Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the DINE-Normal proof-of-concept randomised parallel-group study Article Swipe
C. Beattie
,
Matt Thomas
,
Borislava Borislavova
,
Harry Smith
,
Michael Ambler
,
Paul White
,
Kati Hayes
,
Danielle Milne
,
Aravind Ramesh
,
Javier T. Gonzalez
,
James A. Betts
,
Anthony E. Pickering
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2024-086540
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2024-086540
Introduction Over half of patients who spend >48 hours in the intensive care unit (ICU) are fed via a nasogastric (NG) tube. Current guidance recommends continuous delivery of feed throughout the day and night. Emerging evidence from healthy human studies shows that NG feeding in an intermittent pattern (rather than continuous) promotes phasic hormonal, digestive and metabolic responses that are important for effective nutrition. It is not yet known whether this will translate to the critically ill population. Here, we present the protocol for a proof-of-concept study comparing diurnal intermittent vs continuous feeding on hormonal and metabolic outcomes for patients in the ICU. Methods and analysis The study is a single-centre, prospective, randomised, open-label trial comparing intermittent enteral nutrition with the current standard practice of continuous enteral feeding. It aims to recruit participants (n=30) needing enteral nutrition via an NG tube for >24 hours who will be randomised to a diurnal intermittent or a continuous feeding regimen with equivalent nutritional value. The primary outcome is peak plasma insulin/c-peptide within 3 hours of delivering the morning intermittent feed on the second study day, compared with that seen in the continuous feed delivery group at the same time point. Secondary outcomes include feasibility, tolerability, efficacy and metabolic/hormonal profiles. Ethics and dissemination We obtained ethical approval from the Wales Research Ethics Committee 3 prior to data collection (reference 23/WA/0297). We will publish the results of this study in an open-access peer-reviewed journal. Trial registration number NCT06115044 .
Related Topics
Concepts
Medicine
Parenteral nutrition
Enteral administration
Tolerability
Feeding tube
Randomized controlled trial
Population
Clinical nutrition
Clinical trial
Regimen
Protocol (science)
Intensive care medicine
Pediatrics
Internal medicine
Surgery
Alternative medicine
Adverse effect
Pathology
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmjopen-2024-086540
- OA Status
- gold
- Cited By
- 4
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404667568
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4404667568Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/bmjopen-2024-086540Digital Object Identifier
- Title
-
Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the DINE-Normal proof-of-concept randomised parallel-group studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-11-01Full publication date if available
- Authors
-
C. Beattie, Matt Thomas, Borislava Borislavova, Harry Smith, Michael Ambler, Paul White, Kati Hayes, Danielle Milne, Aravind Ramesh, Javier T. Gonzalez, James A. Betts, Anthony E. PickeringList of authors in order
- Landing page
-
https://doi.org/10.1136/bmjopen-2024-086540Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1136/bmjopen-2024-086540Direct OA link when available
- Concepts
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Medicine, Parenteral nutrition, Enteral administration, Tolerability, Feeding tube, Randomized controlled trial, Population, Clinical nutrition, Clinical trial, Regimen, Protocol (science), Intensive care medicine, Pediatrics, Internal medicine, Surgery, Alternative medicine, Adverse effect, Pathology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
- References (count)
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38Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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