Distinct Recovery Patterns After Transforaminal Lumbar Interbody Fusion: Comparing Minimally Invasive and Open Approaches Using Mixed-Effects Segmented Regression Article Swipe
Tomoyuki Asada
,
Eric Zhao
,
Annette Ehrlich
,
Adrian Lui
,
Andrea Pezzi
,
Sereen Halayqeh
,
Tarek Harhash
,
Olivia Tuma
,
Kasra Araghi
,
Todd J. Albert
,
James C. Farmer
,
Russel C. Huang
,
Harvinder S. Sandhu
,
Han Jo Kim
,
Francis Lovecchio
,
James Dowdell
,
Sravisht Iyer
,
Sheeraz A. Qureshi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.14245/ns.2550096.048
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.14245/ns.2550096.048
Objective: While minimally invasive-transforaminal lumbar interbody fusion (MIS-TLIF) has shown superiority in key clinical metrics over the open approach, evidence regarding patient-reported outcomes remains limited. This study compared postoperative recovery trajectories and symptomatic improvement phases between MIS and open TLIF.Methods: This retrospective review included patients who underwent single-level MIS or open TLIF. Oswestry Disability Index (ODI) and Numerical Rating Scale (NRS) for back and leg pain were collected preoperatively and postoperatively. Segmented regression analysis with mixed-effects modeling, allowing for identification of distinct recovery phases, compared symptomatic trends between approaches.Results: Of 324 patients (268 MIS, 56 open), baseline demographics were similar except for greater preoperative leg pain in the MIS group (NRS: 6.0 vs. 5.0, p = 0.027). A segmented regression model identified 4 ODI recovery phases: postoperative disability phase (PDP, day 0 to 13), early improvement phase (day 13 to 28), late improvement phase (day 28 to 110), and plateau phase (later than day 110). The MIS group exhibited significantly lower disability exacerbation during PDP (β = 0.93 vs. 1.42 points per day, p = 0.008). Additionally, the plateau of NRS back occurred significantly earlier in the MIS group than in the open group (MIS, 26.7 ± 2.6 days vs. open, 51.7 ± 6.6 days, p < 0.001).Conclusion: MIS-TLIF resulted in lower postoperative disability during the first 2 weeks compared to the open approach. Furthermore, low back pain achieved an earlier plateau in back pain by about 4 weeks in the MIS approach.
Related Topics
Concepts
Medicine
Oswestry Disability Index
Surgery
Lumbar
Back pain
Low back pain
Anesthesia
Pathology
Alternative medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.14245/ns.2550096.048
- https://www.e-neurospine.org/upload/pdf/ns-2550096-048.pdf
- OA Status
- diamond
- Cited By
- 2
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408989174
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4408989174Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.14245/ns.2550096.048Digital Object Identifier
- Title
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Distinct Recovery Patterns After Transforaminal Lumbar Interbody Fusion: Comparing Minimally Invasive and Open Approaches Using Mixed-Effects Segmented RegressionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-31Full publication date if available
- Authors
-
Tomoyuki Asada, Eric Zhao, Annette Ehrlich, Adrian Lui, Andrea Pezzi, Sereen Halayqeh, Tarek Harhash, Olivia Tuma, Kasra Araghi, Todd J. Albert, James C. Farmer, Russel C. Huang, Harvinder S. Sandhu, Han Jo Kim, Francis Lovecchio, James Dowdell, Sravisht Iyer, Sheeraz A. QureshiList of authors in order
- Landing page
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https://doi.org/10.14245/ns.2550096.048Publisher landing page
- PDF URL
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https://www.e-neurospine.org/upload/pdf/ns-2550096-048.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://www.e-neurospine.org/upload/pdf/ns-2550096-048.pdfDirect OA link when available
- Concepts
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Medicine, Oswestry Disability Index, Surgery, Lumbar, Back pain, Low back pain, Anesthesia, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
- References (count)
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28Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.preoperative | 103 |
| abstract_inverted_index.single-level | 47 |
| abstract_inverted_index.trajectories | 30 |
| abstract_inverted_index.Additionally, | 176 |
| abstract_inverted_index.TLIF.Methods: | 39 |
| abstract_inverted_index.mixed-effects | 75 |
| abstract_inverted_index.postoperative | 28, 126, 212 |
| abstract_inverted_index.retrospective | 41 |
| abstract_inverted_index.significantly | 159, 183 |
| abstract_inverted_index.identification | 79 |
| abstract_inverted_index.preoperatively | 68 |
| abstract_inverted_index.patient-reported | 21 |
| abstract_inverted_index.postoperatively. | 70 |
| abstract_inverted_index.0.001).Conclusion: | 207 |
| abstract_inverted_index.approaches.Results: | 88 |
| abstract_inverted_index.invasive-transforaminal | 3 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 18 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.93346227 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |