Dissecting the Clonal Composition and Determinants of Neutralization Potency Enhancement of Serum Dimeric and Monomeric IgA to Human Norovirus Article Swipe
George Georgiou
,
Yaoska Reyes
,
Whitney Pickens
,
Mark R. Zweigart
,
Jan Vinjé
,
Jason J. Lavinder
,
Sean N. Tucker
,
Zunlong Ke
,
Ralph S. Baric
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-8066364/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-8066364/v1
Protection against human norovirus infection, which is the major cause of acute gastroenteritis, is strongly correlated with humoral immunity, particularly with IgA binding titers in serum and mucosal surfaces. Serum IgA is mostly monomeric (mIgA), with 10-20% present as dimeric (dIgA). Using serum antibody proteomics, we determined the clonal composition of the serum IgG, mIgA, and dIgA repertoires specific to GII.4 virus-like particles (VLPs) following oral vaccination with an adenoviral vectored norovirus vaccine candidate, which phenocopies the route of administration and the higher IgA to IgG serum titers associated with natural infection. We detected a low level of clonal overlap between circulating IgG and IgA at steady state, which, however, increased up to 65% following vaccination. Importantly, > 80% of serum mIgA specific to VLP was also found as dIgA, yet the mIgA:dIgA abundance ratio for different clonotypes varied by up to 250-fold (0.4190). We observed a similar congruence of the influenza hemagglutinin-binding dIgA and mIgA repertoires in serum following intramuscular flu vaccination. For antibodies targeting the apex, but not the lateral cleft, of the protruding (P) domain on human norovirus VLPs, IgA dimerization conferred markedly improved ligand blockade titers, resulting in higher potency towards the neutralization of live virus in the human intestinal enteroid system. Cryo-EM structures of prototypical apical and lateral cleft binding antibodies, coupled with cryo-ET imaging of VLP cross-linking mediated by dIgA, revealed that epitope accessibility, antibody binding orientation, and proximity to the attachment ligand binding site required for virus entry into host cells all influence the epitope-dependent differential potency of dIgA. Our findings elucidate key features of the molecular nature of the IgA serological response and the structural basis for the high neutralization potency of dIgA in an epitope-specific manner.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- article
- Landing Page
- https://doi.org/10.21203/rs.3.rs-8066364/v1
- https://www.researchsquare.com/article/rs-8066364/latest.pdf
- OA Status
- gold
- OpenAlex ID
- https://openalex.org/W4416909345
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4416909345Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-8066364/v1Digital Object Identifier
- Title
-
Dissecting the Clonal Composition and Determinants of Neutralization Potency Enhancement of Serum Dimeric and Monomeric IgA to Human NorovirusWork title
- Type
-
articleOpenAlex work type
- Publication year
-
2025Year of publication
- Publication date
-
2025-12-02Full publication date if available
- Authors
-
George Georgiou, Yaoska Reyes, Whitney Pickens, Mark R. Zweigart, Jan Vinjé, Jason J. Lavinder, Sean N. Tucker, Zunlong Ke, Ralph S. BaricList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-8066364/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-8066364/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-8066364/latest.pdfDirect OA link when available
- Cited by
-
0Total citation count in OpenAlex
Full payload
| id | https://openalex.org/W4416909345 |
|---|---|
| doi | https://doi.org/10.21203/rs.3.rs-8066364/v1 |
| ids.doi | https://doi.org/10.21203/rs.3.rs-8066364/v1 |
| ids.openalex | https://openalex.org/W4416909345 |
| fwci | |
| type | article |
| title | Dissecting the Clonal Composition and Determinants of Neutralization Potency Enhancement of Serum Dimeric and Monomeric IgA to Human Norovirus |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| language | |
| locations[0].id | doi:10.21203/rs.3.rs-8066364/v1 |
| locations[0].is_oa | True |
| locations[0].source | |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.researchsquare.com/article/rs-8066364/latest.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.21203/rs.3.rs-8066364/v1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5047788420 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8823-3073 |
| authorships[0].author.display_name | George Georgiou |
| authorships[0].affiliations[0].raw_affiliation_string | University of Texas |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | George Georgiou |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | University of Texas |
| authorships[1].author.id | https://openalex.org/A5072548978 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-9467-2438 |
