Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management Article Swipe
Rand Ghanma
,
Yara A. Naser
,
Qonita Kurnia Anjani
,
Akmal Hidayat Bin Sabri
,
Aaron R. J. Hutton
,
Lalitkumar K. Vora
,
Achmad Himawan
,
Natalia Moreno‐Castellanos
,
Brett Greer
,
Helen O. McCarthy
,
Alejandro J. Paredes
,
Ryan F. Donnelly
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijpharm.2024.124342
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijpharm.2024.124342
Schizophrenia is a psychiatric disorder that results from abnormal levels of neurotransmitters in the brain. Risperidone (RIS) is a common drug prescribed for the treatment of schizophrenia. RIS is a hydrophobic drug that is typically administered orally or intramuscularly. Transdermal drug delivery (TDD) could potentially improve the delivery of RIS. This study focused on the development of RIS nanocrystals (NCs), for the first time, which were incorporated into dissolving microneedle array patches (DMAPs) to facilitate the drug delivery of RIS. RIS NCs were formulated via wet-media milling technique using poly(vinylalcohol) (PVA) as a stabiliser. NCs with particle size of 300 nm were produced and showed an enhanced release profile up to 80 % over 28 days. Ex vivo results showed that 1.16 ± 0.04 mg of RIS was delivered to both the receiver compartment and full-thickness skin from NCs loaded DMAPs compared to 0.75 ± 0.07 mg from bulk RIS DMAPs. In an in vivo study conducted using female Sprague Dawley rats, both RIS and its active metabolite 9-hydroxyrisperidone (9-OH-RIS) were detected in plasma samples for 5 days. In comparison with the oral group, DMAPs improved the overall pharmacokinetic profile in plasma with a ∼ 15 folds higher area under the curve (AUC) value. This work has represented the novel delivery of the antipsychotic drug, RIS, through microneedles. It also offers substantial evidence to support the broader application of MAPs for the transdermal delivery of poorly water-soluble drugs.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ijpharm.2024.124342
- https://ars.els-cdn.com/content/image/1-s2.0-S0378517324005763-ga1_lrg.jpg
- OA Status
- hybrid
- Cited By
- 11
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399697955
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4399697955Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.ijpharm.2024.124342Digital Object Identifier
- Title
-
Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia managementWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-06-15Full publication date if available
- Authors
-
Rand Ghanma, Yara A. Naser, Qonita Kurnia Anjani, Akmal Hidayat Bin Sabri, Aaron R. J. Hutton, Lalitkumar K. Vora, Achmad Himawan, Natalia Moreno‐Castellanos, Brett Greer, Helen O. McCarthy, Alejandro J. Paredes, Ryan F. DonnellyList of authors in order
- Landing page
-
https://doi.org/10.1016/j.ijpharm.2024.124342Publisher landing page
- PDF URL
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https://ars.els-cdn.com/content/image/1-s2.0-S0378517324005763-ga1_lrg.jpgDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
- OA URL
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https://ars.els-cdn.com/content/image/1-s2.0-S0378517324005763-ga1_lrg.jpgDirect OA link when available
- Concepts
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Transdermal, Risperidone, Pharmacokinetics, Pharmacology, Drug delivery, In vivo, Ex vivo, Drug, Medicine, Chemistry, Biomedical engineering, Materials science, Schizophrenia (object-oriented programming), In vitro, Nanotechnology, Biochemistry, Psychiatry, Biotechnology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 5Per-year citation counts (last 5 years)
- References (count)
-
73Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.(PVA) | 90 |
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