Distinct metastatic organotropism shapes prognosis in lung adenocarcinoma with brain metastasis Article Swipe
Sama I. Sayin
,
Ella Ä. Eklund
,
Kevin X. Ali
,
Jozefina J. Dzanan
,
Moe Xylander
,
Martin Dankis
,
Per Lindahl
,
Volkan I. Sayin
,
Andreas Hallqvist
,
Clotilde Wiel
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.02.25.25322889
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.02.25.25322889
Background Metastatic organotropism in lung cancer significantly influences prognosis, yet current treatment and clinical management guidelines are largely generalized for metastatic disease, regardless of organ site involvement. Notably, up to 30% of non-small cell lung cancer (NSCLC) patients present with brain metastases (BM) at diagnosis, underscoring the need for a more nuanced understanding of metastatic patterns. However, real-world clinical data on metastatic organotropism in well-characterized patient cohorts remain surprisingly scarce. Here, we evaluate patterns of metastasis, clinical characteristics and survival outcomes in patients with lung adenocarcinoma (LUAD), the major histological NSCLC subtype. Methods We performed a multi-center retrospective study including 913 stage IV LUAD patients, diagnosed and molecularly assessed in western Sweden between 2016 and 2021. Our primary study outcome was the distribution of specific metastatic sites and its impact on Overall Survival (OS). Results Out of 913 stage IV LUAD patients, 23.4% had BM. These patients exhibited markedly different metastatic patterns compared to those without BM, and median survival was significantly shorter (6 months) than those without BM (7.8 months) ( p = 0.021). In addition, more than one metastatic tumor in the brain coincided with worse OS, compared to those with no, or with only one metastatic tumor in the brain. Importantly, OS was also influenced by metastasis in specific extracranial organs, like the pleura and lungs. Conclusions Our study highlights the distinct metastatic patterns and survival outcomes associated with BM in stage IV LUAD. These findings emphasize the need for site-specific approaches in managing metastatic disease due to the impact of BM on survival.
Related Topics
Concepts
Brain metastasis
Adenocarcinoma
Medicine
Metastasis
Lung
Oncology
Adenocarcinoma of the lung
Internal medicine
Pathology
Cancer
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.02.25.25322889
- https://www.medrxiv.org/content/medrxiv/early/2025/02/26/2025.02.25.25322889.full.pdf
- OA Status
- green
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408006238
All OpenAlex metadata
Raw OpenAlex JSON
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https://doi.org/10.1101/2025.02.25.25322889Digital Object Identifier
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Distinct metastatic organotropism shapes prognosis in lung adenocarcinoma with brain metastasisWork title
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preprintOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-02-26Full publication date if available
- Authors
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Sama I. Sayin, Ella Ä. Eklund, Kevin X. Ali, Jozefina J. Dzanan, Moe Xylander, Martin Dankis, Per Lindahl, Volkan I. Sayin, Andreas Hallqvist, Clotilde WielList of authors in order
- Landing page
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https://doi.org/10.1101/2025.02.25.25322889Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2025/02/26/2025.02.25.25322889.full.pdfDirect link to full text PDF
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greenOpen access status per OpenAlex
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https://www.medrxiv.org/content/medrxiv/early/2025/02/26/2025.02.25.25322889.full.pdfDirect OA link when available
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Brain metastasis, Adenocarcinoma, Medicine, Metastasis, Lung, Oncology, Adenocarcinoma of the lung, Internal medicine, Pathology, CancerTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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29Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.brain. | 203 |
| abstract_inverted_index.cancer | 6, 36 |
| abstract_inverted_index.impact | 130, 253 |
| abstract_inverted_index.lungs. | 219 |
