Disease-specific Mortality of Differentiated Thyroid Cancer With Distant Metastases Article Swipe
Ali Howaidi
,
Anwar Ali Alswailem
,
Abdulrhman Hakami
,
Afnan Hadadi
,
Deema Alturki
,
Fayha Abothenain
,
Lulu Alobaid
,
Najla Saleh Ewain
,
Avaniyapuram Kannan Murugan
,
Ali S. Alzahrani
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1210/jendso/bvaf034
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1210/jendso/bvaf034
Overview Distant metastases (DM) are the major cause of death in patients with differentiated thyroid cancer (DTC). This study aimed to investigate the predictors of DM-associated mortality. Patients and Methods We identified 154 thyroid cancer (TC) patients with DM from our institution's tumor registry. We excluded anaplastic (n = 21) and medullary TC (n = 32) and patients with inadequate data (n = 15). The remaining 86 patients with DTC were studied. These include 57 females (66.3%) and 29 males (33.7%) with a median age of 53.5 years [interquartile range (IQR) 45-65]. All patients underwent thyroidectomy; 58 (67.4%) had neck dissection, and 81 (94.2%) received radioactive iodine (I-131) ablation/therapy. Results Lung metastases were the most common, occurring in 91.9%; skeletal metastases occurred in 58.1%, brain metastases in 9.3%, and multiple-organ DM in 58%. The management of DM included surgery, 1 or more doses of I-131, external beam radiotherapy, and multikinase inhibitors. Over a median follow-up of 84 months (IQR 35.5-118) for the whole cohort, 47 patients succumbed to their disease (disease-specific mortality 54.7%). Factors associated with mortality were increasing age (P = .001) and bone metastases (P < .0001). These factors remained significant in multivariate analyses [for age, P = .009, hazard ratio (HR) 1.030, 95% confidence interval (CI) 1.007-1.053] and for bone metastases (P = .017, HR 2.58, 95% CI 1.19-5.6). Conclusion DM from DTC are associated with ∼ 55% mortality at a median survival of 47 months. Increasing age and skeletal metastases are predictors of an increased risk of mortality.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1210/jendso/bvaf034
- https://academic.oup.com/jes/advance-article-pdf/doi/10.1210/jendso/bvaf034/62113157/bvaf034.pdf
- OA Status
- gold
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4407871581
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407871581Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1210/jendso/bvaf034Digital Object Identifier
- Title
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Disease-specific Mortality of Differentiated Thyroid Cancer With Distant MetastasesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-24Full publication date if available
- Authors
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Ali Howaidi, Anwar Ali Alswailem, Abdulrhman Hakami, Afnan Hadadi, Deema Alturki, Fayha Abothenain, Lulu Alobaid, Najla Saleh Ewain, Avaniyapuram Kannan Murugan, Ali S. AlzahraniList of authors in order
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https://doi.org/10.1210/jendso/bvaf034Publisher landing page
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https://academic.oup.com/jes/advance-article-pdf/doi/10.1210/jendso/bvaf034/62113157/bvaf034.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/jes/advance-article-pdf/doi/10.1210/jendso/bvaf034/62113157/bvaf034.pdfDirect OA link when available
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Disease, Thyroid cancer, Medicine, Oncology, Cancer, Internal medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
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10Other works algorithmically related by OpenAlex
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