| authorships[1].author.display_name | Yaoska Reyes |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA |
| authorships[1].institutions[0].id | https://openalex.org/I114027177 |
| authorships[1].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yaoska Reyes |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA |
| authorships[2].author.id | https://openalex.org/A5041762700 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6100-8231 |
| authorships[2].author.display_name | Whitney Pickens |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I86519309 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA |
| authorships[2].institutions[0].id | https://openalex.org/I86519309 |
| authorships[2].institutions[0].ror | https://ror.org/00hj54h04 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I86519309 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | The University of Texas at Austin |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Whitney Pickens |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA |
| authorships[3].author.id | https://openalex.org/A5073707234 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-5765-3203 |
| authorships[3].author.display_name | Mark R. Zweigart |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA |
| authorships[3].institutions[0].id | https://openalex.org/I114027177 |
| authorships[3].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Mark Zweigart |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA |
| authorships[4].author.id | https://openalex.org/A5046169053 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1530-3675 |
| authorships[4].author.display_name | Jan Vinjé |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1289490764 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Viral diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA |
| authorships[4].institutions[0].id | https://openalex.org/I1289490764 |
| authorships[4].institutions[0].ror | https://ror.org/042twtr12 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I1289490764, https://openalex.org/I1299022934 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Centers for Disease Control and Prevention |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jan Vinjé |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Division of Viral diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA |
| authorships[5].author.id | https://openalex.org/A5046080905 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-6044-1332 |
| authorships[5].author.display_name | Jason J. Lavinder |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I86519309 |
| authorships[5].affiliations[0].raw_affiliation_string | The University of Texas at Austin |
| authorships[5].institutions[0].id | https://openalex.org/I86519309 |
| authorships[5].institutions[0].ror | https://ror.org/00hj54h04 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I86519309 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | The University of Texas at Austin |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jason Lavinder |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | The University of Texas at Austin |
| authorships[6].author.id | https://openalex.org/A5018857037 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-6233-225X |
| authorships[6].author.display_name | Sean N. Tucker |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210129257 |
| authorships[6].affiliations[0].raw_affiliation_string | Vaxart Inc |
| authorships[6].institutions[0].id | https://openalex.org/I4210129257 |
| authorships[6].institutions[0].ror | https://ror.org/03qecha53 |
| authorships[6].institutions[0].type | company |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210129257 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Vaxart (United States) |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Sean Tucker |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Vaxart Inc |
| authorships[7].author.id | https://openalex.org/A5045735887 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8408-850X |
| authorships[7].author.display_name | Zunlong Ke |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I86519309 |
| authorships[7].affiliations[0].raw_affiliation_string | The University of Texas at Austin |
| authorships[7].institutions[0].id | https://openalex.org/I86519309 |
| authorships[7].institutions[0].ror | https://ror.org/00hj54h04 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I86519309 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | The University of Texas at Austin |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Zunlong Ke |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | The University of Texas at Austin |
| authorships[8].author.id | https://openalex.org/A5017501496 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-6827-8701 |
