Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme Article Swipe
Andrea B. Alber
,
Héctor Márquez
,
Liang Ma
,
George Kwong
,
Bibek R. Thapa
,
Carlos Villacorta-Martín
,
Jonathan Lindstrom-Vautrin
,
Pushpinder Bawa
,
Feiya Wang
,
Yongfeng Luo
,
Laertis Ikonomou
,
Wei Shi
,
Darrell N. Kotton
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-023-39099-9
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-023-39099-9
While the generation of many lineages from pluripotent stem cells has resulted in basic discoveries and clinical trials, the derivation of tissue-specific mesenchyme via directed differentiation has markedly lagged. The derivation of lung-specific mesenchyme is particularly important since this tissue plays crucial roles in lung development and disease. Here we generate a mouse induced pluripotent stem cell (iPSC) line carrying a lung-specific mesenchymal reporter/lineage tracer. We identify the pathways (RA and Shh) necessary to specify lung mesenchyme and find that mouse iPSC-derived lung mesenchyme (iLM) expresses key molecular and functional features of primary developing lung mesenchyme. iLM recombined with engineered lung epithelial progenitors self-organizes into 3D organoids with juxtaposed layers of epithelium and mesenchyme. Co-culture increases yield of lung epithelial progenitors and impacts epithelial and mesenchymal differentiation programs, suggesting functional crosstalk. Our iPSC-derived population thus provides an inexhaustible source of cells for studying lung development, modeling diseases, and developing therapeutics.
Related Topics
Concepts
Mesenchyme
Mesenchymal stem cell
Induced pluripotent stem cell
Biology
Progenitor cell
Cell biology
Stem cell
Cellular differentiation
Lung
Embryonic stem cell
Medicine
Genetics
Internal medicine
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41467-023-39099-9
- https://www.nature.com/articles/s41467-023-39099-9.pdf
- OA Status
- gold
- Cited By
- 18
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4380537255
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4380537255Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41467-023-39099-9Digital Object Identifier
- Title
-
Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchymeWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-13Full publication date if available
- Authors
-
Andrea B. Alber, Héctor Márquez, Liang Ma, George Kwong, Bibek R. Thapa, Carlos Villacorta-Martín, Jonathan Lindstrom-Vautrin, Pushpinder Bawa, Feiya Wang, Yongfeng Luo, Laertis Ikonomou, Wei Shi, Darrell N. KottonList of authors in order
- Landing page
-
https://doi.org/10.1038/s41467-023-39099-9Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41467-023-39099-9.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41467-023-39099-9.pdfDirect OA link when available
- Concepts
-
Mesenchyme, Mesenchymal stem cell, Induced pluripotent stem cell, Biology, Progenitor cell, Cell biology, Stem cell, Cellular differentiation, Lung, Embryonic stem cell, Medicine, Genetics, Internal medicine, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 10, 2023: 4, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4380537255 |
|---|---|
| doi | https://doi.org/10.1038/s41467-023-39099-9 |
| ids.doi | https://doi.org/10.1038/s41467-023-39099-9 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37311756 |
| ids.openalex | https://openalex.org/W4380537255 |
| fwci | 5.73537475 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D051379 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Mice |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D039904 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Pluripotent Stem Cells |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D002454 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Cell Differentiation |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D057026 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Induced Pluripotent Stem Cells |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D013909 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Thorax |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D008648 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Mesoderm |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D000818 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Animals |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D051379 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Mice |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D039904 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Pluripotent Stem Cells |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D002454 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Cell Differentiation |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D057026 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Induced Pluripotent Stem Cells |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D013909 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Thorax |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D008648 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Mesoderm |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000818 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Animals |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D051379 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Mice |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D039904 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Pluripotent Stem Cells |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D002454 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Cell Differentiation |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D057026 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Induced Pluripotent Stem Cells |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D013909 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Thorax |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D008648 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Mesoderm |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000818 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Animals |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D051379 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Mice |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D039904 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Pluripotent Stem Cells |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D002454 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Cell Differentiation |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D057026 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Induced Pluripotent Stem Cells |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D013909 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Thorax |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D008648 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Mesoderm |
| type | article |
| title | Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme |
| awards[0].id | https://openalex.org/G2828413098 |
| awards[0].funder_id | https://openalex.org/F4320337338 |
| awards[0].display_name | |
| awards[0].funder_award_id | R01HL095993 |
| awards[0].funder_display_name | National Heart, Lung, and Blood Institute |
| biblio.issue | 1 |
| biblio.volume | 14 |
| biblio.last_page | 3488 |
| biblio.first_page | 3488 |
| topics[0].id | https://openalex.org/T10549 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9973000288009644 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Neonatal Respiratory Health Research |
| topics[1].id | https://openalex.org/T12140 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9933000206947327 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Renal and related cancers |
| topics[2].id | https://openalex.org/T11392 |
| topics[2].field.id | https://openalex.org/fields/22 |
| topics[2].field.display_name | Engineering |
| topics[2].score | 0.9812999963760376 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2208 |
| topics[2].subfield.display_name | Electrical and Electronic Engineering |
| topics[2].display_name | Energy Harvesting in Wireless Networks |
| funders[0].id | https://openalex.org/F4320337338 |
| funders[0].ror | https://ror.org/012pb6c26 |
| funders[0].display_name | National Heart, Lung, and Blood Institute |
| is_xpac | False |
| apc_list.value | 3920 |
| apc_list.currency | GBP |
| apc_list.value_usd | 4808 |
| apc_paid.value | 3920 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 4808 |
| concepts[0].id | https://openalex.org/C2776340970 |
| concepts[0].level | 3 |
| concepts[0].score | 0.9741103649139404 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q32838 |
| concepts[0].display_name | Mesenchyme |
| concepts[1].id | https://openalex.org/C198826908 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7370296716690063 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1922379 |
| concepts[1].display_name | Mesenchymal stem cell |
| concepts[2].id | https://openalex.org/C107459253 |
| concepts[2].level | 4 |
| concepts[2].score | 0.707438051700592 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q674925 |
| concepts[2].display_name | Induced pluripotent stem cell |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.6749265193939209 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C201750760 |
| concepts[4].level | 3 |
| concepts[4].score | 0.6316626071929932 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1896218 |
| concepts[4].display_name | Progenitor cell |
| concepts[5].id | https://openalex.org/C95444343 |
| concepts[5].level | 1 |
| concepts[5].score | 0.6277936697006226 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[5].display_name | Cell biology |
| concepts[6].id | https://openalex.org/C28328180 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5060555338859558 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q48196 |
| concepts[6].display_name | Stem cell |
| concepts[7].id | https://openalex.org/C148738053 |
| concepts[7].level | 3 |
| concepts[7].score | 0.47811856865882874 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q210861 |
| concepts[7].display_name | Cellular differentiation |
| concepts[8].id | https://openalex.org/C2777714996 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4419747591018677 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7886 |
| concepts[8].display_name | Lung |
| concepts[9].id | https://openalex.org/C145103041 |
| concepts[9].level | 3 |
| concepts[9].score | 0.3280983567237854 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1151519 |
| concepts[9].display_name | Embryonic stem cell |
