Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated Functions Article Swipe
Elin Rönnberg
,
Avan Ghaib
,
Carlos Ceriol
,
Mattias Enoksson
,
Michel Arock
,
Jesper Säfholm
,
Maria Ekoff
,
Gunnar Nilsson
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2019.01361
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2019.01361
Background: Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic inflammation-related conditions such as asthma. Mast cells are one of the major targets of IL-33, to which they respond by secreting cytokines. Most studies performed thus far have investigated the acute effects of IL-33 on mast cells. In the current study, we investigated how acute vs. prolonged exposure of mast cells to IL-33 and TSLP affects mediator synthesis and IgE-mediated activation. Methods: Human lung mast cells (HLMCs), cord blood-derived mast cells (CBMCs), and the ROSA mast cell line were used for this study. Receptor expression and the levels of mediators were measured after treatment with IL-33 and/or TSLP. Results: IL-33 induced the release of cytokines. Prolonged exposure to IL-33 increased while TSLP reduced intracellular levels of tryptase. Acute IL-33 treatment strongly potentiated IgE-mediated activation. In contrast, 4 days of exposure to IL-33 decreased IgE-mediated activation, an effect that was accompanied by a reduction in FcεRI expression. Conclusion: We show that IL-33 plays dual roles in mast cells, in which its acute effects include cytokine release and the potentiation of IgE-mediated degranulation, whereas prolonged exposure to IL-33 reduces IgE-mediated activation. We conclude that mast cells act quickly in response to the alarmin IL-33 to initiate an acute inflammatory response, whereas extended exposure to IL-33 during prolonged inflammation reduces IgE-mediated responses. This negative feedback effect suggests the presence of a novel regulatory pathway that modulates IgE-mediated human mast cell responses.
Related Topics
Concepts
Mast cell
Immunoglobulin E
Immunology
Interleukin 33
Interleukin
Medicine
Interleukin 4
Cytokine
Antibody
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2019.01361
- OA Status
- gold
- Cited By
- 38
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2951460425
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2951460425Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2019.01361Digital Object Identifier
- Title
-
Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated FunctionsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
-
2019-06-19Full publication date if available
- Authors
-
Elin Rönnberg, Avan Ghaib, Carlos Ceriol, Mattias Enoksson, Michel Arock, Jesper Säfholm, Maria Ekoff, Gunnar NilssonList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2019.01361Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fimmu.2019.01361Direct OA link when available
- Concepts
-
Mast cell, Immunoglobulin E, Immunology, Interleukin 33, Interleukin, Medicine, Interleukin 4, Cytokine, AntibodyTop concepts (fields/topics) attached by OpenAlex
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38Total citation count in OpenAlex
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2025: 4, 2024: 4, 2023: 7, 2022: 3, 2021: 12Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.4 | 146 |
| abstract_inverted_index.a | 161, 237 |
| abstract_inverted_index.In | 57, 144 |
| abstract_inverted_index.We | 167, 199 |
| abstract_inverted_index.an | 155, 214 |
| abstract_inverted_index.as | 23 |
| abstract_inverted_index.by | 39, 160 |
| abstract_inverted_index.in | 17, 163, 174, 177, 206 |
| abstract_inverted_index.of | 14, 29, 33, 52, 68, 108, 123, 135, 148, 188, 236 |
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| abstract_inverted_index.to | 35, 71, 127, 150, 194, 208, 212, 221 |
| abstract_inverted_index.we | 61 |
| abstract_inverted_index.act | 204 |
| abstract_inverted_index.and | 5, 73, 78, 92, 105, 185 |
| abstract_inverted_index.are | 27 |
| abstract_inverted_index.far | 46 |
| abstract_inverted_index.for | 100 |
| abstract_inverted_index.how | 63 |
| abstract_inverted_index.its | 179 |
| abstract_inverted_index.one | 28 |
| abstract_inverted_index.the | 30, 49, 58, 93, 106, 121, 186, 209, 234 |
| abstract_inverted_index.vs. | 65 |
| abstract_inverted_index.was | 158 |
| abstract_inverted_index.Mast | 25 |
| abstract_inverted_index.Most | 42 |
| abstract_inverted_index.ROSA | 94 |
| abstract_inverted_index.TSLP | 74, 131 |
| abstract_inverted_index.This | 229 |
| abstract_inverted_index.cell | 96, 246 |
| abstract_inverted_index.cord | 87 |
| abstract_inverted_index.days | 147 |
| abstract_inverted_index.dual | 172 |
| abstract_inverted_index.have | 10, 47 |
| abstract_inverted_index.line | 97 |
| abstract_inverted_index.lung | 83 |
| abstract_inverted_index.mast | 55, 69, 84, 89, 95, 175, 202, 245 |
| abstract_inverted_index.show | 168 |
| abstract_inverted_index.such | 22 |
| abstract_inverted_index.that | 157, 169, 201, 241 |
| abstract_inverted_index.they | 37 |
| abstract_inverted_index.this | 101 |
| abstract_inverted_index.thus | 45 |
| abstract_inverted_index.used | 99 |
| abstract_inverted_index.were | 98, 110 |
| abstract_inverted_index.with | 114 |
| abstract_inverted_index.Acute | 137 |
| abstract_inverted_index.Human | 82 |
| abstract_inverted_index.IL-33 | 4, 53, 72, 115, 119, 128, 138, 151, 170, 195, 211, 222 |
| abstract_inverted_index.TSLP. | 117 |
| abstract_inverted_index.acute | 50, 64, 180, 215 |
| abstract_inverted_index.after | 112 |
| abstract_inverted_index.cells | 26, 70, 85, 90, 203 |
| abstract_inverted_index.human | 244 |
| abstract_inverted_index.major | 31 |
| abstract_inverted_index.novel | 238 |
| abstract_inverted_index.plays | 171 |
| abstract_inverted_index.roles | 16, 173 |
| abstract_inverted_index.their | 15 |
| abstract_inverted_index.which | 36, 178 |
| abstract_inverted_index.while | 130 |
| abstract_inverted_index.FcεRI | 164 |
| abstract_inverted_index.IL-33, | 34 |
| abstract_inverted_index.Thymic | 6 |
| abstract_inverted_index.and/or | 116 |
| abstract_inverted_index.cells, | 176 |
| abstract_inverted_index.cells. | 56 |
| abstract_inverted_index.during | 223 |
| abstract_inverted_index.effect | 156, 232 |
| abstract_inverted_index.levels | 107, 134 |
| abstract_inverted_index.study, | 60 |
| abstract_inverted_index.study. | 102 |
| abstract_inverted_index.(TSLP), | 9 |
| abstract_inverted_index.affects | 75 |
| abstract_inverted_index.alarmin | 210 |
| abstract_inverted_index.asthma. | 24 |
| abstract_inverted_index.because | 13 |
| abstract_inverted_index.chronic | 18 |
| abstract_inverted_index.current | 59 |
| abstract_inverted_index.effects | 51, 181 |
| abstract_inverted_index.include | 182 |
| abstract_inverted_index.induced | 120 |
| abstract_inverted_index.pathway | 240 |
| abstract_inverted_index.quickly | 205 |
| abstract_inverted_index.reduced | 132 |
| abstract_inverted_index.reduces | 196, 226 |
| abstract_inverted_index.release | 122, 184 |
| abstract_inverted_index.respond | 38 |
| abstract_inverted_index.stromal | 7 |
| abstract_inverted_index.studies | 43 |
| abstract_inverted_index.targets | 32 |
| abstract_inverted_index.whereas | 191, 218 |
| abstract_inverted_index.(CBMCs), | 91 |
| abstract_inverted_index.(HLMCs), | 86 |
| abstract_inverted_index.Receptor | 103 |
| abstract_inverted_index.allergic | 19 |
| abstract_inverted_index.conclude | 200 |
| abstract_inverted_index.cytokine | 183 |
| abstract_inverted_index.exposure | 67, 126, 149, 193, 220 |
| abstract_inverted_index.extended | 219 |
| abstract_inverted_index.feedback | 231 |
| abstract_inverted_index.initiate | 213 |
| abstract_inverted_index.interest | 12 |
| abstract_inverted_index.measured | 111 |
| abstract_inverted_index.mediator | 76 |
| abstract_inverted_index.negative | 230 |
| abstract_inverted_index.presence | 235 |
| abstract_inverted_index.response | 207 |
| abstract_inverted_index.strongly | 140 |
| abstract_inverted_index.suggests | 233 |
| abstract_inverted_index.Prolonged | 125 |
| abstract_inverted_index.attracted | 11 |
| abstract_inverted_index.contrast, | 145 |
| abstract_inverted_index.decreased | 152 |
| abstract_inverted_index.including | 3 |
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| abstract_inverted_index.mediators | 109 |
| abstract_inverted_index.modulates | 242 |
| abstract_inverted_index.performed | 44 |
| abstract_inverted_index.prolonged | 66, 192, 224 |
| abstract_inverted_index.reduction | 162 |
| abstract_inverted_index.response, | 217 |
| abstract_inverted_index.secreting | 40 |
| abstract_inverted_index.synthesis | 77 |
| abstract_inverted_index.treatment | 113, 139 |
| abstract_inverted_index.tryptase. | 136 |
| abstract_inverted_index.Epithelial | 1 |
| abstract_inverted_index.conditions | 21 |
| abstract_inverted_index.cytokines, | 2 |
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| abstract_inverted_index.regulatory | 239 |
| abstract_inverted_index.responses. | 228, 247 |
| abstract_inverted_index.accompanied | 159 |
| abstract_inverted_index.activation, | 154 |
| abstract_inverted_index.activation. | 80, 143, 198 |
| abstract_inverted_index.expression. | 165 |
| abstract_inverted_index.potentiated | 141 |
| abstract_inverted_index.IgE-mediated | 79, 142, 153, 189, 197, 227, 243 |
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| abstract_inverted_index.investigated | 48, 62 |
| abstract_inverted_index.potentiation | 187 |
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| abstract_inverted_index.intracellular | 133 |
| abstract_inverted_index.lymphopoietin | 8 |
| abstract_inverted_index.degranulation, | 190 |
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| abstract_inverted_index.<b>Results:</b> | 118 |
| abstract_inverted_index.<b>Background:</b> | 0 |
| abstract_inverted_index.<b>Conclusion:</b> | 166 |
| abstract_inverted_index.inflammation-related | 20 |
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| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5016859188 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I123387679, https://openalex.org/I1335113835, https://openalex.org/I28166907 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.87475208 |
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| citation_normalized_percentile.is_in_top_10_percent | True |