Diversity of 3’ Variable Region of cagA Gene in Helicobacter Pylori Strains Isolated from Chinese Population Article Swipe
Zhijing Xue
,
Yuanhai You
,
Lihua He
,
Yanan Gong
,
Lu Sun
,
Xiurui Han
,
Ruyue Fan
,
Kangle Zhai
,
Yaming Yang
,
Jianzhong Zhang
,
Xiaomei Yan
,
Jianzhong Zhang
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-127429/v1
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-127429/v1
Background: CagA is one of the most important virulence factors of Helicobacter pylori (H. pylori). There is a highly polymorphic Glu-Pro-Ile-Tyr-Ala (EPIYA) repeat region in the CagA 3’ variable region. This repeat region is thought to play an important role in the pathogenesis of gastrointestinal diseases. The aim of this study was to investigate the diversity of CagA 3’ variable region and the amino acid polymorphisms in the EPIYA segments, and their association with gastroduodenal diseases.Methods: A total of 515 H. pylori isolates from patients in 14 different geographical regions of China were collected and the genomic DNA was extracted. The 3’ variable region of the cagA was amplified by polymerase chain reaction (PCR) and then followed by DNA sequencing, and the amino acid sequences were analyzed with MEGA 7.0 software.Results: A total of 503 (97.7%) H. pylori isolates were cagA-positive and 1,587 EPIYA motifs were obtained, including 12 types of EPIYA or EPIYA-like sequences. In addition to the four reported major segments, several rare segments (e.g., B’, B’’ and D’) were defined and 20 different sequence types (e.g., ABD, ABC) were found in our study. A total of 481 (95.6%) strains were East Asian type, most of them were ABD subtype (82.1%). Only 22 strains were Western type, including types AC, ABC, ABCC and ABCCCC. The CagA-ABD subtype had statistical difference in different geographic regions (P=0.006). There are seven amino acid polymorphisms in the sequences surrounding the EPIYA motifs, among which amino acid residue 893 and 894 had a statistical difference with gastric cancer (P=0.004).Conclusions: In this study, 503 CagA sequences was studied and analyzed in depth. In Chinese population, most H. pylori isolates are of the CagA-ABD subtype and its presence was associated with gastroduodenal disease. Amino acid polymorphisms at residue 893 and 894 flanking the EPIYA motif had a statistically significant association with gastric cancer.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-127429/v1
- https://www.researchsquare.com/article/rs-127429/v1.pdf?c=1631881934000
- OA Status
- gold
- Cited By
- 1
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4247257350
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- OpenAlex ID
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https://openalex.org/W4247257350Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-127429/v1Digital Object Identifier
- Title
-
Diversity of 3’ Variable Region of cagA Gene in Helicobacter Pylori Strains Isolated from Chinese PopulationWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-16Full publication date if available
- Authors
-
Zhijing Xue, Yuanhai You, Lihua He, Yanan Gong, Lu Sun, Xiurui Han, Ruyue Fan, Kangle Zhai, Yaming Yang, Jianzhong Zhang, Xiaomei Yan, Jianzhong ZhangList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-127429/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-127429/v1.pdf?c=1631881934000Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-127429/v1.pdf?c=1631881934000Direct OA link when available
- Concepts
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CagA, Helicobacter pylori, Diversity (politics), Genetics, Gene, Biology, Population, Genetic diversity, Microbiology, Medicine, Political science, Virulence, Environmental health, LawTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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18Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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