Dose Dependent Effects of Breynia cernua Against the Paraquat Induced Parkinsonism like Symptoms in Animals’ Model: In Vitro, In Vivo and Mechanistic Studies Article Swipe
Malik Saadullah
,
Sania Arif
,
Liaqat Hussain
,
Muhammad Asif
,
Umair Khurshid
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/15593258221125478
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/15593258221125478
The aims and objectives of the study were to evaluate the antiParkinson’s (PD) potential of B cernua (BCE). B cernua (Poir.) Müll. Arg. (B cernua) is a member of the Phyllanthaceae family. HPLC revealed the presence of various phytochemicals. Study was conducted for 40 days. After PD induction by paraquat behavioural studies were carried out. Biochemical parameters such as DPPH, NO-scavenging, Ferrous reducing power, MDA, GSH, CAT, SOD, acetylcholinesterase (AChE), neurotransmitter estimation and TNF-α and IL-6 levels were determined. DPPH, NO-scavenging and Ferrous reducing power assays showed 78.02%, 48.05% and 71.45% inhibitions, respectively. There was significant improvement in motor functions and coordination in a dose-dependent manner (50 < 250 < 500 mg/kg) in PD rat model. Biochemical markers; SOD, CAT, GPx and GSH showed significant restoration ( P < .001) while MDA showed significant decrease ( P < .05). The AChE level was significantly reduced ( P < .05) at 500 mg/kg while neurotransmitters were significantly improved ( P < .001) in a dose-dependent fashion. The ELISA results showed significant ( P < .001) down-regulation of IL-6 and TNF-α level. In conclusion, it is suggested that BCE has the potential to reduce the symptoms of PD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/15593258221125478
- OA Status
- gold
- Cited By
- 16
- References
- 54
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4295224459Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/15593258221125478Digital Object Identifier
- Title
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Dose Dependent Effects of Breynia cernua Against the Paraquat Induced Parkinsonism like Symptoms in Animals’ Model: In Vitro, In Vivo and Mechanistic StudiesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-07-01Full publication date if available
- Authors
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Malik Saadullah, Sania Arif, Liaqat Hussain, Muhammad Asif, Umair KhurshidList of authors in order
- Landing page
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https://doi.org/10.1177/15593258221125478Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1177/15593258221125478Direct OA link when available
- Concepts
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Paraquat, Aché, Acetylcholinesterase, Pharmacology, DPPH, In vivo, Antioxidant, In vitro, Glutathione, Hydroxydopamine, Parkinsonism, Chemistry, Biology, Biochemistry, Internal medicine, Medicine, Enzyme, Parkinson's disease, Biotechnology, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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16Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 6, 2023: 7, 2022: 1Per-year citation counts (last 5 years)
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54Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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