Does Timing Matter in Radiotherapy of Hepatocellular Carcinoma? Article Swipe
Soha A. Hassan
,
Amira A. H. Ali
,
Dennis Sohn
,
Uli Floegel
,
Reiner Jaenicke
,
Horst‐Werner Korf
,
Charlotte von Gall
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202101.0603.v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202101.0603.v1
This study investigates whether a chronotherapeutic treatment of hepatocellular carcinoma (HCC) may improve treatment efficacy and mitigate side effects on healthy liver (HL). HCC was induced in Per2::luc mice which were irradiated at four time points of the day. Proliferation and DNA-double strand breaks were investigated in irradiated and non-irradiated organotypic slice culture (OSC) and ex vivo samples by detection of Ki67 and γ-H2AX. OSC proved useful to determine dose-dependent effects on proliferation and DNA damage but appeared unsuited to test the chronotherapeutic approach. Irradiation of ex vivo samples was most effective at the proliferation peaks in HCC at ZT02 (early inactivity phase) and ZT20 (late activity phase). Irradiation effects on HL were minimal at ZT20. Ex vivo samples revealed disruption in daily variation and down-regulation of all investigated clock genes except Per1 in non-irradiated HCC as compared with HL. Irradiation affected rhythmic clock gene expression in HL and HCC at all ZTs except at ZT20. Irradiation at ZT20 had no effect on total leukocyte numbers. Our results indicate ZT20 as the optimal time point for irradiation of HCC in mice. Translational studies are now needed to evaluate whether the late activity phase is the optimal time point for irradiation of HCC in man.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202101.0603.v1
- https://www.preprints.org/manuscript/202101.0603/v1/download
- OA Status
- green
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3127902084
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3127902084Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.20944/preprints202101.0603.v1Digital Object Identifier
- Title
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Does Timing Matter in Radiotherapy of Hepatocellular Carcinoma?Work title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-29Full publication date if available
- Authors
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Soha A. Hassan, Amira A. H. Ali, Dennis Sohn, Uli Floegel, Reiner Jaenicke, Horst‐Werner Korf, Charlotte von GallList of authors in order
- Landing page
-
https://doi.org/10.20944/preprints202101.0603.v1Publisher landing page
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https://www.preprints.org/manuscript/202101.0603/v1/downloadDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.preprints.org/manuscript/202101.0603/v1/downloadDirect OA link when available
- Concepts
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Ex vivo, Hepatocellular carcinoma, PER1, Irradiation, In vivo, Cancer research, Biology, DNA damage, Cell cycle, Cancer, Chemistry, Gene, Gene expression, DNA, Genetics, CLOCK, Nuclear physics, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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61Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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