Disruption of HaVipR1 confers Vip3Aa resistance in the moth crop pest Helicoverpa armigera Article Swipe
Andreas Bachler
,
Amanda Padovan
,
Craig Anderson
,
Yiyun Wei
,
Yidong Wu
,
Stephen L. Pearce
,
Sharon Downes
,
Bill James
,
Ashley E. Tessnow
,
Gregory A. Sword
,
Michelle Williams
,
Wee Tek Tay
,
Karl Gordon
,
Tom Walsh
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pbio.3003165
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pbio.3003165
The global reliance on Bacillus thuringiensis (Bt) proteins for controlling lepidopteran pests in cotton, corn, and soybean crops underscores the critical need to understand resistance mechanisms. Vip3Aa, one of the most widely deployed and currently effective Bt proteins in genetically modified crops, plays a pivotal role in pest management. This study investigates the molecular basis of Vip3Aa resistance in Australian Helicoverpa armigera through genetic crosses, and integrated genomic and transcriptomic analyses. We identified a previously uncharacterized gene, LOC110373801 (designated HaVipR1 ), as potentially important in Vip3Aa resistance in two field-derived resistant lines. Functional validation using CRISPR/Cas9 knockout in susceptible lines confirmed the gene’s role in conferring high-level resistance to Vip3Aa. Despite extensive laboratory selection of Vip3Aa-resistant colonies in Lepidoptera, the biochemical mechanisms underlying resistance have remained elusive. Our research identifies HaVipR1 as a potential contributor to resistance, adding to our understanding of how insects may develop resistance to this important Bt protein. The identification of HaVipR1 contributes to our understanding of potential resistance mechanisms and may inform future resistance management strategies. Future work should explore the biochemical pathways influenced by HaVipR1 and assess its interactions with other resistance mechanisms. The approach utilized here underscores the value of field-derived resistant lines for understanding resistance in agricultural pests and highlights the need for targeted approaches to manage resistance sustainably.
Related Topics
Concepts
Biology
Helicoverpa armigera
Bacillus thuringiensis
Cry1Ac
Bt cotton
Biotechnology
PEST analysis
Genetically modified crops
Resistance (ecology)
Genetics
Gene
Lepidoptera genitalia
Transgene
Agronomy
Botany
Bacteria
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pbio.3003165
- OA Status
- gold
- Cited By
- 6
- References
- 72
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410861046
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410861046Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pbio.3003165Digital Object Identifier
- Title
-
Disruption of HaVipR1 confers Vip3Aa resistance in the moth crop pest Helicoverpa armigeraWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-29Full publication date if available
- Authors
-
Andreas Bachler, Amanda Padovan, Craig Anderson, Yiyun Wei, Yidong Wu, Stephen L. Pearce, Sharon Downes, Bill James, Ashley E. Tessnow, Gregory A. Sword, Michelle Williams, Wee Tek Tay, Karl Gordon, Tom WalshList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pbio.3003165Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1371/journal.pbio.3003165Direct OA link when available
- Concepts
-
Biology, Helicoverpa armigera, Bacillus thuringiensis, Cry1Ac, Bt cotton, Biotechnology, PEST analysis, Genetically modified crops, Resistance (ecology), Genetics, Gene, Lepidoptera genitalia, Transgene, Agronomy, Botany, BacteriaTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6Per-year citation counts (last 5 years)
- References (count)
-
72Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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