Dissociable spatial topography of neurodegeneration in Early‐onset and Late‐onset Alzheimer’s Disease: A head‐to‐head comparison of MRI‐derived atrophy measures between the LEADS and ADNI cohorts Article Swipe
Yuta Katsumi
,
Alexandra Touroutoglou
,
Michael Brickhouse
,
Ryan Eckbo
,
Renaud La Joie
,
Ani Eloyan
,
Kelly Nudelman
,
Tatiana Foroud
,
Jeffrey L. Dage
,
María C. Carrillo
,
Gil D. Rabinovici
,
Liana G. Apostolova
,
Bradford C. Dickerson
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/alz.094005
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/alz.094005
Background Understanding how early‐onset Alzheimer’s disease (EOAD) differs from typical late‐onset AD (LOAD) is an important goal of AD research that may help increase the sensitivity of unique biomarkers for each phenotype. Building upon prior work based on small samples, here we leveraged two large, well‐characterized natural history study cohorts of AD patients (LEADS and ADNI3) to test the hypothesis that EOAD patients would show more prominent lateral and medial parietal and lateral temporal cortical atrophy sparing the medial temporal lobe (MTL), whereas LOAD patients would show prominent MTL atrophy. Method We investigated differences in the spatial topography of cortical atrophy between EOAD and LOAD patients by analyzing structural MRI data collected from 211 patients with sporadic EOAD and 88 cognitively unimpaired (CU) participants from the LEADS cohort as well as 144 patients with LOAD and 365 CU participants from the ADNI3 cohort. MRI data were processed via FreeSurfer v6.0 to estimate cortical thickness for each participant. A direct comparison of cortical thickness was performed between EOAD and LOAD patients based on W‐scores (i.e., Z‐scores adjusted for age and sex relative to CU participants within each cohort) while controlling for MMSE total scores. All patients underwent amyloid PET with 18F‐Florbetaben or 18F‐Florbetapir and amyloid positivity was centrally determined by quantification‐supported visual read. Result As expected, a direct comparison of cortical thickness between patients with EOAD and LOAD revealed a double dissociation between AD clinical phenotype and localization of cortical atrophy: EOAD patients showed greater atrophy in widespread cortical areas including the inferior parietal lobule (EOAD marginal mean W‐score ± SEM = ‐1.33±0.08 vs. LOAD = ‐0.52±0.09, p<.001, η2 = .097), precuneus (‐1.66±0.09 vs. ‐0.59±0.10, p<.001, η2 = .13), and caudal middle frontal gyrus (‐1.65±0.08 vs. ‐0.90±0.10, p<.001, η2 = .074), whereas LOAD patients showed greater atrophy in the entorhinal/perirhinal cortex and temporal pole (‐1.00±0.09 vs. ‐1.41±0.11, p<.008, η2 = .019). Conclusion These findings demonstrate a clearly dissociable spatial pattern of neurodegeneration between EOAD and LOAD, supporting our previously developed LOAD and EOAD signatures of cortical atrophy, which underlies the distinct episodic memory and other cognitive characteristics of these AD clinical phenotypes.
Related Topics
Concepts
Atrophy
Early-onset Alzheimer's disease
Posterior cortical atrophy
Cohort
Temporal lobe
Medicine
Neurodegeneration
Magnetic resonance imaging
Cardiology
Alzheimer's disease
Neuroscience
Pathology
Disease
Internal medicine
Psychology
Dementia
Epilepsy
Radiology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/alz.094005
- OA Status
- hybrid
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406223500
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406223500Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/alz.094005Digital Object Identifier
- Title
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Dissociable spatial topography of neurodegeneration in Early‐onset and Late‐onset Alzheimer’s Disease: A head‐to‐head comparison of MRI‐derived atrophy measures between the LEADS and ADNI cohortsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
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2024-12-01Full publication date if available
- Authors
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Yuta Katsumi, Alexandra Touroutoglou, Michael Brickhouse, Ryan Eckbo, Renaud La Joie, Ani Eloyan, Kelly Nudelman, Tatiana Foroud, Jeffrey L. Dage, María C. Carrillo, Gil D. Rabinovici, Liana G. Apostolova, Bradford C. DickersonList of authors in order
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https://doi.org/10.1002/alz.094005Publisher landing page
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1002/alz.094005Direct OA link when available
- Concepts
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Atrophy, Early-onset Alzheimer's disease, Posterior cortical atrophy, Cohort, Temporal lobe, Medicine, Neurodegeneration, Magnetic resonance imaging, Cardiology, Alzheimer's disease, Neuroscience, Pathology, Disease, Internal medicine, Psychology, Dementia, Epilepsy, RadiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.inferior | 252 |
| abstract_inverted_index.marginal | 256 |
| abstract_inverted_index.parietal | 71, 253 |
| abstract_inverted_index.patients | 53, 63, 85, 106, 115, 133, 170, 195, 223, 242, 293 |
| abstract_inverted_index.relative | 181 |
| abstract_inverted_index.research | 20 |
| abstract_inverted_index.revealed | 228 |
| abstract_inverted_index.samples, | 40 |
| abstract_inverted_index.sporadic | 117 |
| abstract_inverted_index.temporal | 74, 80, 302 |
| abstract_inverted_index.W‐score | 258 |
| abstract_inverted_index.analyzing | 108 |
| abstract_inverted_index.centrally | 207 |
| abstract_inverted_index.cognitive | 345 |
| abstract_inverted_index.collected | 112 |
| abstract_inverted_index.developed | 329 |
| abstract_inverted_index.expected, | 215 |
| abstract_inverted_index.important | 16 |
| abstract_inverted_index.including | 250 |
| abstract_inverted_index.leveraged | 43 |
| abstract_inverted_index.performed | 165 |
| abstract_inverted_index.phenotype | 235 |
| abstract_inverted_index.precuneus | 271 |
| abstract_inverted_index.processed | 147 |
| abstract_inverted_index.prominent | 67, 88 |
| abstract_inverted_index.thickness | 154, 163, 221 |
| abstract_inverted_index.underlies | 338 |
| abstract_inverted_index.underwent | 196 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Conclusion | 311 |
| abstract_inverted_index.FreeSurfer | 149 |
| abstract_inverted_index.W‐scores | 173 |
| abstract_inverted_index.Z‐scores | 175 |
| abstract_inverted_index.biomarkers | 29 |
| abstract_inverted_index.comparison | 160, 218 |
| abstract_inverted_index.determined | 208 |
| abstract_inverted_index.hypothesis | 60 |
| abstract_inverted_index.p<.001, | 267, 275, 287 |
| abstract_inverted_index.p<.008, | 307 |
| abstract_inverted_index.phenotype. | 32 |
| abstract_inverted_index.positivity | 205 |
| abstract_inverted_index.previously | 328 |
| abstract_inverted_index.signatures | 333 |
| abstract_inverted_index.structural | 109 |
| abstract_inverted_index.supporting | 326 |
| abstract_inverted_index.topography | 98 |
| abstract_inverted_index.unimpaired | 122 |
| abstract_inverted_index.widespread | 247 |
| abstract_inverted_index.cognitively | 121 |
| abstract_inverted_index.controlling | 189 |
| abstract_inverted_index.demonstrate | 314 |
| abstract_inverted_index.differences | 94 |
| abstract_inverted_index.dissociable | 317 |
| abstract_inverted_index.phenotypes. | 351 |
| abstract_inverted_index.sensitivity | 26 |
| abstract_inverted_index.dissociation | 231 |
| abstract_inverted_index.investigated | 93 |
| abstract_inverted_index.late‐onset | 11 |
| abstract_inverted_index.localization | 237 |
| abstract_inverted_index.participant. | 157 |
| abstract_inverted_index.participants | 124, 139, 184 |
| abstract_inverted_index.Alzheimer’s | 5 |
| abstract_inverted_index.Understanding | 2 |
| abstract_inverted_index.early‐onset | 4 |
| abstract_inverted_index.‐1.33±0.08 | 262 |
| abstract_inverted_index.(‐1.00±0.09 | 304 |
| abstract_inverted_index.(‐1.65±0.08 | 284 |
| abstract_inverted_index.(‐1.66±0.09 | 272 |
| abstract_inverted_index.‐0.52±0.09, | 266 |
| abstract_inverted_index.‐0.59±0.10, | 274 |
| abstract_inverted_index.‐0.90±0.10, | 286 |
| abstract_inverted_index.‐1.41±0.11, | 306 |
| abstract_inverted_index.characteristics | 346 |
| abstract_inverted_index.18F‐Florbetaben | 200 |
| abstract_inverted_index.18F‐Florbetapir | 202 |
| abstract_inverted_index.neurodegeneration | 321 |
| abstract_inverted_index.well‐characterized | 46 |
| abstract_inverted_index.entorhinal/perirhinal | 299 |
| abstract_inverted_index.quantification‐supported | 210 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| citation_normalized_percentile.value | 0.47033076 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |