverted_index.and | 33, 61, 113, 179, 188 |
| abstract_inverted_index.can | 18 |
| abstract_inverted_index.has | 68 |
| abstract_inverted_index.may | 180 |
| abstract_inverted_index.the | 43, 54, 91, 102, 119, 143, 173 |
| abstract_inverted_index.via | 22, 76 |
| abstract_inverted_index.was | 108, 127, 156 |
| abstract_inverted_index.Uric | 0, 36 |
| abstract_inverted_index.acid | 1, 16, 37, 51, 74, 78, 163, 187 |
| abstract_inverted_index.been | 69 |
| abstract_inverted_index.from | 98 |
| abstract_inverted_index.that | 155, 170 |
| abstract_inverted_index.this | 46, 87 |
| abstract_inverted_index.thus | 57 |
| abstract_inverted_index.uric | 15, 50, 73, 77, 162, 186 |
| abstract_inverted_index.These | 167 |
| abstract_inverted_index.anion | 145 |
| abstract_inverted_index.assay | 112 |
| abstract_inverted_index.cells | 195 |
| abstract_inverted_index.light | 133 |
| abstract_inverted_index.renal | 83 |
| abstract_inverted_index.study | 88 |
| abstract_inverted_index.these | 135 |
| abstract_inverted_index.under | 11 |
| abstract_inverted_index.using | 129 |
| abstract_inverted_index.vitro | 93 |
| abstract_inverted_index.First, | 101 |
| abstract_inverted_index.blood. | 201 |
| abstract_inverted_index.cells. | 35, 85, 131, 166 |
| abstract_inverted_index.direct | 103 |
| abstract_inverted_index.effect | 6, 95 |
| abstract_inverted_index.exerts | 2 |
| abstract_inverted_index.itself | 17 |
| abstract_inverted_index.levels | 199 |
| abstract_inverted_index.oxygen | 152 |
| abstract_inverted_index.stress | 10, 21 |
| abstract_inverted_index.(NADPH) | 28 |
| abstract_inverted_index.Second, | 118 |
| abstract_inverted_index.ability | 174 |
| abstract_inverted_index.adenine | 25 |
| abstract_inverted_index.against | 7, 185 |
| abstract_inverted_index.induced | 157 |
| abstract_inverted_index.locally | 52 |
| abstract_inverted_index.oxidase | 29 |
| abstract_inverted_index.reduced | 23 |
| abstract_inverted_index.several | 99 |
| abstract_inverted_index.species | 153 |
| abstract_inverted_index.stress. | 48, 66 |
| abstract_inverted_index.suggest | 169 |
| abstract_inverted_index.system, | 56 |
| abstract_inverted_index.tubular | 84 |
| abstract_inverted_index.However, | 14 |
| abstract_inverted_index.activity | 122 |
| abstract_inverted_index.capacity | 105 |
| abstract_inverted_index.directly | 140, 175 |
| abstract_inverted_index.electron | 114 |
| abstract_inverted_index.external | 8 |
| abstract_inverted_index.findings | 168 |
| abstract_inverted_index.increase | 19 |
| abstract_inverted_index.involved | 41 |
| abstract_inverted_index.measured | 109 |
| abstract_inverted_index.radical. | 146 |
| abstract_inverted_index.radicals | 178 |
| abstract_inverted_index.reactive | 151 |
| abstract_inverted_index.reported | 70 |
| abstract_inverted_index.results, | 136 |
| abstract_inverted_index.scavenge | 142, 177 |
| abstract_inverted_index.stresses | 192 |
| abstract_inverted_index.suppress | 72 |
| abstract_inverted_index.vascular | 34 |
| abstract_inverted_index.activates | 53 |
| abstract_inverted_index.addition, | 148 |
| abstract_inverted_index.evaluated | 90, 128 |
| abstract_inverted_index.important | 4 |
| abstract_inverted_index.inhibited | 150 |
| abstract_inverted_index.oxidative | 9, 20, 47, 65, 191 |
| abstract_inverted_index.phosphate | 27 |
| abstract_inverted_index.possesses | 172 |
| abstract_inverted_index.producing | 58 |
| abstract_inverted_index.resonance | 116 |
| abstract_inverted_index.II-induced | 190 |
| abstract_inverted_index.achievable | 198 |
| abstract_inverted_index.activation | 30 |
| abstract_inverted_index.adipocytes | 32 |
| abstract_inverted_index.generation | 44 |
| abstract_inverted_index.increasing | 63 |
| abstract_inverted_index.inhibition | 81 |
| abstract_inverted_index.production | 154 |
| abstract_inverted_index.superoxide | 144 |
| abstract_inverted_index.angiotensin | 59, 159, 189 |
| abstract_inverted_index.antioxidant | 5, 94, 121, 184 |
| abstract_inverted_index.conditions. | 13 |
| abstract_inverted_index.endothelial | 130, 165, 194 |
| abstract_inverted_index.transporter | 38, 79 |
| abstract_inverted_index.Furthermore, | 49 |
| abstract_inverted_index.dinucleotide | 26 |
| abstract_inverted_index.hypothesized | 139 |
| abstract_inverted_index.nicotinamide | 24 |
| abstract_inverted_index.paramagnetic | 115 |
| abstract_inverted_index.reabsorption | 75 |
| abstract_inverted_index.subsequently | 62 |
| abstract_inverted_index.Benzbromarone | 67 |
| abstract_inverted_index.benzbromarone | 97, 107, 124, 137, 149, 171 |
| abstract_inverted_index.hyperuricemia | 126 |
| abstract_inverted_index.intracellular | 64, 120 |
| abstract_inverted_index.perspectives. | 100 |
| abstract_inverted_index.physiological | 12 |
| abstract_inverted_index.spectroscopy. | 117 |
| abstract_inverted_index.therapeutically | 197 |
| abstract_inverted_index.radical-trapping | 104 |
| abstract_inverted_index.chemiluminescence | 111 |
| abstract_inverted_index.renin-angiotensin | 55 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 11 |
| citation_normalized_percentile.value | 0.8526792 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |