Divergent amplifications of CYP9A cytochrome P450 genes provide two noctuid pests with differential protection against xenobiotics Article Swipe
Yu Shi
,
Qingqing Liu
,
Wenjie Lu
,
Jing Yuan
,
Yihua Yang
,
John G. Oakeshott
,
Yidong Wu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2308685120
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2308685120
Here, we provide mechanistic support for the involvement of the CYP9A subfamily of cytochrome P450 monooxygenases in the detoxification of host plant defense compounds and chemical insecticides in Spodoptera exigua and Spodoptera frugiperda . Our comparative genomics shows that a large cluster of CYP9A genes occurs in the two species but with significant differences in its contents, including several species-specific duplicates and substantial sequence divergence, both between orthologs and between duplicates. Bioassays of CRISPR-Cas9 knockouts of the clusters show that, collectively, the CYP9As can detoxify two furanocoumarin plant defense compounds (imperatorin and xanthotoxin) and insecticides representing three different chemotypes (pyrethroids, avermectins, and oxadiazines). However, in vitro metabolic assays of heterologously expressed products of individual genes show several differences between the species in the particular CYP9As with activities against these compounds. We also find that the clusters show tight genetic linkage with high levels of pyrethroid resistance in field strains of the two species. We propose that their divergent amplifications of the CYP9A subfamily have not only contributed to the development of the broad host ranges of these species over long evolutionary timeframes but also supplied them with diverse genetic options for evolving resistance to chemical insecticides in the very recent past.
Related Topics
Concepts
Biology
Spodoptera
Subfamily
Pyrethroid
Genetics
Monooxygenase
Gene
Cytochrome P450
Pesticide
Biochemistry
Ecology
Metabolism
Recombinant DNA
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2308685120
- OA Status
- green
- Cited By
- 66
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386453129
All OpenAlex metadata
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https://openalex.org/W4386453129Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1073/pnas.2308685120Digital Object Identifier
- Title
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Divergent amplifications of CYP9A cytochrome P450 genes provide two noctuid pests with differential protection against xenobioticsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-09-05Full publication date if available
- Authors
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Yu Shi, Qingqing Liu, Wenjie Lu, Jing Yuan, Yihua Yang, John G. Oakeshott, Yidong WuList of authors in order
- Landing page
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https://doi.org/10.1073/pnas.2308685120Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10500183/pdf/pnas.202308685.pdfDirect OA link when available
- Concepts
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Biology, Spodoptera, Subfamily, Pyrethroid, Genetics, Monooxygenase, Gene, Cytochrome P450, Pesticide, Biochemistry, Ecology, Metabolism, Recombinant DNATop concepts (fields/topics) attached by OpenAlex
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66Total citation count in OpenAlex
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2025: 39, 2024: 26, 2023: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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