DOCK2 protects against bacterial sepsis by constraining T helper 1 response Article Swipe
Shusen Ye
,
Linzi Huang
,
Yuhao Zheng
,
Shanshan Liu
,
Xiangyang Wang
,
Haoyuan Yu
,
Lisi Zhu
,
Ting Liang
,
Yifei Wang
,
Chunmin Zhang
,
Fan Wu
,
Lilin Ye
,
Yingjiao Cao
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2025.1527934
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2025.1527934
Background Sepsis is a systemic host response to infection with life-threatening consequence which ranks among the top ten causes of death worldwide. Nevertheless, our understanding of the molecular and cellular impact of sepsis remains rudimentary. Methods A mouse sepsis model was established through LPS induction and Escherichia coli ( E. coli ) infection. Flow cytometry and enzyme-linked immunosorbent assay (ELISA) were used to detect T helper 1 (Th1) cell subsets and serum pro-inflammatory cytokines in septic mice. Additionally, in vivo neutralization experiments were conducted to block IFN-γ and CD4+ T cells, respectively, to explore the regulatory effect of DOCK2 on septic mice. Finally, the regulatory mechanism of DOCK2 was analyzed using an in vivo RNA-seq system. Results We identified dedicator of cytokinesis 2 (DOCK2) is a critical downregulating factor for LPS signal pathways. DOCK2-deficient mice were highly sensitive to LPS-induced sepsis and E. coli sepsis with increased levels of inflammatory cytokines, especially IFN-γ which were mainly due to hyperresponsive Th1 cells. Ulteriorly, we verified the vital role of DOCK2-mediated Th1 cells in sepsis by neutralizing both IFN-γ and CD4 and found both of which blockade reduced the severity of sepsis in Dock2 −/− mice. Mechanically, DOCK2-mediated cell cycle progression and cytokine signaling act in concert to govern peripheral Th1 cell fate. Conclusion Our data indicates that DOCK2 acts as a protective role in regulating systemic inflammation and multi-organ injury in bacterial sepsis by constraining Th1 response. These findings provide new targets for immunomodulatory therapy of sepsis, suggesting that targeting the DOCK2-Th1 axis may become a new strategy to improve systemic inflammatory responses associated with bacterial infections.
Related Topics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2025.1527934
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1527934/pdf
- OA Status
- gold
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410872747
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4410872747Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2025.1527934Digital Object Identifier
- Title
-
DOCK2 protects against bacterial sepsis by constraining T helper 1 responseWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-29Full publication date if available
- Authors
-
Shusen Ye, Linzi Huang, Yuhao Zheng, Shanshan Liu, Xiangyang Wang, Haoyuan Yu, Lisi Zhu, Ting Liang, Yifei Wang, Chunmin Zhang, Fan Wu, Lilin Ye, Yingjiao CaoList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2025.1527934Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1527934/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1527934/pdfDirect OA link when available
- Concepts
-
Sepsis, Immunology, Inflammatory response, Medicine, Microbiology, Biology, InflammationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
38Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4410872747 |
|---|---|
| doi | https://doi.org/10.3389/fimmu.2025.1527934 |
| ids.doi | https://doi.org/10.3389/fimmu.2025.1527934 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40510337 |
| ids.openalex | https://openalex.org/W4410872747 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000276 |
| mesh[1].descriptor_ui | D018805 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | immunology |
| mesh[1].descriptor_name | Sepsis |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D018805 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Sepsis |
| mesh[3].qualifier_ui | Q000382 |
| mesh[3].descriptor_ui | D018805 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | microbiology |
| mesh[3].descriptor_name | Sepsis |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D051379 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Mice |
| mesh[5].qualifier_ui | Q000276 |
| mesh[5].descriptor_ui | D018417 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | immunology |
| mesh[5].descriptor_name | Th1 Cells |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D018417 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Th1 Cells |
| mesh[7].qualifier_ui | Q000276 |
| mesh[7].descriptor_ui | D004927 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | immunology |
| mesh[7].descriptor_name | Escherichia coli Infections |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D020690 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | GTPase-Activating Proteins |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D020690 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | GTPase-Activating Proteins |
| mesh[10].qualifier_ui | Q000276 |
| mesh[10].descriptor_ui | D020690 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | immunology |
| mesh[10].descriptor_name | GTPase-Activating Proteins |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008070 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Lipopolysaccharides |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D018345 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Mice, Knockout |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D004195 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Disease Models, Animal |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D008810 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Mice, Inbred C57BL |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D016207 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Cytokines |
| mesh[16].qualifier_ui | Q000276 |
| mesh[16].descriptor_ui | D004926 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | immunology |
| mesh[16].descriptor_name | Escherichia coli |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D007371 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Interferon-gamma |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D015398 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Signal Transduction |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D020662 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Guanine Nucleotide Exchange Factors |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D000818 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Animals |
| mesh[21].qualifier_ui | Q000276 |
| mesh[21].descriptor_ui | D018805 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | immunology |
| mesh[21].descriptor_name | Sepsis |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D018805 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Sepsis |
| mesh[23].qualifier_ui | Q000382 |
| mesh[23].descriptor_ui | D018805 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | microbiology |
| mesh[23].descriptor_name | Sepsis |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D051379 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Mice |
| mesh[25].qualifier_ui | Q000276 |
| mesh[25].descriptor_ui | D018417 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | immunology |
| mesh[25].descriptor_name | Th1 Cells |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D018417 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Th1 Cells |
| mesh[27].qualifier_ui | Q000276 |
| mesh[27].descriptor_ui | D004927 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | immunology |
| mesh[27].descriptor_name | Escherichia coli Infections |
| mesh[28].qualifier_ui | Q000235 |
| mesh[28].descriptor_ui | D020690 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | genetics |
| mesh[28].descriptor_name | GTPase-Activating Proteins |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D020690 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | GTPase-Activating Proteins |
| mesh[30].qualifier_ui | Q000276 |
| mesh[30].descriptor_ui | D020690 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | immunology |
| mesh[30].descriptor_name | GTPase-Activating Proteins |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D008070 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Lipopolysaccharides |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D018345 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Mice, Knockout |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D004195 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Disease Models, Animal |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D008810 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Mice, Inbred C57BL |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D016207 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | Cytokines |
| mesh[36].qualifier_ui | Q000276 |
| mesh[36].descriptor_ui | D004926 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | immunology |
| mesh[36].descriptor_name | Escherichia coli |
| mesh[37].qualifier_ui | Q000378 |
| mesh[37].descriptor_ui | D007371 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | metabolism |
| mesh[37].descriptor_name | Interferon-gamma |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D015398 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Signal Transduction |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D020662 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Guanine Nucleotide Exchange Factors |
| type | article |
| title | DOCK2 protects against bacterial sepsis by constraining T helper 1 response |
| biblio.issue | |
| biblio.volume | 16 |
| biblio.last_page | 1527934 |
| biblio.first_page | 1527934 |
| topics[0].id | https://openalex.org/T10371 |
| topics[0].field.id | https://openalex.org/fields/24 |
| topics[0].field.display_name | Immunology and Microbiology |
| topics[0].score | 0.9948999881744385 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2403 |
| topics[0].subfield.display_name | Immunology |
| topics[0].display_name | Immune Response and Inflammation |
| topics[1].id | https://openalex.org/T12620 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9882000088691711 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Signaling Pathways in Disease |
| topics[2].id | https://openalex.org/T10038 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9846000075340271 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2725 |
| topics[2].subfield.display_name | Infectious Diseases |
| topics[2].display_name | Tuberculosis Research and Epidemiology |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C2778384902 |
| concepts[0].level | 2 |
| concepts[0].score | 0.5983350872993469 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q183134 |
| concepts[0].display_name | Sepsis |
| concepts[1].id | https://openalex.org/C203014093 |
| concepts[1].level | 1 |
| concepts[1].score | 0.5129141807556152 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[1].display_name | Immunology |
| concepts[2].id | https://openalex.org/C3020196126 |
| concepts[2].level | 3 |
| concepts[2].score | 0.45934468507766724 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[2].display_name | Inflammatory response |
| concepts[3].id | https://openalex.org/C71924100 |
| concepts[3].level | 0 |
| concepts[3].score | 0.45592594146728516 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[3].display_name | Medicine |
| concepts[4].id | https://openalex.org/C89423630 |
| concepts[4].level | 1 |
| concepts[4].score | 0.3249531686306 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7193 |
| concepts[4].display_name | Microbiology |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.31593096256256104 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C2776914184 |
| concepts[6].level | 2 |
| concepts[6].score | 0.1994902491569519 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[6].display_name | Inflammation |
| keywords[0].id | https://openalex.org/keywords/sepsis |
| keywords[0].score | 0.5983350872993469 |
| keywords[0].display_name | Sepsis |
| keywords[1].id | https://openalex.org/keywords/immunology |
| keywords[1].score | 0.5129141807556152 |
| keywords[1].display_name | Immunology |
| keywords[2].id | https://openalex.org/keywords/inflammatory-response |
| keywords[2].score | 0.45934468507766724 |
| keywords[2].display_name | Inflammatory response |
| keywords[3].id | https://openalex.org/keywords/medicine |
| keywords[3].score | 0.45592594146728516 |
| keywords[3].display_name | Medicine |
| keywords[4].id | https://openalex.org/keywords/microbiology |
| keywords[4].score | 0.3249531686306 |
| keywords[4].display_name | Microbiology |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.31593096256256104 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/inflammation |
| keywords[6].score | 0.1994902491569519 |
| keywords[6].display_name | Inflammation |
| language | en |
| locations[0].id | doi:10.3389/fimmu.2025.1527934 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2595292759 |
| locations[0].source.issn | 1664-3224 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-3224 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Immunology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1527934/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Immunology |
| locations[0].landing_page_url | https://doi.org/10.3389/fimmu.2025.1527934 |
| locations[1].id | pmid:40510337 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in immunology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40510337 |
| locations[2].id | pmh:oai:doaj.org/article:908b92da75564740b0acf4a5d79ac84c |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in Immunology, Vol 16 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/908b92da75564740b0acf4a5d79ac84c |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5022594823 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-4518-0781 |
| authorships[0].author.display_name | Shusen Ye |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute of Immunological Innovation and Translation, Institute of Life Sciences, Chongqing Medical University, Chongqing, China. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I58200834 |
| authorships[0].affiliations[1].raw_affiliation_string | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[0].institutions[0].id | https://openalex.org/I87780372 |
| authorships[0].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Chongqing Medical University |
| authorships[0].institutions[1].id | https://openalex.org/I58200834 |
| authorships[0].institutions[1].ror | https://ror.org/01vjw4z39 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I58200834 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Southern Medical University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Shusen Ye |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China., Institute of Immunological Innovation and Translation, Institute of Life Sciences, Chongqing Medical University, Chongqing, China. |
| authorships[1].author.id | https://openalex.org/A5102557749 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Linzi Huang |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I58200834 |
| authorships[1].affiliations[0].raw_affiliation_string | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[1].institutions[0].id | https://openalex.org/I58200834 |
| authorships[1].institutions[0].ror | https://ror.org/01vjw4z39 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I58200834 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Southern Medical University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Linzi Huang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[2].author.id | https://openalex.org/A5102802347 |
| authorships[2].author.orcid | https://orcid.org/0009-0008-1216-1684 |
| authorships[2].author.display_name | Yuhao Zheng |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I58200834 |
| authorships[2].affiliations[0].raw_affiliation_string | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[2].institutions[0].id | https://openalex.org/I58200834 |
| authorships[2].institutions[0].ror | https://ror.org/01vjw4z39 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I58200834 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Southern Medical University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yuhao Zheng |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[3].author.id | https://openalex.org/A5100417155 |
| authorships[3].author.orcid | https://orcid.org/0009-0007-0775-5616 |
| authorships[3].author.display_name | Shanshan Liu |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I58200834 |
| authorships[3].affiliations[0].raw_affiliation_string | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[3].institutions[0].id | https://openalex.org/I58200834 |
| authorships[3].institutions[0].ror | https://ror.org/01vjw4z39 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I58200834 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Southern Medical University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Shanshan Liu |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[4].author.id | https://openalex.org/A5100755826 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-2276-539X |
| authorships[4].author.display_name | Xiangyang Wang |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210145693, https://openalex.org/I4210153930 |
| authorships[4].affiliations[0].raw_affiliation_string | Guangdong Cardiovascular Institute, Guangdong, Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. |
| authorships[4].institutions[0].id | https://openalex.org/I4210145693 |
| authorships[4].institutions[0].ror | https://ror.org/0432p8t34 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210145693 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Guangdong Academy of Medical Sciences |
| authorships[4].institutions[1].id | https://openalex.org/I4210153930 |
| authorships[4].institutions[1].ror | https://ror.org/045kpgw45 |
| authorships[4].institutions[1].type | healthcare |
| authorships[4].institutions[1].lineage | https://openalex.org/I4210153930 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | Guangdong Provincial People's Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Xiangyang Wang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Guangdong Cardiovascular Institute, Guangdong, Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. |
| authorships[5].author.id | https://openalex.org/A5074913912 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-5873-3715 |
| authorships[5].author.display_name | Haoyuan Yu |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I157773358, https://openalex.org/I4210146956 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. |
| authorships[5].affiliations[1].raw_affiliation_string | Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China. |
