DNA Methylation and Intra-Clonal Heterogeneity: The Chronic Myeloid Leukemia Model Article Swipe
Benjamin Lebecque
,
Céline Bourgne
,
Véronique Vidal
,
Marc Berger
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/cancers13143587
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/cancers13143587
Chronic Myeloid Leukemia (CML) is a model to investigate the impact of tumor intra-clonal heterogeneity in personalized medicine. Indeed, tyrosine kinase inhibitors (TKIs) target the BCR-ABL fusion protein, which is considered the major CML driver. TKI use has highlighted the existence of intra-clonal heterogeneity, as indicated by the persistence of a minority subclone for several years despite the presence of the target fusion protein in all cells. Epigenetic modifications could partly explain this heterogeneity. This review summarizes the results of DNA methylation studies in CML. Next-generation sequencing technologies allowed for moving from single-gene to genome-wide analyses showing that methylation abnormalities are much more widespread in CML cells. These data showed that global hypomethylation is associated with hypermethylation of specific sites already at diagnosis in the early phase of CML. The BCR-ABL-independence of some methylation profile alterations and the recent demonstration of the initial intra-clonal DNA methylation heterogeneity suggests that some DNA methylation alterations may be biomarkers of TKI sensitivity/resistance and of disease progression risk. These results also open perspectives for understanding the epigenetic/genetic background of CML predisposition and for developing new therapeutic strategies.
Related Topics
Concepts
DNA methylation
Epigenetics
Myeloid leukemia
Biology
Methylation
Genetic heterogeneity
Somatic evolution in cancer
Cancer research
Genetics
Fusion gene
ABL
Gene
Tyrosine kinase
Phenotype
Signal transduction
Gene expression
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers13143587
- https://www.mdpi.com/2072-6694/13/14/3587/pdf?version=1626508443
- OA Status
- gold
- Cited By
- 12
- References
- 134
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3186463542
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3186463542Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers13143587Digital Object Identifier
- Title
-
DNA Methylation and Intra-Clonal Heterogeneity: The Chronic Myeloid Leukemia ModelWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-17Full publication date if available
- Authors
-
Benjamin Lebecque, Céline Bourgne, Véronique Vidal, Marc BergerList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers13143587Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6694/13/14/3587/pdf?version=1626508443Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2072-6694/13/14/3587/pdf?version=1626508443Direct OA link when available
- Concepts
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DNA methylation, Epigenetics, Myeloid leukemia, Biology, Methylation, Genetic heterogeneity, Somatic evolution in cancer, Cancer research, Genetics, Fusion gene, ABL, Gene, Tyrosine kinase, Phenotype, Signal transduction, Gene expressionTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 4, 2022: 6, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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134Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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