Ditopic Aza-Scorpiand Ligands Interact Selectively with ds-RNA and Modulate the Interaction upon Formation of Zn2+ Complexes Article Swipe
Lluís Guijarro
,
Álvaro Martínez‐Camarena
,
Javier U. Chicote
,
Antonio Garcı́a-España
,
Enrique Garcı́a-España
,
Mario Inclán
,
Begoña Verdejo
,
Jorge González‐García
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/molecules26133957
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/molecules26133957
Nucleic acids are essential biomolecules in living systems and represent one of the main targets of chemists, biophysics, biologists, and nanotechnologists. New small molecules are continuously developed to target the duplex (ds) structure of DNA and, most recently, RNA to be used as therapeutics and/or biological tools. Stimuli-triggered systems can promote and hamper the interaction to biomolecules through external stimuli such as light and metal coordination. In this work, we report on the interaction with ds-DNA and ds-RNA of two aza-macrocycles able to coordinate Zn2+ metal ions and form binuclear complexes. The interaction of the aza-macrocycles and the Zn2+ metal complexes with duplex DNA and RNA was studied using UV thermal and fluorescence indicator displacement assays in combination with theoretical studies. Both ligands show a high affinity for ds-DNA/RNA and selectivity for ds-RNA. The ability to interact with these duplexes is blocked upon Zn2+ coordination, which was confirmed by the low variation in the melting temperature and poor displacement of the fluorescent dye from the ds-DNA/RNA. Cell viability assays show a decrease in the cytotoxicity of the metal complexes in comparison with the free ligands, which can be associated with the observed binding to the nucleic acids.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules26133957
- https://www.mdpi.com/1420-3049/26/13/3957/pdf?version=1625117334
- OA Status
- gold
- Cited By
- 2
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3174890014
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- OpenAlex ID
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https://openalex.org/W3174890014Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/molecules26133957Digital Object Identifier
- Title
-
Ditopic Aza-Scorpiand Ligands Interact Selectively with ds-RNA and Modulate the Interaction upon Formation of Zn2+ ComplexesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-28Full publication date if available
- Authors
-
Lluís Guijarro, Álvaro Martínez‐Camarena, Javier U. Chicote, Antonio Garcı́a-España, Enrique Garcı́a-España, Mario Inclán, Begoña Verdejo, Jorge González‐GarcíaList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules26133957Publisher landing page
- PDF URL
-
https://www.mdpi.com/1420-3049/26/13/3957/pdf?version=1625117334Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1420-3049/26/13/3957/pdf?version=1625117334Direct OA link when available
- Concepts
-
Nucleic acid, RNA, DNA, Biomolecule, Chemistry, Duplex (building), Biophysics, Fluorescence, Small molecule, Metal ions in aqueous solution, Molecule, Metal, Stereochemistry, Combinatorial chemistry, Biochemistry, Biology, Gene, Organic chemistry, Physics, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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38Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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