Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC Article Swipe

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Linhong He , Da Li , Chufeng Zhang , Peng Bai , Lijuan Chen ·

YOU? · · 2017 · Open Access · · DOI: https://doi.org/10.1016/j.bmcl.2017.07.009

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Epidermal Growth Factor Receptor

Concepts

Ibrutinib Chemistry T790M Pharmacology Bruton's tyrosine kinase Bioavailability IC50 Kinase Lung cancer Erlotinib Stereochemistry Biochemistry Epidermal growth factor receptor Tyrosine kinase In vitro Receptor Leukemia Gefitinib Internal medicine Chronic lymphocytic leukemia Medicine

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.bmcl.2017.07.009
OA Status: green
Cited By: 14
References: 28
Related Works: 10
OpenAlex ID: https://openalex.org/W2734255887

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DOI: https://doi.org/10.1016/j.bmcl.2017.07.009

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Title: Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC

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Type: article

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Language: en

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Publication year: 2017

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Publication date: 2017-07-04

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Authors: Linhong He, Da Li, Chufeng Zhang, Peng Bai, Lijuan Chen

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Landing page: https://doi.org/10.1016/j.bmcl.2017.07.009

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OA URL: https://doi.org/10.7270/q2ww7m50

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Concepts: Ibrutinib, Chemistry, T790M, Pharmacology, Bruton's tyrosine kinase, Bioavailability, IC50, Kinase, Lung cancer, Erlotinib, Stereochemistry, Biochemistry, Epidermal growth factor receptor, Tyrosine kinase, In vitro, Receptor, Leukemia, Gefitinib, Internal medicine, Chronic lymphocytic leukemia, Medicine

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Cited by: 14

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Citations by year (recent): 2025: 2, 2024: 1, 2023: 2, 2022: 2, 2021: 5

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References (count): 28

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title	Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC
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