Do the Choice of Fusion Construct With and Without Autograft Influence the Fusion and Complication Rates in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery? A PRISMA-Compliant Network Meta-Analysis Article Swipe
Sathish Muthu
,
Vibhu Krishnan Viswanathan
,
Ricardo Rodrigues‐Pinto
,
Juan P. Cabrera
,
Stipe Ćorluka
,
Christopher T. Martin
,
Michael J. Collins
,
Neha Agarwal
,
Yabin Wu
,
Jeffrey C. Wang
,
Hans-Joerg Meisel
,
Zorica Buser
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/21925682231154488
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/21925682231154488
Study Design Network meta-analysis. Objectives To compare the fusion outcome and complications of different 1 or 2-level anterior cervical decompression and fusion (ACDF) constructs performed with and without the application of autografts. Methods We performed an independent and duplicate search in electronic databases including PubMed, Embase, Web of Science, Cochrane, and Scopus for relevant articles published between 2000 and 2020. We included comparative studies reporting fusion rate and complications with and without the use of autografts in ACDF across 5 different fusion constructs. A network meta-analysis was performed in Stata, categorized based on the type of fusion constructs utilized. Fusion constructs were ranked based on p-score approach and surface under cumulative ranking curve (SUCRA) scores. The confidence of results from the analysis was appraised with Cochrane’s CINeMA approach. Results A total of 2216 patients from 22-studies including 6 Randomized Controlled Trials (RCTs) and 16 non-RCTs were included in network analysis. The mean age of included patients was 49.3 (±3.62) years. Based on our meta-analysis, we could conclude that use of autograft in 1- or 2-level ACDF did not affect the fusion and mechanical implant-related complications. The final fusion and mechanical complication rates were also not significantly different across the different fusion constructs. The use of plated constructs was associated with a significant increase in post-ACDF dysphagia rates [OR 3.42; 95%CI (.01,2.45)], as compared to stand-alone constructs analysed. Conclusion The choice of fusion constructs and use of autografts does not significantly affect the fusion and overall complication rates following 1 or 2-level ACDF surgery.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/21925682231154488
- OA Status
- gold
- Cited By
- 2
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4318755356
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4318755356Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/21925682231154488Digital Object Identifier
- Title
-
Do the Choice of Fusion Construct With and Without Autograft Influence the Fusion and Complication Rates in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery? A PRISMA-Compliant Network Meta-AnalysisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-02-01Full publication date if available
- Authors
-
Sathish Muthu, Vibhu Krishnan Viswanathan, Ricardo Rodrigues‐Pinto, Juan P. Cabrera, Stipe Ćorluka, Christopher T. Martin, Michael J. Collins, Neha Agarwal, Yabin Wu, Jeffrey C. Wang, Hans-Joerg Meisel, Zorica BuserList of authors in order
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https://doi.org/10.1177/21925682231154488Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1177/21925682231154488Direct OA link when available
- Concepts
-
Medicine, Anterior cervical discectomy and fusion, Surgery, Complication, Fusion, Spinal fusion, Cervical spine, Philosophy, LinguisticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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