| authorships[8].author.display_name | Ralph S. Baric |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[8].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[8].institutions[0].id | https://openalex.org/I114027177 |
| authorships[8].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Ralph Baric |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | University of North Carolina at Chapel Hill |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.researchsquare.com/article/rs-8066364/latest.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-12-02T00:00:00 |
| display_name | Dissecting the Clonal Composition and Determinants of Neutralization Potency Enhancement of Serum Dimeric and Monomeric IgA to Human Norovirus |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-12-03T23:09:05.601824 |
| primary_topic | |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.21203/rs.3.rs-8066364/v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.researchsquare.com/article/rs-8066364/latest.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-8066364/v1 |
| primary_location.id | doi:10.21203/rs.3.rs-8066364/v1 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-8066364/latest.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-8066364/v1 |
| publication_date | 2025-12-02 |
| publication_year | 2025 |
| referenced_works_count | 0 |
| abstract_inverted_index.a | 95, 147 |
| abstract_inverted_index.We | 93, 145 |
| abstract_inverted_index.an | 69, 283 |
| abstract_inverted_index.as | 39, 129 |
| abstract_inverted_index.at | 106 |
| abstract_inverted_index.by | 140, 225 |
| abstract_inverted_index.in | 25, 158, 192, 201, 282 |
| abstract_inverted_index.is | 7, 14, 32 |
| abstract_inverted_index.of | 11, 51, 79, 98, 120, 150, 174, 198, 209, 221, 255, 262, 266, 280 |
| abstract_inverted_index.on | 179 |
| abstract_inverted_index.to | 60, 85, 113, 124, 142, 236 |
| abstract_inverted_index.up | 112, 141 |
| abstract_inverted_index.we | 46 |
| abstract_inverted_index.(P) | 177 |
| abstract_inverted_index.65% | 114 |
| abstract_inverted_index.80% | 119 |
| abstract_inverted_index.For | 164 |
| abstract_inverted_index.IgA | 22, 31, 84, 105, 183, 268 |
| abstract_inverted_index.IgG | 86, 103 |
| abstract_inverted_index.Our | 257 |
| abstract_inverted_index.VLP | 125, 222 |
| abstract_inverted_index.all | 249 |
| abstract_inverted_index.and | 27, 56, 81, 104, 155, 212, 234, 271 |
| abstract_inverted_index.but | 169 |
| abstract_inverted_index.flu | 162 |
| abstract_inverted_index.for | 136, 243, 275 |
| abstract_inverted_index.key | 260 |
| abstract_inverted_index.low | 96 |
| abstract_inverted_index.not | 170 |
| abstract_inverted_index.the | 8, 48, 52, 77, 82, 132, 151, 167, 171, 175, 196, 202, 237, 251, 263, 267, 272, 276 |
| abstract_inverted_index.was | 126 |
| abstract_inverted_index.yet | 131 |
| abstract_inverted_index.> | 118 |
| abstract_inverted_index.IgG, | 54 |
| abstract_inverted_index.also | 127 |
| abstract_inverted_index.dIgA | 57, 154, 281 |
| abstract_inverted_index.high | 277 |
| abstract_inverted_index.host | 247 |
| abstract_inverted_index.into | 246 |
| abstract_inverted_index.live | 199 |
| abstract_inverted_index.mIgA | 122, 156 |
| abstract_inverted_index.oral | 66 |
| abstract_inverted_index.site | 241 |
| abstract_inverted_index.that | 228 |
| abstract_inverted_index.with | 17, 21, 36, 68, 90, 218 |
| abstract_inverted_index.GII.4 | 61 |
| abstract_inverted_index.Serum | 30 |
| abstract_inverted_index.Using | 42 |
| abstract_inverted_index.VLPs, | 182 |
| abstract_inverted_index.acute | 12 |
| abstract_inverted_index.apex, | 168 |
| abstract_inverted_index.basis | 274 |
| abstract_inverted_index.cause | 10 |
| abstract_inverted_index.cells | 248 |
| abstract_inverted_index.cleft | 214 |
| abstract_inverted_index.dIgA, | 130, 226 |
| abstract_inverted_index.dIgA. | 256 |
| abstract_inverted_index.entry | 245 |
| abstract_inverted_index.found | 128 |
| abstract_inverted_index.human | 3, 180, 203 |
| abstract_inverted_index.level | 97 |
| abstract_inverted_index.mIgA, | 55 |
| abstract_inverted_index.major | 9 |
| abstract_inverted_index.ratio | 135 |
| abstract_inverted_index.route | 78 |
| abstract_inverted_index.serum | 26, 43, 53, 87, 121, 159 |
| abstract_inverted_index.virus | 200, 244 |
| abstract_inverted_index.which | 6, 75 |
| abstract_inverted_index.(VLPs) | 64 |
| abstract_inverted_index.10-20% | 37 |
| abstract_inverted_index.apical | 211 |
| abstract_inverted_index.cleft, | 173 |
| abstract_inverted_index.clonal | 49, 99 |
| abstract_inverted_index.domain | 178 |
| abstract_inverted_index.higher | 83, 193 |
| abstract_inverted_index.ligand | 188, 239 |
| abstract_inverted_index.mostly | 33 |
| abstract_inverted_index.nature | 265 |
| abstract_inverted_index.state, | 108 |
| abstract_inverted_index.steady | 107 |
| abstract_inverted_index.titers | 24, 88 |
| abstract_inverted_index.varied | 139 |
| abstract_inverted_index.which, | 109 |
| abstract_inverted_index.(dIgA). | 41 |
| abstract_inverted_index.(mIgA), | 35 |
| abstract_inverted_index.Cryo-EM | 207 |
| abstract_inverted_index.against | 2 |
| abstract_inverted_index.between | 101 |
| abstract_inverted_index.binding | 23, 215, 232, 240 |
| abstract_inverted_index.coupled | 217 |
| abstract_inverted_index.cryo-ET | 219 |
| abstract_inverted_index.dimeric | 40 |
| abstract_inverted_index.epitope | 229 |
| abstract_inverted_index.humoral | 18 |
| abstract_inverted_index.imaging | 220 |
| abstract_inverted_index.lateral | 172, 213 |
| abstract_inverted_index.manner. | 285 |
| abstract_inverted_index.mucosal | 28 |
| abstract_inverted_index.natural | 91 |
| abstract_inverted_index.overlap | 100 |
| abstract_inverted_index.potency | 194, 254, 279 |
| abstract_inverted_index.present | 38 |
| abstract_inverted_index.similar | 148 |
| abstract_inverted_index.system. | 206 |
| abstract_inverted_index.titers, | 190 |
| abstract_inverted_index.towards | 195 |
| abstract_inverted_index.vaccine | 73 |
| abstract_inverted_index.250-fold | 143 |
| abstract_inverted_index.antibody | 44, 231 |
| abstract_inverted_index.blockade | 189 |
| abstract_inverted_index.detected | 94 |
| abstract_inverted_index.enteroid | 205 |
| abstract_inverted_index.features | 261 |
| abstract_inverted_index.findings | 258 |
| abstract_inverted_index.however, | 110 |
| abstract_inverted_index.improved | 187 |
| abstract_inverted_index.markedly | 186 |
| abstract_inverted_index.mediated | 224 |
| abstract_inverted_index.observed | 146 |
| abstract_inverted_index.required | 242 |
| abstract_inverted_index.response | 270 |
| abstract_inverted_index.revealed | 227 |
| abstract_inverted_index.specific | 59, 123 |
| abstract_inverted_index.strongly | 15 |
| abstract_inverted_index.vectored | 71 |
| abstract_inverted_index.(0.4190). | 144 |
| abstract_inverted_index.abundance | 134 |
| abstract_inverted_index.conferred | 185 |
| abstract_inverted_index.different | 137 |
| abstract_inverted_index.elucidate | 259 |
| abstract_inverted_index.following | 65, 115, 160 |
| abstract_inverted_index.immunity, | 19 |
| abstract_inverted_index.increased | 111 |
| abstract_inverted_index.influence | 250 |
| abstract_inverted_index.influenza | 152 |
| abstract_inverted_index.mIgA:dIgA | 133 |
| abstract_inverted_index.molecular | 264 |
| abstract_inverted_index.monomeric | 34 |
| abstract_inverted_index.norovirus | 4, 72, 181 |
| abstract_inverted_index.particles | 63 |
| abstract_inverted_index.proximity | 235 |
| abstract_inverted_index.resulting | 191 |
| abstract_inverted_index.surfaces. | 29 |
| abstract_inverted_index.targeting | 166 |
| abstract_inverted_index.Protection | 1 |
| abstract_inverted_index.adenoviral | 70 |
| abstract_inverted_index.antibodies | 165 |
| abstract_inverted_index.associated | 89 |
| abstract_inverted_index.attachment | 238 |
| abstract_inverted_index.candidate, | 74 |
| abstract_inverted_index.clonotypes | 138 |
| abstract_inverted_index.congruence | 149 |
| abstract_inverted_index.correlated | 16 |
| abstract_inverted_index.determined | 47 |
| abstract_inverted_index.infection, | 5 |
| abstract_inverted_index.infection. | 92 |
| abstract_inverted_index.intestinal | 204 |
| abstract_inverted_index.protruding | 176 |
| abstract_inverted_index.structural | 273 |
| abstract_inverted_index.structures | 208 |
| abstract_inverted_index.virus-like | 62 |
| abstract_inverted_index.antibodies, | 216 |
| abstract_inverted_index.circulating | 102 |
| abstract_inverted_index.composition | 50 |
| abstract_inverted_index.phenocopies | 76 |
| abstract_inverted_index.proteomics, | 45 |
| abstract_inverted_index.repertoires | 58, 157 |
| abstract_inverted_index.serological | 269 |
| abstract_inverted_index.vaccination | 67 |
| abstract_inverted_index.Importantly, | 117 |
| abstract_inverted_index.differential | 253 |
| abstract_inverted_index.dimerization | 184 |
| abstract_inverted_index.orientation, | 233 |
| abstract_inverted_index.particularly | 20 |
| abstract_inverted_index.prototypical | 210 |
| abstract_inverted_index.vaccination. | 116, 163 |
| abstract_inverted_index.cross-linking | 223 |
| abstract_inverted_index.intramuscular | 161 |
| abstract_inverted_index.accessibility, | 230 |
| abstract_inverted_index.administration | 80 |
| abstract_inverted_index.neutralization | 197, 278 |
| abstract_inverted_index.epitope-specific | 284 |
| abstract_inverted_index.gastroenteritis, | 13 |
| abstract_inverted_index.epitope-dependent | 252 |
| abstract_inverted_index.hemagglutinin-binding | 153 |
| abstract_inverted_index.<title>Abstract</title> | 0 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile |