Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approach Article Swipe
Zahra Yousefi
,
Zahra Mirsanei
,
Fatemeh Sadat Bitaraf
,
Sepideh Mahdavi
,
Mehdi Mirzaii
,
Reza Jafari
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/03946320221086084
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/03946320221086084
Introduction: Rheumatoid arthritis (RA) is an autoimmune disease that is identified with chronic inflammation and progressive destruction of the joints. The defective activity of regulatory T cells (Tregs) plays a crucial role in RA development. Oleuropein (OLEU) is the most common polyphenolic compound in olive leaf extracts with numerous pharmacological activities. In this study, the potential effects of OLEU in shifting CD4 + T cells toward Tregs are evaluated in patients with RA. Methods 32 healthy controls (HC) and 45 RA patients were included in two groups. The immunoturbidometric technique was used to measure serum levels of c-reactive protein (CRP) and rheumatoid factor (RF). Isolated CD4 + T cells from peripheral blood mononuclear cells (PBMCs) of HC and RA patients were cultured with appropriate concentrations of OLEU. The cytotoxicity effects of OLEU were determined using the MTT assay at 24, 48, and 72 h. The percentage of CD4 + CD25 + FoxP3 regulatory T lymphocytes (Tregs) and the expressions of IL-10 and TGF-β were evaluated by flow cytometry and immunoassay techniques after treatment of cells with different concentrations of OLEU for 24 h. The serum levels of RF and CRP in patients with RA were 11.8 ± 5.32 IU/ml and 6.36 ± 5.82 mg/l, respectively. Results OLEU had a dose-dependent effect on the CD4 + T cells via increasing the frequency of CD4 + CD25 + FoxP3 Tregs ( p = 0.0001). Moreover, it induced the production of IL-10 ( p = 0.0001) and TGF-β ( p < 0.01) in both HC and RA patients. Conclusion The findings of this study suggest that OLEU may have immunomodulatory effects by inducing Tregs, and it might help in developing a novel nutrition strategy for management of autoimmune diseases such as RA.
Related Topics
Concepts
Rheumatoid arthritis
IL-2 receptor
Medicine
FOXP3
Oleuropein
Peripheral blood mononuclear cell
Immunology
Arthritis
Flow cytometry
Internal medicine
Rheumatoid factor
Cytotoxicity
Synovial fluid
Pharmacology
In vitro
T cell
Chemistry
Immune system
Osteoarthritis
Pathology
Biochemistry
Antioxidant
Alternative medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/03946320221086084
- OA Status
- gold
- Cited By
- 15
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4223547009
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4223547009Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/03946320221086084Digital Object Identifier
- Title
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Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approachWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-04-01Full publication date if available
- Authors
-
Zahra Yousefi, Zahra Mirsanei, Fatemeh Sadat Bitaraf, Sepideh Mahdavi, Mehdi Mirzaii, Reza JafariList of authors in order
- Landing page
-
https://doi.org/10.1177/03946320221086084Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1177/03946320221086084Direct OA link when available
- Concepts
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Rheumatoid arthritis, IL-2 receptor, Medicine, FOXP3, Oleuropein, Peripheral blood mononuclear cell, Immunology, Arthritis, Flow cytometry, Internal medicine, Rheumatoid factor, Cytotoxicity, Synovial fluid, Pharmacology, In vitro, T cell, Chemistry, Immune system, Osteoarthritis, Pathology, Biochemistry, Antioxidant, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 4, 2023: 6, 2022: 4Per-year citation counts (last 5 years)
- References (count)
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69Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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