| abstract_inverted_index.median | 159 |
| abstract_inverted_index.pleura | 217 |
| abstract_inverted_index.remain | 68 |
| abstract_inverted_index.(LUAD), | 87 |
| abstract_inverted_index.(NSCLC) | 37 |
| abstract_inverted_index.0.021). | 175 |
| abstract_inverted_index.Methods | 93 |
| abstract_inverted_index.Overall | 132 |
| abstract_inverted_index.Results | 135 |
| abstract_inverted_index.between | 113 |
| abstract_inverted_index.cohorts | 67 |
| abstract_inverted_index.current | 11 |
| abstract_inverted_index.disease | 249 |
| abstract_inverted_index.largely | 18 |
| abstract_inverted_index.months) | 165, 171 |
| abstract_inverted_index.nuanced | 52 |
| abstract_inverted_index.organs, | 214 |
| abstract_inverted_index.outcome | 120 |
| abstract_inverted_index.patient | 66 |
| abstract_inverted_index.present | 39 |
| abstract_inverted_index.primary | 118 |
| abstract_inverted_index.scarce. | 70 |
| abstract_inverted_index.shorter | 163 |
| abstract_inverted_index.western | 111 |
| abstract_inverted_index.without | 156, 168 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 57 |
| abstract_inverted_index.Notably, | 28 |
| abstract_inverted_index.Survival | 133 |
| abstract_inverted_index.assessed | 109 |
| abstract_inverted_index.clinical | 14, 59, 77 |
| abstract_inverted_index.compared | 153, 190 |
| abstract_inverted_index.disease, | 22 |
| abstract_inverted_index.distinct | 225 |
| abstract_inverted_index.evaluate | 73 |
| abstract_inverted_index.findings | 239 |
| abstract_inverted_index.managing | 247 |
| abstract_inverted_index.markedly | 149 |
| abstract_inverted_index.outcomes | 81, 230 |
| abstract_inverted_index.patients | 38, 83, 147 |
| abstract_inverted_index.patterns | 74, 152, 227 |
| abstract_inverted_index.specific | 125, 212 |
| abstract_inverted_index.subtype. | 92 |
| abstract_inverted_index.survival | 80, 160, 229 |
| abstract_inverted_index.addition, | 177 |
| abstract_inverted_index.coincided | 186 |
| abstract_inverted_index.diagnosed | 106 |
| abstract_inverted_index.different | 150 |
| abstract_inverted_index.emphasize | 240 |
| abstract_inverted_index.exhibited | 148 |
| abstract_inverted_index.including | 100 |
| abstract_inverted_index.non-small | 33 |
| abstract_inverted_index.patients, | 105, 142 |
| abstract_inverted_index.patterns. | 56 |
| abstract_inverted_index.performed | 95 |
| abstract_inverted_index.survival. | 257 |
| abstract_inverted_index.treatment | 12 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Metastatic | 2 |
| abstract_inverted_index.approaches | 245 |
| abstract_inverted_index.associated | 231 |
| abstract_inverted_index.diagnosis, | 45 |
| abstract_inverted_index.guidelines | 16 |
| abstract_inverted_index.highlights | 223 |
| abstract_inverted_index.influenced | 208 |
| abstract_inverted_index.influences | 8 |
| abstract_inverted_index.management | 15 |
| abstract_inverted_index.metastases | 42 |
| abstract_inverted_index.metastasis | 210 |
| abstract_inverted_index.metastatic | 21, 55, 62, 126, 151, 181, 199, 226, 248 |
| abstract_inverted_index.prognosis, | 9 |
| abstract_inverted_index.real-world | 58 |
| abstract_inverted_index.regardless | 23 |
| abstract_inverted_index.Conclusions | 220 |
| abstract_inverted_index.generalized | 19 |
| abstract_inverted_index.metastasis, | 76 |
| abstract_inverted_index.molecularly | 108 |
| abstract_inverted_index.Importantly, | 204 |
| abstract_inverted_index.distribution | 123 |
| abstract_inverted_index.extracranial | 213 |
| abstract_inverted_index.histological | 90 |
| abstract_inverted_index.involvement. | 27 |
| abstract_inverted_index.multi-center | 97 |
| abstract_inverted_index.surprisingly | 69 |
| abstract_inverted_index.underscoring | 46 |
| abstract_inverted_index.organotropism | 3, 63 |
| abstract_inverted_index.retrospective | 98 |
| abstract_inverted_index.significantly | 7, 162 |
| abstract_inverted_index.site-specific | 244 |
| abstract_inverted_index.understanding | 53 |
| abstract_inverted_index.adenocarcinoma | 86 |
| abstract_inverted_index.characteristics | 78 |
| abstract_inverted_index.well-characterized | 65 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 10 |
| citation_normalized_percentile.value | 0.08634389 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |