Downregulation of hnRNPA1 inhibits hepatocellular carcinoma cell progression by modulating alternative splicing of ZNF207 exon 9 Article Swipe
Qi Ouyang
,
Wenhui He
,
Yiping Guo
,
Lin Li
,
Ying Mao
,
Xiang Li
,
Shuanglin Xiang
,
Xiang Hu
,
Jun He
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1517459
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1517459
Introduction Hepatocellular carcinoma (HCC) is the most prevalent liver cancer and a leading cause of cancer-related deaths worldwide. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) plays a critical role in RNA metabolism, including alternative splicing, which is linked to cancer progression. Our study investigated the role of hnRNPA1 in HCC and its potential as a therapeutic target. Methods We analyzed hnRNPA1 expression in HCC tissues compared to non-tumor tissues using RNA-seq and immunohistochemistry. hnRNPA1 was knocked down in Hep G2 cells to assess its impact on cell proliferation, migration, and apoptosis using scratch assays, flow cytometry, qPCR, and Western blot. We also explored the interaction between hnRNPA1 and ZNF207, as well as its splicing effects and downstream signaling pathways by RIP assay, bioinformatics, qPCR and Western blot. Results hnRNPA1 was significantly upregulated in HCC tissues compared to normal tissues, correlating with poor patient survival. hnRNPA1 knockdown reduced Hep G2 cell proliferation and migration while increasing apoptosis. We identified that hnRNPA1 bound to ZNF207 and regulated its exon 9 skipping, influencing ZNF207 splicing and the PI3K/Akt/mTOR pathway, key regulators of cell growth and survival. Conclusion Our findings demonstrate that hnRNPA1 promotes HCC progression by regulating ZNF207 splicing and the PI3K/Akt/mTOR pathway. hnRNPA1-ZNF207 interaction represents a potential therapeutic target for HCC, providing insights into the molecular mechanisms underlying HCC progression.
Related Topics
Concepts
Downregulation and upregulation
Hepatocellular carcinoma
Exon
Alternative splicing
Cancer research
Chemistry
Biology
Gene
Genetics
Metadata
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- en
- Landing Page
- https://doi.org/10.3389/fonc.2024.1517459
- OA Status
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- References
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All OpenAlex metadata
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https://openalex.org/W4406083046Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2024.1517459Digital Object Identifier
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Downregulation of hnRNPA1 inhibits hepatocellular carcinoma cell progression by modulating alternative splicing of ZNF207 exon 9Work title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-01-06Full publication date if available
- Authors
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Qi Ouyang, Wenhui He, Yiping Guo, Lin Li, Ying Mao, Xiang Li, Shuanglin Xiang, Xiang Hu, Jun HeList of authors in order
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https://doi.org/10.3389/fonc.2024.1517459Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fonc.2024.1517459Direct OA link when available
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Downregulation and upregulation, Hepatocellular carcinoma, Exon, Alternative splicing, Cancer research, Chemistry, Biology, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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