| concepts[10].id | https://openalex.org/C71924100 |
| concepts[10].level | 0 |
| concepts[10].score | 0.11273366212844849 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[10].display_name | Medicine |
| concepts[11].id | https://openalex.org/C54355233 |
| concepts[11].level | 1 |
| concepts[11].score | 0.10314586758613586 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[11].display_name | Genetics |
| concepts[12].id | https://openalex.org/C126322002 |
| concepts[12].level | 1 |
| concepts[12].score | 0.09272167086601257 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[12].display_name | Internal medicine |
| concepts[13].id | https://openalex.org/C104317684 |
| concepts[13].level | 2 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[13].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/mesenchyme |
| keywords[0].score | 0.9741103649139404 |
| keywords[0].display_name | Mesenchyme |
| keywords[1].id | https://openalex.org/keywords/mesenchymal-stem-cell |
| keywords[1].score | 0.7370296716690063 |
| keywords[1].display_name | Mesenchymal stem cell |
| keywords[2].id | https://openalex.org/keywords/induced-pluripotent-stem-cell |
| keywords[2].score | 0.707438051700592 |
| keywords[2].display_name | Induced pluripotent stem cell |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.6749265193939209 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/progenitor-cell |
| keywords[4].score | 0.6316626071929932 |
| keywords[4].display_name | Progenitor cell |
| keywords[5].id | https://openalex.org/keywords/cell-biology |
| keywords[5].score | 0.6277936697006226 |
| keywords[5].display_name | Cell biology |
| keywords[6].id | https://openalex.org/keywords/stem-cell |
| keywords[6].score | 0.5060555338859558 |
| keywords[6].display_name | Stem cell |
| keywords[7].id | https://openalex.org/keywords/cellular-differentiation |
| keywords[7].score | 0.47811856865882874 |
| keywords[7].display_name | Cellular differentiation |
| keywords[8].id | https://openalex.org/keywords/lung |
| keywords[8].score | 0.4419747591018677 |
| keywords[8].display_name | Lung |
| keywords[9].id | https://openalex.org/keywords/embryonic-stem-cell |
| keywords[9].score | 0.3280983567237854 |
| keywords[9].display_name | Embryonic stem cell |
| keywords[10].id | https://openalex.org/keywords/medicine |
| keywords[10].score | 0.11273366212844849 |
| keywords[10].display_name | Medicine |
| keywords[11].id | https://openalex.org/keywords/genetics |
| keywords[11].score | 0.10314586758613586 |
| keywords[11].display_name | Genetics |
| keywords[12].id | https://openalex.org/keywords/internal-medicine |
| keywords[12].score | 0.09272167086601257 |
| keywords[12].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.1038/s41467-023-39099-9 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S64187185 |
| locations[0].source.issn | 2041-1723 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2041-1723 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Nature Communications |
| locations[0].source.host_organization | https://openalex.org/P4310319908 |
| locations[0].source.host_organization_name | Nature Portfolio |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319908, https://openalex.org/P4310319965 |
| locations[0].source.host_organization_lineage_names | Nature Portfolio, Springer Nature |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.nature.com/articles/s41467-023-39099-9.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Nature Communications |
| locations[0].landing_page_url | https://doi.org/10.1038/s41467-023-39099-9 |
| locations[1].id | pmid:37311756 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Nature communications |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37311756 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10264380 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10264380/pdf/41467_2023_Article_39099.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Nat Commun |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10264380 |
| locations[3].id | pmh:oai:doaj.org/article:679e27bdb9be4dbfbe24f069fd027cd6 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023) |
| locations[3].landing_page_url | https://doaj.org/article/679e27bdb9be4dbfbe24f069fd027cd6 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5017573852 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-6183-7208 |
| authorships[0].author.display_name | Andrea B. Alber |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I111088046, https://openalex.org/I1286490081 |
| authorships[0].affiliations[0].raw_affiliation_string | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[0].institutions[0].id | https://openalex.org/I1286490081 |
| authorships[0].institutions[0].ror | https://ror.org/010b9wj87 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I1286490081 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Boston Medical Center |
| authorships[0].institutions[1].id | https://openalex.org/I111088046 |
| authorships[0].institutions[1].ror | https://ror.org/05qwgg493 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I111088046 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | Boston University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Andrea B. Alber |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[1].author.id | https://openalex.org/A5013029692 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Héctor Márquez |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I111088046, https://openalex.org/I1286490081 |
| authorships[1].affiliations[0].raw_affiliation_string | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[1].institutions[0].id | https://openalex.org/I1286490081 |
| authorships[1].institutions[0].ror | https://ror.org/010b9wj87 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1286490081 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Boston Medical Center |
| authorships[1].institutions[1].id | https://openalex.org/I111088046 |
| authorships[1].institutions[1].ror | https://ror.org/05qwgg493 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I111088046 |
| authorships[1].institutions[1].country_code | US |
| authorships[1].institutions[1].display_name | Boston University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Hector A. Marquez |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[2].author.id | https://openalex.org/A5082561087 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-2938-0716 |
| authorships[2].author.display_name | Liang Ma |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I111088046, https://openalex.org/I1286490081 |
| authorships[2].affiliations[0].raw_affiliation_string | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[2].institutions[0].id | https://openalex.org/I1286490081 |
| authorships[2].institutions[0].ror | https://ror.org/010b9wj87 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1286490081 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Boston Medical Center |
| authorships[2].institutions[1].id | https://openalex.org/I111088046 |
| authorships[2].institutions[1].ror | https://ror.org/05qwgg493 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I111088046 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | Boston University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Liang Ma |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[3].author.id | https://openalex.org/A5052867462 |
| authorships[3].author.orcid | https://orcid.org/0009-0002-8943-2979 |
| authorships[3].author.display_name | George Kwong |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I111088046, https://openalex.org/I1286490081 |
| authorships[3].affiliations[0].raw_affiliation_string | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[3].institutions[0].id | https://openalex.org/I1286490081 |
| authorships[3].institutions[0].ror | https://ror.org/010b9wj87 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1286490081 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Boston Medical Center |
| authorships[3].institutions[1].id | https://openalex.org/I111088046 |
| authorships[3].institutions[1].ror | https://ror.org/05qwgg493 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I111088046 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | Boston University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | George Kwong |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[4].author.id | https://openalex.org/A5020062830 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-5254-0808 |
| authorships[4].author.display_name | Bibek R. Thapa |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I111088046, https://openalex.org/I1286490081 |
| authorships[4].affiliations[0].raw_affiliation_string | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[4].institutions[0].id | https://openalex.org/I1286490081 |
| authorships[4].institutions[0].ror | https://ror.org/010b9wj87 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1286490081 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Boston Medical Center |
| authorships[4].institutions[1].id | https://openalex.org/I111088046 |
| authorships[4].institutions[1].ror | https://ror.org/05qwgg493 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I111088046 |
| authorships[4].institutions[1].country_code | US |
| authorships[4].institutions[1].display_name | Boston University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Bibek R. Thapa |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[5].author.id | https://openalex.org/A5052352078 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-1350-465X |
| authorships[5].author.display_name | Carlos Villacorta-Martín |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I111088046, https://openalex.org/I1286490081 |
| authorships[5].affiliations[0].raw_affiliation_string | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[5].institutions[0].id | https://openalex.org/I1286490081 |
| authorships[5].institutions[0].ror | https://ror.org/010b9wj87 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1286490081 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Boston Medical Center |
| authorships[5].institutions[1].id | https://openalex.org/I111088046 |
| authorships[5].institutions[1].ror | https://ror.org/05qwgg493 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I111088046 |
| authorships[5].institutions[1].country_code | US |
| authorships[5].institutions[1].display_name | Boston University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Carlos Villacorta-Martin |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[6].author.id | https://openalex.org/A5007121256 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-8132-424X |
| authorships[6].author.display_name | Jonathan Lindstrom-Vautrin |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I111088046, https://openalex.org/I1286490081 |
| authorships[6].affiliations[0].raw_affiliation_string | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[6].institutions[0].id | https://openalex.org/I1286490081 |
| authorships[6].institutions[0].ror | https://ror.org/010b9wj87 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I1286490081 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Boston Medical Center |
| authorships[6].institutions[1].id | https://openalex.org/I111088046 |
| authorships[6].institutions[1].ror | https://ror.org/05qwgg493 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I111088046 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | Boston University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Jonathan Lindstrom-Vautrin |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[7].author.id | https://openalex.org/A5022360517 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8370-3638 |
| authorships[7].author.display_name | Pushpinder Bawa |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I111088046, https://openalex.org/I1286490081 |
| authorships[7].affiliations[0].raw_affiliation_string | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[7].institutions[0].id | https://openalex.org/I1286490081 |
| authorships[7].institutions[0].ror | https://ror.org/010b9wj87 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1286490081 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Boston Medical Center |
| authorships[7].institutions[1].id | https://openalex.org/I111088046 |
| authorships[7].institutions[1].ror | https://ror.org/05qwgg493 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I111088046 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | Boston University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Pushpinder Bawa |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[8].author.id | https://openalex.org/A5053137432 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-7507-6275 |
| authorships[8].author.display_name | Feiya Wang |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I111088046, https://openalex.org/I1286490081 |
| authorships[8].affiliations[0].raw_affiliation_string | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[8].institutions[0].id | https://openalex.org/I1286490081 |
| authorships[8].institutions[0].ror | https://ror.org/010b9wj87 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I1286490081 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Boston Medical Center |
| authorships[8].institutions[1].id | https://openalex.org/I111088046 |
| authorships[8].institutions[1].ror | https://ror.org/05qwgg493 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I111088046 |
| authorships[8].institutions[1].country_code | US |
| authorships[8].institutions[1].display_name | Boston University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Feiya Wang |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA |
| authorships[9].author.id | https://openalex.org/A5114357198 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-8765-0273 |
| authorships[9].author.display_name | Yongfeng Luo |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I1174212, https://openalex.org/I1336910626 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, USA |
| authorships[9].institutions[0].id | https://openalex.org/I1336910626 |
| authorships[9].institutions[0].ror | https://ror.org/00412ts95 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I1336910626 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Children's Hospital of Los Angeles |
| authorships[9].institutions[1].id | https://openalex.org/I1174212 |
| authorships[9].institutions[1].ror | https://ror.org/03taz7m60 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I1174212 |
| authorships[9].institutions[1].country_code | US |
| authorships[9].institutions[1].display_name | University of Southern California |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Yongfeng Luo |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, USA |
| authorships[10].author.id | https://openalex.org/A5030293525 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-0993-6713 |
| authorships[10].author.display_name | Laertis Ikonomou |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I63190737 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, NY, 14260, USA |
| authorships[10].institutions[0].id | https://openalex.org/I63190737 |
| authorships[10].institutions[0].ror | https://ror.org/01y64my43 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I63190737 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | University at Buffalo, State University of New York |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Laertis Ikonomou |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, NY, 14260, USA |
| authorships[11].author.id | https://openalex.org/A5079936447 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-6499-2473 |
| authorships[11].author.display_name | Wei Shi |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I92156820 |
| authorships[11].affiliations[0].raw_affiliation_string | Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA |
| authorships[11].institutions[0].id | https://openalex.org/I92156820 |
| authorships[11].institutions[0].ror | https://ror.org/02p72h367 |
| authorships[11].institutions[0].type | healthcare |
| authorships[11].institutions[0].lineage | https://openalex.org/I92156820 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | University of Cincinnati Medical Center |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Wei Shi |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA |
| authorships[12].author.id | https://openalex.org/A5046812442 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-9604-8476 |
| authorships[12].author.display_name | Darrell N. Kotton |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[12].affiliations[0].raw_affiliation_string | The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA |
| authorships[12].institutions[0].id | https://openalex.org/I111088046 |
| authorships[12].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Boston University |
| authorships[12].author_position | last |
| authorships[12].raw_author_name | Darrell N. Kotton |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.nature.com/articles/s41467-023-39099-9.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T10549 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9973000288009644 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Neonatal Respiratory Health Research |
| related_works | https://openalex.org/W2066692229, https://openalex.org/W1983177105, https://openalex.org/W2169713767, https://openalex.org/W1987492131, https://openalex.org/W1980760536, https://openalex.org/W1489148714, https://openalex.org/W2470459242, https://openalex.org/W2768952912, https://openalex.org/W3110176598, https://openalex.org/W2053561999 |
| cited_by_count | 18 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 10 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 4 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1038/s41467-023-39099-9 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S64187185 |
| best_oa_location.source.issn | 2041-1723 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2041-1723 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Nature Communications |
| best_oa_location.source.host_organization | https://openalex.org/P4310319908 |
| best_oa_location.source.host_organization_name | Nature Portfolio |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319908, https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_lineage_names | Nature Portfolio, Springer Nature |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.nature.com/articles/s41467-023-39099-9.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Nature Communications |
| best_oa_location.landing_page_url | https://doi.org/10.1038/s41467-023-39099-9 |
| primary_location.id | doi:10.1038/s41467-023-39099-9 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S64187185 |
| primary_location.source.issn | 2041-1723 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2041-1723 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Nature Communications |
| primary_location.source.host_organization | https://openalex.org/P4310319908 |
| primary_location.source.host_organization_name | Nature Portfolio |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319908, https://openalex.org/P4310319965 |
| primary_location.source.host_organization_lineage_names | Nature Portfolio, Springer Nature |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.nature.com/articles/s41467-023-39099-9.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Nature Communications |
| primary_location.landing_page_url | https://doi.org/10.1038/s41467-023-39099-9 |
| publication_date | 2023-06-13 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2070864748, https://openalex.org/W3080735488, https://openalex.org/W1827970981, https://openalex.org/W1963272169, https://openalex.org/W2012896764, https://openalex.org/W2079667206, https://openalex.org/W2070643063, https://openalex.org/W3080202614, https://openalex.org/W1607596367, https://openalex.org/W2036287744, https://openalex.org/W2420197495, https://openalex.org/W2102283220, https://openalex.org/W1974681197, https://openalex.org/W1979816073, https://openalex.org/W2157891574, https://openalex.org/W2156862506, https://openalex.org/W2132020845, https://openalex.org/W2003211588, https://openalex.org/W2611660641, https://openalex.org/W3093620357, https://openalex.org/W2127479534, https://openalex.org/W2756634427, https://openalex.org/W2797630570, https://openalex.org/W2598899113, https://openalex.org/W2421964473, https://openalex.org/W2759156549, https://openalex.org/W2763126295, https://openalex.org/W4292121815, https://openalex.org/W2609587333, https://openalex.org/W4206283957, https://openalex.org/W1968761061, https://openalex.org/W2053351885, https://openalex.org/W2050166215, https://openalex.org/W2035850696, https://openalex.org/W2969164995, https://openalex.org/W1982748372, https://openalex.org/W3003674344, https://openalex.org/W2110042849, https://openalex.org/W1978596841, https://openalex.org/W2038111952, https://openalex.org/W1979927933, https://openalex.org/W2050308681, https://openalex.org/W2143951787, https://openalex.org/W2042068972, https://openalex.org/W3135360764, https://openalex.org/W2751524454, https://openalex.org/W2874034467, https://openalex.org/W3211050216, https://openalex.org/W3016965350, https://openalex.org/W4296356807, https://openalex.org/W3214967637, https://openalex.org/W2166323322, https://openalex.org/W2107277218, https://openalex.org/W2997280954, https://openalex.org/W2786672974, https://openalex.org/W2952650776, https://openalex.org/W2131681506, https://openalex.org/W2332292689, https://openalex.org/W2190545194, https://openalex.org/W1964184380, https://openalex.org/W3099768174, https://openalex.org/W4220702068, https://openalex.org/W4225642237 |
| referenced_works_count | 63 |
| abstract_inverted_index.a | 52, 61 |
| abstract_inverted_index.3D | 106 |
| abstract_inverted_index.We | 66 |
| abstract_inverted_index.an | 137 |
| abstract_inverted_index.in | 13, 44 |
| abstract_inverted_index.is | 35 |
| abstract_inverted_index.of | 4, 21, 32, 92, 111, 118, 140 |
| abstract_inverted_index.to | 74 |
| abstract_inverted_index.we | 50 |
| abstract_inverted_index.(RA | 70 |
| abstract_inverted_index.Our | 132 |
| abstract_inverted_index.The | 30 |
| abstract_inverted_index.and | 16, 47, 71, 78, 89, 113, 122, 125, 148 |
| abstract_inverted_index.for | 142 |
| abstract_inverted_index.has | 11, 27 |
| abstract_inverted_index.iLM | 97 |
| abstract_inverted_index.key | 87 |
| abstract_inverted_index.the | 2, 19, 68 |
| abstract_inverted_index.via | 24 |
| abstract_inverted_index.Here | 49 |
| abstract_inverted_index.Shh) | 72 |
| abstract_inverted_index.cell | 57 |
| abstract_inverted_index.find | 79 |
| abstract_inverted_index.from | 7 |
| abstract_inverted_index.into | 105 |
| abstract_inverted_index.line | 59 |
| abstract_inverted_index.lung | 45, 76, 83, 95, 101, 119, 144 |
| abstract_inverted_index.many | 5 |
| abstract_inverted_index.stem | 9, 56 |
| abstract_inverted_index.that | 80 |
| abstract_inverted_index.this | 39 |
| abstract_inverted_index.thus | 135 |
| abstract_inverted_index.with | 99, 108 |
| abstract_inverted_index.(iLM) | 85 |
| abstract_inverted_index.While | 1 |
| abstract_inverted_index.basic | 14 |
| abstract_inverted_index.cells | 10, 141 |
| abstract_inverted_index.mouse | 53, 81 |
| abstract_inverted_index.plays | 41 |
| abstract_inverted_index.roles | 43 |
| abstract_inverted_index.since | 38 |
| abstract_inverted_index.yield | 117 |
| abstract_inverted_index.(iPSC) | 58 |
| abstract_inverted_index.layers | 110 |
| abstract_inverted_index.source | 139 |
| abstract_inverted_index.tissue | 40 |
| abstract_inverted_index.crucial | 42 |
| abstract_inverted_index.impacts | 123 |
| abstract_inverted_index.induced | 54 |
| abstract_inverted_index.lagged. | 29 |
| abstract_inverted_index.primary | 93 |
| abstract_inverted_index.specify | 75 |
| abstract_inverted_index.tracer. | 65 |
| abstract_inverted_index.trials, | 18 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.carrying | 60 |
| abstract_inverted_index.clinical | 17 |
| abstract_inverted_index.directed | 25 |
| abstract_inverted_index.disease. | 48 |
| abstract_inverted_index.features | 91 |
| abstract_inverted_index.generate | 51 |
| abstract_inverted_index.identify | 67 |
| abstract_inverted_index.lineages | 6 |
| abstract_inverted_index.markedly | 28 |
| abstract_inverted_index.modeling | 146 |
| abstract_inverted_index.pathways | 69 |
| abstract_inverted_index.provides | 136 |
| abstract_inverted_index.resulted | 12 |
| abstract_inverted_index.studying | 143 |
| abstract_inverted_index.diseases, | 147 |
| abstract_inverted_index.expresses | 86 |
| abstract_inverted_index.important | 37 |
| abstract_inverted_index.increases | 116 |
| abstract_inverted_index.molecular | 88 |
| abstract_inverted_index.necessary | 73 |
| abstract_inverted_index.organoids | 107 |
| abstract_inverted_index.programs, | 128 |
| abstract_inverted_index.Co-culture | 115 |
| abstract_inverted_index.crosstalk. | 131 |
| abstract_inverted_index.derivation | 20, 31 |
| abstract_inverted_index.developing | 94, 149 |
| abstract_inverted_index.engineered | 100 |
| abstract_inverted_index.epithelial | 102, 120, 124 |
| abstract_inverted_index.epithelium | 112 |
| abstract_inverted_index.functional | 90, 130 |
| abstract_inverted_index.generation | 3 |
| abstract_inverted_index.juxtaposed | 109 |
| abstract_inverted_index.mesenchyme | 23, 34, 77, 84 |
| abstract_inverted_index.population | 134 |
| abstract_inverted_index.recombined | 98 |
| abstract_inverted_index.suggesting | 129 |
| abstract_inverted_index.development | 46 |
| abstract_inverted_index.discoveries | 15 |
| abstract_inverted_index.mesenchymal | 63, 126 |
| abstract_inverted_index.mesenchyme. | 96, 114 |
| abstract_inverted_index.pluripotent | 8, 55 |
| abstract_inverted_index.progenitors | 103, 121 |
| abstract_inverted_index.development, | 145 |
| abstract_inverted_index.iPSC-derived | 82, 133 |
| abstract_inverted_index.particularly | 36 |
| abstract_inverted_index.inexhaustible | 138 |
| abstract_inverted_index.lung-specific | 33, 62 |
| abstract_inverted_index.therapeutics. | 150 |
| abstract_inverted_index.self-organizes | 104 |
| abstract_inverted_index.differentiation | 26, 127 |
| abstract_inverted_index.tissue-specific | 22 |
| abstract_inverted_index.reporter/lineage | 64 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| citation_normalized_percentile.value | 0.9585779 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |