Discovery of Zoanthamine Alkaloids from Zoanthus vietnamensis with Antioxidant and Neuroprotective Activities Article Swipe
Shu‐Rong Chen
,
Yang-Chen Chang
,
Yi‐Ping Phoebe Chen
,
Yih‐Fung Chen
,
Yu‐Chi Lin
,
Cheng‐chau Chiu
,
Yuan‐Bin Cheng
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.joc.5c00280
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.joc.5c00280
Two novel alkaloids, zoanides A and B (1 and 2), 12 new zoanthamine-type alkaloids (3-14), together with two known compounds (15 and 16) were obtained from the zoantharian Zoanthus vietnamensis. Their structures and absolute configurations were established by extensive spectroscopic data, DP4+ probability calculation, and X-ray crystallographic analyses. Structurally, compound 1 represents an unusual functionalized skeleton caused by oxidative cleavage; compound 2 possesses an unprecedented 6/6/5/6/7-fused pentacyclic carbon skeleton. Additionally, the plausible biosynthetic pathways of 1 and 2 were proposed. All isolates were evaluated in vitro for neuroprotection. Among them, compounds 2, 3, 8, 9, and 15 exhibited neuroprotection against paclitaxel-induced neurite damage without interfering with the anticancer effects of paclitaxel. Moreover, compounds 2 and 9 demonstrated moderate protective effects against oxaliplatin-induced oxidative stress overload without interfering with the anticancer effects of oxaliplatin.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.joc.5c00280
- OA Status
- hybrid
- Cited By
- 1
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409087945
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409087945Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acs.joc.5c00280Digital Object Identifier
- Title
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Discovery of Zoanthamine Alkaloids from Zoanthus vietnamensis with Antioxidant and Neuroprotective ActivitiesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-02Full publication date if available
- Authors
-
Shu‐Rong Chen, Yang-Chen Chang, Yi‐Ping Phoebe Chen, Yih‐Fung Chen, Yu‐Chi Lin, Cheng‐chau Chiu, Yuan‐Bin ChengList of authors in order
- Landing page
-
https://doi.org/10.1021/acs.joc.5c00280Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1021/acs.joc.5c00280Direct OA link when available
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Neuroprotection, Antioxidant, Traditional medicine, Chemistry, Biology, Pharmacology, Medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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33Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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