Distinct AQP4 Alterations in Movement Disorders with Primary Synucleinopathy
Article Swipe
Lingbing Wang
,
Onur Tanglay
,
Fong‐Chin Su
,
Hongyun Li
,
Jun Liu
,
Woojin S. Kim
,
Glenda M. Halliday
,
YuHong Fu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/mds.70023
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/mds.70023
Background Aquaporin‐4 (AQP4) is involved in clearing amyloidogenic proteins, but it remains unexplored how it is comparatively altered in neuron‐ and oligodendrocyte‐predominant synucleinopathies. Objective The aim was to assess AQP4 protein localization and abundance in Parkinson's disease (PD) and multiple system atrophy (MSA). Methods The motor cortex and subcortical white matter of PD (n = 29), MSA (n = 19), and controls (n = 17) were immunohistochemically analyzed. Results In normal aging, neuritic plaques caused an increase in AQP4 abundance without altering polarization. Arteriolosclerosis and immunosuppressant medications had no impact. AQP4 endfeet recruitment decreased in early PD but recovered in late PD by enhanced polarization. AQP4 was depolarized in MSA‐parkinsonian type, but unaffected in MSA‐cerebellar type, with both preserved AQP4 endfeet recruitment. In controls with neuritic plaques and PD, AQP4 changes were predominantly in superficial cortical layers, with no regional preference in MSA. Conclusion The distinct AQP4 changes in neuronal and glial synucleinopathies underscore different pathomechanisms, warranting further investigation. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/mds.70023
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.70023
- OA Status
- hybrid
- References
- 38
- Related Works
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- OpenAlex ID
- https://openalex.org/W4413745158
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https://doi.org/10.1002/mds.70023Digital Object Identifier
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AQP4 Alterations in Movement Disorders with Primary SynucleinopathyWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-27Full publication date if available
- Authors
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Lingbing Wang, Onur Tanglay, Fong‐Chin Su, Hongyun Li, Jun Liu, Woojin S. Kim, Glenda M. Halliday, YuHong FuList of authors in order
- Landing page
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https://doi.org/10.1002/mds.70023Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.70023Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.70023Direct OA link when available
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Neuroscience, Movement disorders, Primary (astronomy), Movement (music), Medicine, Psychology, Pathology, Disease, Physics, Astronomy, AcousticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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