Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus Article Swipe
Fabiola F. Mehta
,
Jieun Son
,
Sylvia C. Hewitt
,
Eun‐Jung Jang
,
John P. Lydon
,
Kenneth S. Korach
,
Sang‐Hyuk Chung
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.8159
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.8159
While the function of progesterone receptor (PR) has been studied in the mouse vagina and uterus, its regulation and function in the cervix has not been described. We selectively deleted epithelial PR in the female reproductive tracts using the Cre/LoxP recombination system. We found that epithelial PR was required for induction of apoptosis and suppression of cell proliferation by progesterone (P4) in the cervical and vaginal epithelium. We also found that epithelial PR was dispensable for P4 to suppress apoptosis and proliferation in the uterine epithelium. PR is encoded by the Pgr gene, which is regulated by estrogen receptor α (ERα) in the female reproductive tracts. Using knock-in mouse models expressing ERα mutants, we determined that the DNA-binding domain (DBD) and AF2 domain of ERα were required for upregulation of Pgr in the cervix and vagina as well as the uterine stroma. The ERα AF1 domain was required for upregulation of Pgr in the vaginal stroma and epithelium and cervical epithelium, but not in the uterine and cervical stroma. ERα DBD, AF1, and AF2 were required for suppression of Pgr in the uterine epithelium, which was mediated by stromal ERα. Epithelial ERα was responsible for upregulation of epithelial Pgr in the cervix and vagina. Our results indicate that regulation and functions of epithelial PR are different in the cervix, vagina, and uterus.
Related Topics
Concepts
Vagina
Uterus
Cervix
Progesterone receptor
Medicine
Receptor
Epithelium
Gynecology
Uterine cervix
Andrology
Biology
Internal medicine
Pathology
Anatomy
Cancer
Estrogen receptor
Carcinoma
Breast cancer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/oncotarget.8159
- OA Status
- diamond
- Cited By
- 46
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2322223176
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2322223176Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.18632/oncotarget.8159Digital Object Identifier
- Title
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Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterusWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
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2016-03-17Full publication date if available
- Authors
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Fabiola F. Mehta, Jieun Son, Sylvia C. Hewitt, Eun‐Jung Jang, John P. Lydon, Kenneth S. Korach, Sang‐Hyuk ChungList of authors in order
- Landing page
-
https://doi.org/10.18632/oncotarget.8159Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.18632/oncotarget.8159Direct OA link when available
- Concepts
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Vagina, Uterus, Cervix, Progesterone receptor, Medicine, Receptor, Epithelium, Gynecology, Uterine cervix, Andrology, Biology, Internal medicine, Pathology, Anatomy, Cancer, Estrogen receptor, Carcinoma, Breast cancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
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46Total citation count in OpenAlex
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2025: 2, 2024: 11, 2023: 6, 2022: 8, 2021: 4Per-year citation counts (last 5 years)
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39Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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