| authorships[5].institutions[0].id | https://openalex.org/I157773358 |
| authorships[5].institutions[0].ror | https://ror.org/0064kty71 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I157773358 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Sun Yat-sen University |
| authorships[5].institutions[1].id | https://openalex.org/I4210146956 |
| authorships[5].institutions[1].ror | https://ror.org/04tm3k558 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I4210146956 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | Third Affiliated Hospital of Sun Yat-sen University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Haoyuan Yu |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China. |
| authorships[6].author.id | https://openalex.org/A5024441209 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Lisi Zhu |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I58200834 |
| authorships[6].affiliations[0].raw_affiliation_string | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[6].institutions[0].id | https://openalex.org/I58200834 |
| authorships[6].institutions[0].ror | https://ror.org/01vjw4z39 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I58200834 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Southern Medical University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Lisi Zhu |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[7].author.id | https://openalex.org/A5001118139 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4121-0787 |
| authorships[7].author.display_name | Ting Liang |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I58200834 |
| authorships[7].affiliations[0].raw_affiliation_string | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[7].institutions[0].id | https://openalex.org/I58200834 |
| authorships[7].institutions[0].ror | https://ror.org/01vjw4z39 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I58200834 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Southern Medical University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Texi Liang |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[8].author.id | https://openalex.org/A5100365600 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-9918-2865 |
| authorships[8].author.display_name | Yifei Wang |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I87780372 |
| authorships[8].affiliations[0].raw_affiliation_string | Institute of Immunological Innovation and Translation, Institute of Life Sciences, Chongqing Medical University, Chongqing, China. |
| authorships[8].institutions[0].id | https://openalex.org/I87780372 |
| authorships[8].institutions[0].ror | https://ror.org/017z00e58 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I87780372 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Chongqing Medical University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Yifei Wang |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Institute of Immunological Innovation and Translation, Institute of Life Sciences, Chongqing Medical University, Chongqing, China. |
| authorships[9].author.id | https://openalex.org/A5071980364 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-4624-6818 |
| authorships[9].author.display_name | Chunmin Zhang |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I92039509 |
| authorships[9].affiliations[0].raw_affiliation_string | Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. |
| authorships[9].institutions[0].id | https://openalex.org/I92039509 |
| authorships[9].institutions[0].ror | https://ror.org/00zat6v61 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I92039509 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Guangzhou Medical University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Chunmin Zhang |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. |
| authorships[10].author.id | https://openalex.org/A5101428140 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-5750-7775 |
| authorships[10].author.display_name | Fan Wu |
| authorships[10].countries | CN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4210092091, https://openalex.org/I92039509 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. |
| authorships[10].institutions[0].id | https://openalex.org/I92039509 |
| authorships[10].institutions[0].ror | https://ror.org/00zat6v61 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I92039509 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Guangzhou Medical University |
| authorships[10].institutions[1].id | https://openalex.org/I4210092091 |
| authorships[10].institutions[1].ror | https://ror.org/00fb35g87 |
| authorships[10].institutions[1].type | healthcare |
| authorships[10].institutions[1].lineage | https://openalex.org/I4210092091 |
| authorships[10].institutions[1].country_code | CN |
| authorships[10].institutions[1].display_name | Third Affiliated Hospital of Guangzhou Medical University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Fan Wu |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. |
| authorships[11].author.id | https://openalex.org/A5064212776 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-0778-3311 |
| authorships[11].author.display_name | Lilin Ye |
| authorships[11].countries | CN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I151075929 |
| authorships[11].affiliations[0].raw_affiliation_string | Institute of Immunology, Third Military Medical University, Chongqing, China. |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I58200834 |
| authorships[11].affiliations[1].raw_affiliation_string | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[11].institutions[0].id | https://openalex.org/I151075929 |
| authorships[11].institutions[0].ror | https://ror.org/05w21nn13 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I151075929 |
| authorships[11].institutions[0].country_code | CN |
| authorships[11].institutions[0].display_name | Army Medical University |
| authorships[11].institutions[1].id | https://openalex.org/I58200834 |
| authorships[11].institutions[1].ror | https://ror.org/01vjw4z39 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I58200834 |
| authorships[11].institutions[1].country_code | CN |
| authorships[11].institutions[1].display_name | Southern Medical University |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Lilin Ye |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China., Institute of Immunology, Third Military Medical University, Chongqing, China. |
| authorships[12].author.id | https://openalex.org/A5103132739 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-1689-0397 |
| authorships[12].author.display_name | Yingjiao Cao |
| authorships[12].countries | CN |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I58200834 |
| authorships[12].affiliations[0].raw_affiliation_string | Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I157773358 |
| authorships[12].affiliations[1].raw_affiliation_string | Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. |
| authorships[12].institutions[0].id | https://openalex.org/I58200834 |
| authorships[12].institutions[0].ror | https://ror.org/01vjw4z39 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I58200834 |
| authorships[12].institutions[0].country_code | CN |
| authorships[12].institutions[0].display_name | Southern Medical University |
| authorships[12].institutions[1].id | https://openalex.org/I157773358 |
| authorships[12].institutions[1].ror | https://ror.org/0064kty71 |
| authorships[12].institutions[1].type | education |
| authorships[12].institutions[1].lineage | https://openalex.org/I157773358 |
| authorships[12].institutions[1].country_code | CN |
| authorships[12].institutions[1].display_name | Sun Yat-sen University |
| authorships[12].author_position | last |
| authorships[12].raw_author_name | Yingjiao Cao |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1527934/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | DOCK2 protects against bacterial sepsis by constraining T helper 1 response |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10371 |
| primary_topic.field.id | https://openalex.org/fields/24 |
| primary_topic.field.display_name | Immunology and Microbiology |
| primary_topic.score | 0.9948999881744385 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2403 |
| primary_topic.subfield.display_name | Immunology |
| primary_topic.display_name | Immune Response and Inflammation |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2082860237, https://openalex.org/W2119695867, https://openalex.org/W2130076355, https://openalex.org/W1990804418, https://openalex.org/W1993764875, https://openalex.org/W2046158694, https://openalex.org/W2788277189, https://openalex.org/W2013243191, https://openalex.org/W2034930488 |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.3389/fimmu.2025.1527934 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2595292759 |
| best_oa_location.source.issn | 1664-3224 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-3224 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Immunology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1527934/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Immunology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fimmu.2025.1527934 |
| primary_location.id | doi:10.3389/fimmu.2025.1527934 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2595292759 |
| primary_location.source.issn | 1664-3224 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-3224 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Immunology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1527934/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Immunology |
| primary_location.landing_page_url | https://doi.org/10.3389/fimmu.2025.1527934 |
| publication_date | 2025-05-29 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2164990391, https://openalex.org/W2276440020, https://openalex.org/W2280404143, https://openalex.org/W2116965731, https://openalex.org/W2998853022, https://openalex.org/W2069477224, https://openalex.org/W1541752202, https://openalex.org/W2527025443, https://openalex.org/W2134271951, https://openalex.org/W2022157262, https://openalex.org/W2075647074, https://openalex.org/W2770579713, https://openalex.org/W2157781322, https://openalex.org/W2153070402, https://openalex.org/W2068767807, https://openalex.org/W2169456326, https://openalex.org/W1999574084, https://openalex.org/W2179438025, https://openalex.org/W2035618305, https://openalex.org/W2130410032, https://openalex.org/W2980389928, https://openalex.org/W2898830231, https://openalex.org/W4392156325, https://openalex.org/W1975349772, https://openalex.org/W2171414837, https://openalex.org/W1964843611, https://openalex.org/W4388969278, https://openalex.org/W2062267397, https://openalex.org/W4396544943, https://openalex.org/W3005906476, https://openalex.org/W2002548381, https://openalex.org/W4388233540, https://openalex.org/W4392377244, https://openalex.org/W2979460593, https://openalex.org/W4384938281, https://openalex.org/W3114359894, https://openalex.org/W2918557667, https://openalex.org/W1998047654 |
| referenced_works_count | 38 |
| abstract_inverted_index.( | 48 |
| abstract_inverted_index.) | 51 |
| abstract_inverted_index.1 | 66 |
| abstract_inverted_index.2 | 122 |
| abstract_inverted_index.A | 36 |
| abstract_inverted_index.T | 64, 89 |
| abstract_inverted_index.a | 3, 125, 219, 254 |
| abstract_inverted_index.E. | 49, 142 |
| abstract_inverted_index.We | 117 |
| abstract_inverted_index.an | 111 |
| abstract_inverted_index.as | 218 |
| abstract_inverted_index.by | 173, 232 |
| abstract_inverted_index.in | 74, 78, 112, 171, 190, 203, 222, 229 |
| abstract_inverted_index.is | 2, 124 |
| abstract_inverted_index.of | 19, 25, 31, 97, 106, 120, 148, 167, 182, 188, 244 |
| abstract_inverted_index.on | 99 |
| abstract_inverted_index.to | 7, 62, 84, 92, 138, 157, 205, 257 |
| abstract_inverted_index.we | 162 |
| abstract_inverted_index.CD4 | 178 |
| abstract_inverted_index.LPS | 43, 130 |
| abstract_inverted_index.Our | 212 |
| abstract_inverted_index.Th1 | 159, 169, 208, 234 |
| abstract_inverted_index.act | 202 |
| abstract_inverted_index.and | 28, 45, 55, 70, 87, 141, 177, 179, 199, 226 |
| abstract_inverted_index.due | 156 |
| abstract_inverted_index.for | 129, 241 |
| abstract_inverted_index.may | 252 |
| abstract_inverted_index.new | 239, 255 |
| abstract_inverted_index.our | 23 |
| abstract_inverted_index.ten | 17 |
| abstract_inverted_index.the | 15, 26, 94, 103, 164, 186, 249 |
| abstract_inverted_index.top | 16 |
| abstract_inverted_index.was | 40, 108 |
| abstract_inverted_index.CD4+ | 88 |
| abstract_inverted_index.Flow | 53 |
| abstract_inverted_index.acts | 217 |
| abstract_inverted_index.axis | 251 |
| abstract_inverted_index.both | 175, 181 |
| abstract_inverted_index.cell | 68, 196, 209 |
| abstract_inverted_index.coli | 47, 50, 143 |
| abstract_inverted_index.data | 213 |
| abstract_inverted_index.host | 5 |
| abstract_inverted_index.mice | 134 |
| abstract_inverted_index.role | 166, 221 |
| abstract_inverted_index.that | 215, 247 |
| abstract_inverted_index.used | 61 |
| abstract_inverted_index.vivo | 79, 113 |
| abstract_inverted_index.were | 60, 82, 135, 154 |
| abstract_inverted_index.with | 9, 145, 263 |
| abstract_inverted_index.(Th1) | 67 |
| abstract_inverted_index.DOCK2 | 98, 107, 216 |
| abstract_inverted_index.Dock2 | 191 |
| abstract_inverted_index.These | 236 |
| abstract_inverted_index.among | 14 |
| abstract_inverted_index.assay | 58 |
| abstract_inverted_index.block | 85 |
| abstract_inverted_index.cells | 170 |
| abstract_inverted_index.cycle | 197 |
| abstract_inverted_index.death | 20 |
| abstract_inverted_index.fate. | 210 |
| abstract_inverted_index.found | 180 |
| abstract_inverted_index.mice. | 76, 101, 193 |
| abstract_inverted_index.model | 39 |
| abstract_inverted_index.mouse | 37 |
| abstract_inverted_index.ranks | 13 |
| abstract_inverted_index.serum | 71 |
| abstract_inverted_index.using | 110 |
| abstract_inverted_index.vital | 165 |
| abstract_inverted_index.which | 12, 153, 183 |
| abstract_inverted_index.IFN-γ | 86, 152, 176 |
| abstract_inverted_index.Sepsis | 1 |
| abstract_inverted_index.become | 253 |
| abstract_inverted_index.causes | 18 |
| abstract_inverted_index.cells, | 90 |
| abstract_inverted_index.cells. | 160 |
| abstract_inverted_index.detect | 63 |
| abstract_inverted_index.effect | 96 |
| abstract_inverted_index.factor | 128 |
| abstract_inverted_index.govern | 206 |
| abstract_inverted_index.helper | 65 |
| abstract_inverted_index.highly | 136 |
| abstract_inverted_index.impact | 30 |
| abstract_inverted_index.injury | 228 |
| abstract_inverted_index.levels | 147 |
| abstract_inverted_index.mainly | 155 |
| abstract_inverted_index.sepsis | 32, 38, 140, 144, 172, 189, 231 |
| abstract_inverted_index.septic | 75, 100 |
| abstract_inverted_index.signal | 131 |
| abstract_inverted_index.(DOCK2) | 123 |
| abstract_inverted_index.(ELISA) | 59 |
| abstract_inverted_index.Methods | 35 |
| abstract_inverted_index.RNA-seq | 114 |
| abstract_inverted_index.Results | 116 |
| abstract_inverted_index.concert | 204 |
| abstract_inverted_index.explore | 93 |
| abstract_inverted_index.improve | 258 |
| abstract_inverted_index.provide | 238 |
| abstract_inverted_index.reduced | 185 |
| abstract_inverted_index.remains | 33 |
| abstract_inverted_index.sepsis, | 245 |
| abstract_inverted_index.subsets | 69 |
| abstract_inverted_index.system. | 115 |
| abstract_inverted_index.targets | 240 |
| abstract_inverted_index.therapy | 243 |
| abstract_inverted_index.through | 42 |
| abstract_inverted_index.−/− | 192 |
| abstract_inverted_index.Finally, | 102 |
| abstract_inverted_index.analyzed | 109 |
| abstract_inverted_index.blockade | 184 |
| abstract_inverted_index.cellular | 29 |
| abstract_inverted_index.critical | 126 |
| abstract_inverted_index.cytokine | 200 |
| abstract_inverted_index.findings | 237 |
| abstract_inverted_index.response | 6 |
| abstract_inverted_index.severity | 187 |
| abstract_inverted_index.strategy | 256 |
| abstract_inverted_index.systemic | 4, 224, 259 |
| abstract_inverted_index.verified | 163 |
| abstract_inverted_index.DOCK2-Th1 | 250 |
| abstract_inverted_index.bacterial | 230, 264 |
| abstract_inverted_index.conducted | 83 |
| abstract_inverted_index.cytokines | 73 |
| abstract_inverted_index.cytometry | 54 |
| abstract_inverted_index.dedicator | 119 |
| abstract_inverted_index.increased | 146 |
| abstract_inverted_index.indicates | 214 |
| abstract_inverted_index.induction | 44 |
| abstract_inverted_index.infection | 8 |
| abstract_inverted_index.mechanism | 105 |
| abstract_inverted_index.molecular | 27 |
| abstract_inverted_index.pathways. | 132 |
| abstract_inverted_index.response. | 235 |
| abstract_inverted_index.responses | 261 |
| abstract_inverted_index.sensitive | 137 |
| abstract_inverted_index.signaling | 201 |
| abstract_inverted_index.targeting | 248 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Conclusion | 211 |
| abstract_inverted_index.associated | 262 |
| abstract_inverted_index.cytokines, | 150 |
| abstract_inverted_index.especially | 151 |
| abstract_inverted_index.identified | 118 |
| abstract_inverted_index.infection. | 52 |
| abstract_inverted_index.peripheral | 207 |
| abstract_inverted_index.protective | 220 |
| abstract_inverted_index.regulating | 223 |
| abstract_inverted_index.regulatory | 95, 104 |
| abstract_inverted_index.suggesting | 246 |
| abstract_inverted_index.worldwide. | 21 |
| abstract_inverted_index.Escherichia | 46 |
| abstract_inverted_index.LPS-induced | 139 |
| abstract_inverted_index.Ulteriorly, | 161 |
| abstract_inverted_index.consequence | 11 |
| abstract_inverted_index.cytokinesis | 121 |
| abstract_inverted_index.established | 41 |
| abstract_inverted_index.experiments | 81 |
| abstract_inverted_index.infections. | 265 |
| abstract_inverted_index.multi-organ | 227 |
| abstract_inverted_index.progression | 198 |
| abstract_inverted_index.constraining | 233 |
| abstract_inverted_index.inflammation | 225 |
| abstract_inverted_index.inflammatory | 149, 260 |
| abstract_inverted_index.neutralizing | 174 |
| abstract_inverted_index.rudimentary. | 34 |
| abstract_inverted_index.Additionally, | 77 |
| abstract_inverted_index.Mechanically, | 194 |
| abstract_inverted_index.Nevertheless, | 22 |
| abstract_inverted_index.enzyme-linked | 56 |
| abstract_inverted_index.immunosorbent | 57 |
| abstract_inverted_index.respectively, | 91 |
| abstract_inverted_index.understanding | 24 |
| abstract_inverted_index.DOCK2-mediated | 168, 195 |
| abstract_inverted_index.downregulating | 127 |
| abstract_inverted_index.neutralization | 80 |
| abstract_inverted_index.DOCK2-deficient | 133 |
| abstract_inverted_index.hyperresponsive | 158 |
| abstract_inverted_index.immunomodulatory | 242 |
| abstract_inverted_index.life-threatening | 10 |
| abstract_inverted_index.pro-inflammatory | 72 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.23191832 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |