Downregulation of BRAF‑activated non‑protein coding RNA in patients with hepatitis B virus‑associated hepatocellular carcinoma Article Swipe
Nana Zhao
,
Cheng Wang
,
Chengcai Lai
,
Sijie Cheng
,
Yan Jin
,
Zhixian Hong
,
Linxiang Yu
,
Zhenyu Zhu
,
Peirui Zhang
,
Zhaohai Wang
,
Xi‐Liang Wang
,
Shao‐Geng Zhang
,
Penghui Yang
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3892/ol.2018.8327
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3892/ol.2018.8327
Long non-coding RNAs (lncRNAs) have been investigated as a novel class of regulators of cellular processes, including cell growth, apoptosis and carcinogenesis. lncRNA BRAF-activated non-protein coding RNA (BANCR) has recently been revealed to be involved in tumorigenesis of numerous types of cancer, including papillary thyroid carcinoma, melanoma, non-small cell lung cancer and colorectal cancer. However, the expression profiles and biological relevance of lncRNA BANCR in hepatocellular carcinoma (HCC) has not yet been reported. In the present study, the expression level of BANCR in tumor tissues and para-cancerous tissues was determined by reverse transcription-quantitative polymerase chain reaction in patients with hepatitis B virus (HBV)-associated HCC, and its association with clinicopathological characteristics of patients was analyzed. The results demonstrated that the expression level of BANCR was significantly reduced in tumor tissues in comparison with in para-cancerous tissues (P<0.001). Furthermore, the present study demonstrated that BANCR expression level was closely associated with serum α-fetoprotein levels (P<0.01) and HCC tumor number (P<0.05). To the best of our knowledge, these results revealed for the first time that BANCR downregulated in patients with HBV-associated HCC and BANCR expression level may be a potential valuable diagnosis and therapeutic biomarker in HCC.
Related Topics
Concepts
Oncogene
Carcinogenesis
Hepatocellular carcinoma
Cancer research
Molecular medicine
Cell cycle
Long non-coding RNA
Hepatitis B virus
Cancer
Medicine
RNA
Biology
Virus
Virology
Gene
Internal medicine
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/ol.2018.8327
- http://www.spandidos-publications.com/10.3892/ol.2018.8327/download
- OA Status
- diamond
- Cited By
- 10
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2791394453
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2791394453Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3892/ol.2018.8327Digital Object Identifier
- Title
-
Downregulation of BRAF‑activated non‑protein coding RNA in patients with hepatitis B virus‑associated hepatocellular carcinomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-03-22Full publication date if available
- Authors
-
Nana Zhao, Cheng Wang, Chengcai Lai, Sijie Cheng, Yan Jin, Zhixian Hong, Linxiang Yu, Zhenyu Zhu, Peirui Zhang, Zhaohai Wang, Xi‐Liang Wang, Shao‐Geng Zhang, Penghui YangList of authors in order
- Landing page
-
https://doi.org/10.3892/ol.2018.8327Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/ol.2018.8327/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.spandidos-publications.com/10.3892/ol.2018.8327/downloadDirect OA link when available
- Concepts
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Oncogene, Carcinogenesis, Hepatocellular carcinoma, Cancer research, Molecular medicine, Cell cycle, Long non-coding RNA, Hepatitis B virus, Cancer, Medicine, RNA, Biology, Virus, Virology, Gene, Internal medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 3, 2023: 1, 2022: 1, 2021: 2, 2020: 3Per-year citation counts (last 5 years)
- References (count)
-
39Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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