DOP071. Endoscopic detection of small bowel adenocarcinoma and dysplasia in patients with jejuno-ileal Crohn's disease: prospective study in a cohort of high risk patients (DYDJI Study) Article Swipe
Federico Argüelles‐Arias
,
Antonio López–Sanromán
,
Xavier Calvet
,
Oscar Rincón
,
Cristina Romero
,
Daniel Carpio
,
M. Simon
,
Jacques Cosnes
,
Philippe Seksik
,
Matthieu Allez
,
Carmen Stefănescu
,
Antoine Blain
,
Maria Nachury
,
Stéphane Nancey
,
Lucine Vuitton
,
Geert D’Haens
,
Jérôme Filippi
,
Sylvie Chevret
,
David Laharie
,
A. Cassinotti
,
Federico Buffoli
,
Paolo Fociani
,
Vincenzo Villanacci
,
Teresa Staiano
,
Manuela Nebuloni
,
Maria Fichera
,
Roberto Grassia
,
Gianpiero Manes
,
Marianna Salemme
,
M. Lombardini
,
P. Molteni
,
Gianluca M. Sampietro
,
Federica Furfaro
,
Alessandra Dell’Era
,
Pietro Gambitta
,
Diego Foschi
,
Piergiorgio Duca
,
Roberto de Franchis
,
Giovanni Maconi
,
Sandro Ardizzone
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1093/ecco-jcc/jju027.099
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1093/ecco-jcc/jju027.099
Background: The PODIUM study (Dignass2009) and MOTUS study (Flourié,B.2011)proved the benefit of once daily (qd) mesalazine dosing vs twice daily (bd) dosing.Yet, the effect of real world dosing regimens on adherence and persistence is vital to ensure the most efficient regime is reached for patient and payer; reducing costs, hospitalisations and disease flares (Kane SV 2006).A multi country study was conducted to establish whether or not patients taking high strength mesalazines with a low posology show better adherence and persistence than patients taking lower strength mesalazines with a high posology burden.Also, whether or not a connection exists between these cohorts regarding IBD flare symptoms.Methods: A retrospective non-interventional database analysis across France and the UK; from May 2011 to May 2014 was conducted.Patients were studied as a whole group for adherence (medication possession ratio -MPR) and persistence in line with the distinct strength sets below: A: Low strength:<=(less than or equal to) 500mg B: Medium strength:<=1g C: Medium (High) strength:< =1.5g D: High strength: > (greater than)1.5gFor this study IBD flare is defined as: An increase in average dose per day of oral mesalazines by 50% or more (mg/day) OR Co-prescribing of a steroid or topical/enema mesalazine Case control study (rates of IBD flare): Patients in all four cohorts were naïve for all oral mesalazine drugs in the previous 6 months to the index date; they were 'stable' on treatment for at least 6 months.IBD flares were measured within the next 6 months.Results: The joint dataset yields n=32,607.Sex distribution is equal (females=0.50, males=0.50).Mean age was 54.8 (SD 18.1; range 18 -103).Daily intake of a single mesalazine dose has a direct link with better adherence over regimens greater than 2 per day (single dose mesalazine mean adherence =0.86).Patients taking one mesalazine to reach a daily dose of 2g (2000mg) display mean adherence of 0.88 (88%), patients taking two 1g doses to reach a daily dose of 2g show mean adherence of 0.77 (77%); significantly lower than the single dose cohort.Intake of one high dose mesalazine leads to better persistence vs multiple lower dose mesalazines.Also, patients taking one mesalazine dose of >1.5g daily show better persistence at 642 days.This result is significant when compared to categories C<=1.5g and B< =1g.Via a matched patient pair analysis of 2,464.Patients from the >1.5g cohort display much lower levels of IBD flare when compared to patients from the <=1.5g and <=1g cohorts (p=0.015 and p<0.001 respectively).Conclusions: We conclude that a daily intake of a single unit high dose mesalazine Results in better treatment adherence and persistence, with associated lower levels of disease flare.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ecco-jcc/jju027.099
- https://academic.oup.com/ecco-jcc/article-pdf/9/suppl_1/S63/1348781/jju027.099.pdf
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4252220576
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4252220576Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/ecco-jcc/jju027.099Digital Object Identifier
- Title
-
DOP071. Endoscopic detection of small bowel adenocarcinoma and dysplasia in patients with jejuno-ileal Crohn's disease: prospective study in a cohort of high risk patients (DYDJI Study)Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-02-01Full publication date if available
- Authors
-
Federico Argüelles‐Arias, Antonio López–Sanromán, Xavier Calvet, Oscar Rincón, Cristina Romero, Daniel Carpio, M. Simon, Jacques Cosnes, Philippe Seksik, Matthieu Allez, Carmen Stefănescu, Antoine Blain, Maria Nachury, Stéphane Nancey, Lucine Vuitton, Geert D’Haens, Jérôme Filippi, Sylvie Chevret, David Laharie, A. Cassinotti, Federico Buffoli, Paolo Fociani, Vincenzo Villanacci, Teresa Staiano, Manuela Nebuloni, Maria Fichera, Roberto Grassia, Gianpiero Manes, Marianna Salemme, M. Lombardini, P. Molteni, Gianluca M. Sampietro, Federica Furfaro, Alessandra Dell’Era, Pietro Gambitta, Diego Foschi, Piergiorgio Duca, Roberto de Franchis, Giovanni Maconi, Sandro ArdizzoneList of authors in order
- Landing page
-
https://doi.org/10.1093/ecco-jcc/jju027.099Publisher landing page
- PDF URL
-
https://academic.oup.com/ecco-jcc/article-pdf/9/suppl_1/S63/1348781/jju027.099.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/ecco-jcc/article-pdf/9/suppl_1/S63/1348781/jju027.099.pdfDirect OA link when available
- Concepts
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Medicine, Gastroenterology, Internal medicine, Dysplasia, Crohn's disease, Prospective cohort study, Inflammatory bowel disease, Disease, Cohort study, CohortTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| best_oa_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://academic.oup.com/ecco-jcc/article-pdf/9/suppl_1/S63/1348781/jju027.099.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Crohn's and Colitis |
| best_oa_location.landing_page_url | https://doi.org/10.1093/ecco-jcc/jju027.099 |
| primary_location.id | doi:10.1093/ecco-jcc/jju027.099 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2735960814 |
| primary_location.source.issn | 1873-9946, 1876-4479 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1873-9946 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Crohn s and Colitis |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| primary_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| primary_location.license | |
| primary_location.pdf_url | https://academic.oup.com/ecco-jcc/article-pdf/9/suppl_1/S63/1348781/jju027.099.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Crohn's and Colitis |
| primary_location.landing_page_url | https://doi.org/10.1093/ecco-jcc/jju027.099 |
| publication_date | 2015-02-01 |
| publication_year | 2015 |
| referenced_works_count | 0 |
| abstract_inverted_index.2 | 277 |
| abstract_inverted_index.6 | 218, 232, 240 |
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| abstract_inverted_index.A | 104 |
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| abstract_inverted_index.18 | 258 |
| abstract_inverted_index.1g | 306 |
| abstract_inverted_index.2g | 295, 314 |
| abstract_inverted_index.A: | 144 |
| abstract_inverted_index.An | 173 |
| abstract_inverted_index.B: | 152 |
| abstract_inverted_index.B< | 365 |
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| abstract_inverted_index.D: | 160 |
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| abstract_inverted_index.SV | 54 |
| abstract_inverted_index.We | 399 |
| abstract_inverted_index.as | 124 |
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| abstract_inverted_index.the | 9, 22, 37, 112, 139, 216, 221, 238, 324, 375, 390 |
| abstract_inverted_index.to) | 150 |
| abstract_inverted_index.two | 305 |
| abstract_inverted_index.was | 59, 120, 253 |
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| abstract_inverted_index.2014 | 119 |
| abstract_inverted_index.54.8 | 254 |
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| abstract_inverted_index.mean | 283, 298, 316 |
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| abstract_inverted_index.once | 12 |
| abstract_inverted_index.oral | 181, 212 |
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| abstract_inverted_index.-MPR) | 133 |
| abstract_inverted_index.18.1; | 256 |
| abstract_inverted_index.500mg | 151 |
| abstract_inverted_index.=1.5g | 159 |
| abstract_inverted_index.>1.5g | 348, 376 |
| abstract_inverted_index.MOTUS | 6 |
| abstract_inverted_index.daily | 13, 19, 292, 311, 349, 403 |
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| abstract_inverted_index.doses | 307 |
| abstract_inverted_index.drugs | 214 |
| abstract_inverted_index.equal | 149, 249 |
| abstract_inverted_index.flare | 102, 169, 384 |
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| abstract_inverted_index.reach | 290, 309 |
| abstract_inverted_index.study | 3, 7, 58, 167, 198 |
| abstract_inverted_index.these | 98 |
| abstract_inverted_index.twice | 18 |
| abstract_inverted_index.vital | 34 |
| abstract_inverted_index.whole | 126 |
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| abstract_inverted_index.(77%); | 320 |
| abstract_inverted_index.(88%), | 302 |
| abstract_inverted_index.(High) | 157 |
| abstract_inverted_index.(rates | 199 |
| abstract_inverted_index.<=1.5g | 391 |
| abstract_inverted_index.France | 110 |
| abstract_inverted_index.Medium | 153, 156 |
| abstract_inverted_index.PODIUM | 2 |
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| abstract_inverted_index.single | 263, 325, 407 |
| abstract_inverted_index.taking | 67, 82, 286, 304, 343 |
| abstract_inverted_index.within | 237 |
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| abstract_inverted_index.(single | 280 |
| abstract_inverted_index.2006).A | 55 |
| abstract_inverted_index.=1g.Via | 366 |
| abstract_inverted_index.C<=1.5g | 363 |
| abstract_inverted_index.Results | 412 |
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| abstract_inverted_index.benefit | 10 |
| abstract_inverted_index.between | 97 |
| abstract_inverted_index.cohorts | 99, 207, 394 |
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| abstract_inverted_index.defined | 171 |
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| abstract_inverted_index.display | 297, 378 |
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| abstract_inverted_index.p<0.001 | 397 |
| abstract_inverted_index.patient | 44, 369 |
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| abstract_inverted_index.steroid | 192 |
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| abstract_inverted_index.(2000mg) | 296 |
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| abstract_inverted_index.Patients | 203 |
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| abstract_inverted_index.patients | 66, 81, 303, 342, 388 |
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| abstract_inverted_index.mesalazines | 70, 85, 182 |
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| abstract_inverted_index.n=32,607.Sex | 246 |
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| abstract_inverted_index.(females=0.50, | 250 |
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| abstract_inverted_index.=0.86).Patients | 285 |
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| abstract_inverted_index.males=0.50).Mean | 251 |
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| abstract_inverted_index.non-interventional | 106 |
| abstract_inverted_index.(Flourié,B.2011)proved | 8 |
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| cited_by_percentile_year | |
| countries_distinct_count | 3 |
| institutions_distinct_count | 40 |
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| citation_normalized_percentile.is_in_top_10_percent | False |