Double trouble: Unmasking two hook effects on Siemens Atellica® - Total PSA and total hCG assays Article Swipe
Meryem Benamour
,
Pauline Brouwers
,
Arnaud Nevraumont
,
Tatiana Roy
,
Jean‐Louis Bayart
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.plabm.2024.e00366
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.plabm.2024.e00366
The "hook effect" or "prozone phenomenon" occurs when the concentration of a particular analyte saturates the antibodies used in the test, resulting in falsely low or negative results despite the presence of high analyte concentrations. We report two recent cases of hook effect encountered with a widely used immunoassay analyzer, the Siemens Atellica® IM1600. The first case involves a patient with advanced metastatic prostate cancer whose total PSA (tPSA) concentration dropped dramatically from his last biological control. The second case concerns a pregnant woman whose total HCG (ThCG) levels were also subject to the hook effect and who was found to have a molar pregnancy. In both cases, a dilution step enabled to overcome this analytical concern and to obtain a correct result. In addition, a comparison of the sensitivity of different immunoassay analyzers to this phenomenon was carried out. To avoid this analytical error, an additional dilution step should automatically be performed when there is a clinical suspicion of elevated levels of tumor or hormone markers. Finally, the most affected manufacturers should adapt their assays, accordingly.
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- Type
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- Language
- en
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- OA Status
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- OpenAlex ID
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All OpenAlex metadata
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https://doi.org/10.1016/j.plabm.2024.e00366Digital Object Identifier
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Double trouble: Unmasking two hook effects on Siemens Atellica® - Total PSA and total hCG assaysWork title
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articleOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-01-30Full publication date if available
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Meryem Benamour, Pauline Brouwers, Arnaud Nevraumont, Tatiana Roy, Jean‐Louis BayartList of authors in order
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https://doi.org/10.1016/j.plabm.2024.e00366Publisher landing page
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.plabm.2024.e00366Direct OA link when available
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Analyte, Immunoassay, Hook, Siemens, Medicine, Chromatography, Antibody, Chemistry, Immunology, Physics, Quantum mechanics, DentistryTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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