Divergence of duplicated genes by repeated partitioning of splice forms and subcellular localization Article Swipe
Yichun Qiu
,
Yii Van Tay
,
Yuan Ruan
,
Keith L. Adams
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1111/nph.16148
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1111/nph.16148
Summary Gene duplication is a prominent and recurrent process in plant genomes. Among the possible fates of duplicated genes, subfunctionalization refers to duplicates taking on different parts of the function or expression pattern of the ancestral gene. This partitioning could be accompanied by changes in subcellular localization of the protein products. When alternative splicing of gene products leads to protein products with different subcellular localizations, we propose that after gene duplication there will be partitioning of the alternatively spliced forms such that the products of each duplicate are localized to only one of the original locations, which we refer to as sublocalization. We identified the plastid ascorbate peroxidase ( cpAPX ) genes across angiosperms and analyzed their duplication history, alternative splicing, and subcellular targeting patterns to identify cases of sublocalization. We found angiosperms typically have one cpAPX gene that generates both thylakoidal APX (tAPX) and stromal APX (sAPX) through alternative splicing. We identified several independent lineage‐specific sublocalization cases with specialized paralogues of tAPX and sAPX. We determined that the sublocalization happened through two types of sequence evolution patterns. Our findings suggest that the divergence through sublocalization is key to the retention of paralogous cpAPX genes in angiosperms.
Related Topics
Concepts
Gene duplication
Biology
Subfunctionalization
Gene
Alternative splicing
Genetics
Genome
Functional divergence
Lineage (genetic)
Subcellular localization
Plastid
Protein subcellular localization prediction
Tandem exon duplication
Segmental duplication
Exon
Gene family
Computational biology
Chloroplast
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/nph.16148
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/nph.16148
- OA Status
- bronze
- Cited By
- 27
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2970412190
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2970412190Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/nph.16148Digital Object Identifier
- Title
-
Divergence of duplicated genes by repeated partitioning of splice forms and subcellular localizationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-08-30Full publication date if available
- Authors
-
Yichun Qiu, Yii Van Tay, Yuan Ruan, Keith L. AdamsList of authors in order
- Landing page
-
https://doi.org/10.1111/nph.16148Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/nph.16148Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/nph.16148Direct OA link when available
- Concepts
-
Gene duplication, Biology, Subfunctionalization, Gene, Alternative splicing, Genetics, Genome, Functional divergence, Lineage (genetic), Subcellular localization, Plastid, Protein subcellular localization prediction, Tandem exon duplication, Segmental duplication, Exon, Gene family, Computational biology, ChloroplastTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
27Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 4, 2023: 1, 2022: 6, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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