Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia Article Swipe
Ao Li
,
Rui Li
,
Pengrong Ouyang
,
Huihui Li
,
Sa Wang
,
Xinxin Zhang
,
Dan Wang
,
Mingzi Ran
,
Guangchao Zhao
,
Qianzi Yang
,
Zhenghua Zhu
,
Hailong Dong
,
Haopeng Zhang
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/cns.13656
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/cns.13656
Aims General anesthesia has been widely applied in surgical or nonsurgical medical procedures, but the mechanism behind remains elusive. Because of shared neural circuits of sleep and anesthesia, whether serotonergic system, which is highly implicated in modulation of sleep and wakefulness, regulates general anesthesia as well is worth investigating. Methods Immunostaining and fiber photometry were used to assess the neuronal activities. Electroencephalography spectra and burst‐suppression ratio (BSR) were used to measure anesthetic depth and loss or recovery of righting reflex to indicate the induction or emergence time of general anesthesia. Regulation of serotonergic system was achieved through optogenetic, chemogenetic, or pharmacological methods. Results We found that both Fos expression and calcium activity were significantly decreased during general anesthesia. Activation of 5‐HT neurons in the dorsal raphe nucleus (DRN) decreased the depth of anesthesia and facilitated the emergence from anesthesia, and inhibition deepened the anesthesia and prolonged the emergence time. Furthermore, agonism or antagonism of 5‐HT 1A or 2C receptors mimicked the effect of manipulating DRN serotonergic neurons. Conclusion Our results demonstrate that 5‐HT neurons in the DRN play a regulative role of general anesthesia, and activation of serotonergic neurons could facilitate emergence from general anesthesia partly through 5‐HT 1A and 2C receptors.
Related Topics
Concepts
Serotonergic
Dorsal raphe nucleus
Anesthetic
Neuroscience
Raphe
Medicine
Anesthesia
Isoflurane
Serotonin
Brainstem
Optogenetics
Raphe nuclei
Nociception
5-HT receptor
Psychology
Receptor
Internal medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/cns.13656
- OA Status
- gold
- Cited By
- 45
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3162476260
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W3162476260Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/cns.13656Digital Object Identifier
- Title
-
Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesiaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-11Full publication date if available
- Authors
-
Ao Li, Rui Li, Pengrong Ouyang, Huihui Li, Sa Wang, Xinxin Zhang, Dan Wang, Mingzi Ran, Guangchao Zhao, Qianzi Yang, Zhenghua Zhu, Hailong Dong, Haopeng ZhangList of authors in order
- Landing page
-
https://doi.org/10.1111/cns.13656Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1111/cns.13656Direct OA link when available
- Concepts
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Serotonergic, Dorsal raphe nucleus, Anesthetic, Neuroscience, Raphe, Medicine, Anesthesia, Isoflurane, Serotonin, Brainstem, Optogenetics, Raphe nuclei, Nociception, 5-HT receptor, Psychology, Receptor, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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45Total citation count in OpenAlex
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2025: 13, 2024: 14, 2023: 10, 2022: 6, 2021: 2Per-year citation counts (last 5 years)
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37Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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