Discovery of the gut microbial signature driving the efficacy of prebiotic intervention on liver steatosis Article Swipe
Julie Rodriguez
,
Nicolas Lanthier
,
Sophie Hiel
,
Audrey M. Neyrinck
,
Tiphaine Le Roy
,
Sarah A. Pötgens
,
Quentin Leyrolle
,
Barbara D. Pachikian
,
MA Gianfrancesco
,
Patrice D. Cani
,
Nicolas Paquot
,
Miriam Cnop
,
Jean‐Paul Thissen
,
Laure B. Bindels
,
Nathalie M. Delzenne
·
YOU?
·
· 2020
· Open Access
·
YOU?
·
· 2020
· Open Access
·
Introduction : Dietary supplementation with inulin as a prebiotic has been shown to lessen obesity and related metabolic disorders in some individuals. Previous work highlighted the interest of prebiotic supplementation in the management of hepatic steatosis in preclinical models. However, the efficiency of such nutritional interventions in humans remains unclear. Aim : Using a cohort of obese individuals treated with inulin versus placebo (FOOD4GUT cohort), and a model of mice transferred with the fecal microbiota from obese patients, we have addressed the following question : do the characteristics of the gut microbiota in obese individuals influence the effect of inulin on hepatic disorders? Methods : The gut microbiota of four-week old mice was depleted using antibiotics. Four groups of mice were then colonized with stools from four human obese patients (hum-ob) selected for different gut microbiota composition, presence of hepatic steatosis and response to inulin in an interventional study. Conventional and hum-ob mice were then fed with a high-fat diet (HFD) during four additional weeks, supplemented or not with native inulin (Cosucra) (6-9 mice per group). Results : We demonstrated a different response to inulin supplementation in the four groups of mice inoculated with different fecal material. Inulin significantly reduced the hepatic lipid content in mice inoculated with the faeces of two out of the four donors. The decrease in hepatic lipid accumulation in “responder” mice was associated with a reduced activation of nuclear expression of markers involved in lipids synthesis (SREBP1 and SREBP2 proteins).. Despite an increased cecal content – signing gut fermentation - observed in all humanized mice, the regulation of the gut microbiota by inulin also differed between donors. Interestingly, some bacterial genera were positively correlated with liver lipids and triglycerides (Barnesiella, Bilophila, Butyricimonas…) whereas some others ones are negatively associated with these parameters (such as Akkermansia or Clostridium XIVa). The different regulation of these bacteria by inulin may explain the observed difference on hepatic lipid metabolism in responder and non-responders in humans. Conclusions : Our work using a model of gut microbiota transfer from patients into mice highlighted the differential response of humanized mice to dietary supplementation with inulin. We propose that the gut microbiota is an important component to take into account for personalized nutrition related to prebiotic dietary fibers in the future and the management of metabolic disorders including hepatic steatosis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- http://hdl.handle.net/2078.1/232902
- OA Status
- green
- Cited By
- 1
- Related Works
- 20
- OpenAlex ID
- https://openalex.org/W3092675007
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3092675007Canonical identifier for this work in OpenAlex
- Title
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Discovery of the gut microbial signature driving the efficacy of prebiotic intervention on liver steatosisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-01Full publication date if available
- Authors
-
Julie Rodriguez, Nicolas Lanthier, Sophie Hiel, Audrey M. Neyrinck, Tiphaine Le Roy, Sarah A. Pötgens, Quentin Leyrolle, Barbara D. Pachikian, MA Gianfrancesco, Patrice D. Cani, Nicolas Paquot, Miriam Cnop, Jean‐Paul Thissen, Laure B. Bindels, Nathalie M. DelzenneList of authors in order
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https://hdl.handle.net/2078.1/232902Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://hdl.handle.net/2078.1/232902Direct OA link when available
- Concepts
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Prebiotic, Steatosis, Signature (topology), Liver steatosis, Intervention (counseling), Medicine, Food science, Biology, Fatty liver, Internal medicine, Mathematics, Psychiatry, Disease, GeometryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2021: 1Per-year citation counts (last 5 years)
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20Other works algorithmically related by OpenAlex
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