Dogs race through development Article Swipe
YOU?
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· 2020
· Open Access
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· DOI: https://doi.org/10.1126/science.369.6502.388-f
· OA: W3082553493
Aging To get a better understanding of epigenetic changes that occur during development and aging, Wang et al. compared lifetime changes in the DNA methylomes of dogs and humans. Changes in methylation of cytosine-guanine dinucleotides in DNA provide an epigenetic clock that corresponds to age in humans and other animals. The authors alleviated some technical difficulties to allow comparison of data from 104 Labrador retrievers with data from humans and mice. The dog methylomes remodeled quickly in early life, reflecting not just life span but also timing of developmental changes. The authors found a strong association of methylation changes in genes that control developmental pathways, indicating that aging is, in some respects, a continuation of development. Cell Syst. 11 , 1 (2020).
