Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models Article Swipe
Shengying Lin
,
Roy Wai-Lun Tang
,
Yutong Ye
,
Chenxi Xia
,
Jiahui Wu
,
Ran Duan
,
Ka Wing Leung
,
Tina Ting-Xia Dong
,
Karl Wah Keung Tsim
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/molecules30020257
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/molecules30020257
Vascular endothelial growth factor (VEGF), also known as VEGF-A, has been linked to various diseases, such as wet age-related macular degeneration (wAMD) and cancer. Even though there are VEGF inhibitors that are currently commercially available in clinical applications, severe adverse effects have been associated with these treatments. There is still a need to develop novel VEGF-based therapeutics against these VEGF-related diseases. Here, we established a series of VEGF-based computational docking analyses and cell models, such as a wound healing assay in HaCaT cells and an evaluation of NF-κB performance in macrophages, to screen a large library of flavonoid-type phytochemicals. Three flavonoids, namely, farrerol, ononin and (−)-epicatechin, were shown to express binding affinities to VEGF protein and inhibit VEGF-mediated biological activities. The investigation evidently suggested that the three flavonoids above could be considered potential anti-VEGF agents for the following drug development against VEGF-mediated diseases.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules30020257
- OA Status
- gold
- Cited By
- 1
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406245391
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406245391Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/molecules30020257Digital Object Identifier
- Title
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Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell ModelsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-10Full publication date if available
- Authors
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Shengying Lin, Roy Wai-Lun Tang, Yutong Ye, Chenxi Xia, Jiahui Wu, Ran Duan, Ka Wing Leung, Tina Ting-Xia Dong, Karl Wah Keung TsimList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules30020257Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/molecules30020257Direct OA link when available
- Concepts
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Docking (animal), VEGF receptors, Computational biology, Chemistry, Pharmacology, Computer science, Biology, Medicine, Cancer research, NursingTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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