DRESS syndrome due to first-line antitubercular therapy – A diagnostic imbroglio! Article Swipe
Pratap Kumar Patra
,
Aaqib Zaffar Banday
,
Ankur Kumar Jindal
,
Dharmagat Bhattarai
,
Nilamani Patra
,
Uma Nahar Saikia
,
Anju Gupta
,
Deepti Suri
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.4103/jfmpc.jfmpc_1031_21
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.4103/jfmpc.jfmpc_1031_21
A BSTRACT Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after the use of first-line antitubercular drugs (ATDs) is rare and literature regarding DRESS syndrome due to ATDs is scarce in children. We report a young boy with tuberculosis who developed DRESS syndrome after exposure to isoniazid. A 9-year-old boy, diagnosed clinically as pulmonary tuberculosis, presented with fever, fast breathing, maculopapular rash, and one episode of gross hematuria. He had been on 4-drug ATD therapy (isoniazid, rifampicin, ethambutol, and pyrazinamide) for the past 4 weeks. In view of multiorgan involvement and absence of a microbiological diagnosis of tuberculosis, vasculitis was considered and he was treated with steroids. As the child recovered, both corticosteroids and ATD therapy were stopped. At 6 months of follow-up, he was presented with pneumonia. Microbiological diagnosis of tuberculosis was made and 4-drug ATD therapy was reinitiated. After 15 days, he again developed a high-grade fever and rash. On evaluation, isoniazid-induced DRESS syndrome was diagnosed. Subsequently, he received a modified regimen of ethambutol, pyrazinamide, levofloxacin, and linezolid. DRESS syndrome did not recur on these ATDs and the child became asymptomatic. Linezolid was stopped after 3 months of therapy and ethambutol, pyrazinamide, and levofloxacin are being continued. Currently, he has completed 15 months of modified ATD therapy. As a high index of suspicion is required for early diagnosis and management that are crucial to reducing morbidity and mortality, DRESS syndrome should be among the differentials in children with unexplained febrile illnesses.
Related Topics
Concepts
Medicine
Pyrazinamide
Ethambutol
Rifampicin
Tuberculosis
Isoniazid
Pediatrics
Maculopapular rash
Levofloxacin
Surgery
Asymptomatic
Rash
Dermatology
Antibiotics
Pathology
Microbiology
Biology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/jfmpc.jfmpc_1031_21
- OA Status
- gold
- Cited By
- 3
- References
- 9
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285144005
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285144005Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4103/jfmpc.jfmpc_1031_21Digital Object Identifier
- Title
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DRESS syndrome due to first-line antitubercular therapy – A diagnostic imbroglio!Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-06-01Full publication date if available
- Authors
-
Pratap Kumar Patra, Aaqib Zaffar Banday, Ankur Kumar Jindal, Dharmagat Bhattarai, Nilamani Patra, Uma Nahar Saikia, Anju Gupta, Deepti SuriList of authors in order
- Landing page
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https://doi.org/10.4103/jfmpc.jfmpc_1031_21Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.4103/jfmpc.jfmpc_1031_21Direct OA link when available
- Concepts
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Medicine, Pyrazinamide, Ethambutol, Rifampicin, Tuberculosis, Isoniazid, Pediatrics, Maculopapular rash, Levofloxacin, Surgery, Asymptomatic, Rash, Dermatology, Antibiotics, Pathology, Microbiology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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9Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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