Drug Repurposing: A New Hope in Drug Discovery for Prostate Cancer Article Swipe
Jonaid Ahmad Malik
,
Sakeel Ahmed
,
Sadiya Sikandar Momin
,
Sijal Shaikh
,
Ahmed Alafnan
,
Jowaher Alanazi
,
Mohammad Almermesh
,
Sirajudheen Anwar
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.2c05821
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.2c05821
Prostate cancer (PCA), the most common cancer in men, accounted for 1.3 million new incidences in 2018. An increase in incidences is an issue of concern that should be addressed. Of all the reported prostate cancers, 85% were detected in stages III and IV, making them difficult to treat. Conventional drugs gradually lose their efficacy due to the developed resistance against them, thus requiring newer therapeutic agents to be used as monotherapy or combination. Recent research regarding treatment options has attained remarkable speed and development. Therefore, in this context, drug repurposing comes into the picture, which is defined as the "investigation of the off-patent, approved and marketed drugs for a novel therapeutic indication" which saves at least 30% of the time and cost, reducing the cost of treatment for patients, which usually runs high in cancer patients. The anticancer property of cardiac glycosides in cancers was tested in the early 1980s. The trend then shifts toward treating prostate cancer by repurposing other cardiovascular drugs. The current review mainly emphasizes the advantageous antiprostate cancer profile of conventional CVS drugs like cardiac glycosides, RAAS inhibitors, statins, heparin, and beta-blockers with underlying mechanisms.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsomega.2c05821
- https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c05821
- OA Status
- gold
- Cited By
- 20
- References
- 126
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313270507
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4313270507Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acsomega.2c05821Digital Object Identifier
- Title
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Drug Repurposing: A New Hope in Drug Discovery for Prostate CancerWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-12-29Full publication date if available
- Authors
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Jonaid Ahmad Malik, Sakeel Ahmed, Sadiya Sikandar Momin, Sijal Shaikh, Ahmed Alafnan, Jowaher Alanazi, Mohammad Almermesh, Sirajudheen AnwarList of authors in order
- Landing page
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https://doi.org/10.1021/acsomega.2c05821Publisher landing page
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https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c05821Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c05821Direct OA link when available
- Concepts
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Medicine, Prostate cancer, Repurposing, Drug repositioning, Drug, Cancer, Context (archaeology), Cancer drugs, Prostate, Intensive care medicine, Pharmacology, Oncology, Internal medicine, Paleontology, Ecology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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20Total citation count in OpenAlex
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2025: 3, 2024: 6, 2023: 11Per-year citation counts (last 5 years)
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126Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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