Drug repurposing: isosorbide mononitrate enhances tumor accumulation to augment sonodynamic therapy for hepatocellular carcinoma Article Swipe
Yu Peng
,
Zhe Li
,
Lei Zhou
,
Jian Qian
,
Baoli Yin
,
Bo Sun
,
Yinghui Song
,
Hao Chen
,
Xian-Zheng Tan
,
Xiaohui Duan
,
Sulai Liu
,
Chuang Peng
,
Guosheng Song
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12951-025-03674-7
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12951-025-03674-7
Hepatocellular carcinoma (HCC) remains a leading cause of cancer death worldwide. Sonodynamic therapy (SDT) offers a non-invasive, deep-penetrating approach by using ultrasound to activate sonosensitizers and generate cytotoxic reactive oxygen species (ROS). Yet poor intratumoral delivery and low ROS quantum yields of existing agents have stalled clinical translation. Here, we present a synergistic SDT platform that overcomes these barriers by combining transient vasodilation of tumor microvessels with the clinically widely used Antianginal drug isosorbide mononitrate and an acceptor-donor-acceptor-donor-acceptor type organic nanosonosensitizer (BTz) engineered for a narrow bandgap and enhanced ultrasound responsiveness. Isosorbide mononitrate increases nanosonosensitizer accumulation by ~ 1.8-fold. Under ultrasound irradiation, nanosonosensitizer produced high ROS generation, resulting in 78% tumor growth inhibition in murine HCC models-nearly double that of SDT alone-without detectable systemic toxicity. Crucially, the near-infrared fluorescence of nanosonosensitizer enabled real-time, image-guided tracking of sonosensitizer uptake and therapeutic response. By repurposing a safe vasodilator and integrating it with a high-performance organic sonosensitizer, this work establishes a readily translatable, minimally invasive paradigm for precise SDT of localized, inoperable or metastatic HCC.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12951-025-03674-7
- https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03674-7
- OA Status
- gold
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413541728
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413541728Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s12951-025-03674-7Digital Object Identifier
- Title
-
Drug repurposing: isosorbide mononitrate enhances tumor accumulation to augment sonodynamic therapy for hepatocellular carcinomaWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-08-25Full publication date if available
- Authors
-
Yu Peng, Zhe Li, Lei Zhou, Jian Qian, Baoli Yin, Bo Sun, Yinghui Song, Hao Chen, Xian-Zheng Tan, Xiaohui Duan, Sulai Liu, Chuang Peng, Guosheng SongList of authors in order
- Landing page
-
https://doi.org/10.1186/s12951-025-03674-7Publisher landing page
- PDF URL
-
https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03674-7Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03674-7Direct OA link when available
- Concepts
-
Sonodynamic therapy, Hepatocellular carcinoma, Cancer research, Pharmacology, Oncolytic virus, Chemistry, Medicine, Apoptosis, Cancer, Internal medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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62Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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