Drug Use After Emergency Department‐Initiated Injectable Buprenorphine: A Secondary Analysis of the ED ‐ INNOVATION Ancillary Safety and Feasibility Trial
Article Swipe
Ethan Cowan
,
Gail D’Onofrio
,
Jeanmarie Perrone
,
Erik Anderson
,
James Dziura
,
Kathryn Hawk
,
Andrew Herring
,
Ryan McCormack
,
Manali Phadke
,
Elizabeth A. Samuels
,
David A. Fiellin
,
Ethan Cowan
,
Gail D’Onofrio
,
Jeanmarie Perrone
,
Erik Anderson
,
James Dziura
,
Kathryn Hawk
,
Andrew Herring
,
Ryan McCormack
,
Manali Phadke
,
Elizabeth A. Samuels
,
David A. Fiellin
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/acem.70191
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/acem.70191
Study Objective To characterize opioid and nonopioid drug use in the week following emergency department (ED)‐initiated extended‐release buprenorphine (XR‐BUP) treatment using both self‐reported data and urine drug screens (UDS). Methods This study uses data collected during a nonrandomized clinical trial of patients with untreated opioid use disorder (OUD), testing the safety and feasibility of initiating XR‐BUP in patients presenting with minimal to mild withdrawal. The study was conducted from July 2020 to May 2023 across four urban academic EDs in the Northeast, Mid‐Atlantic, and Pacific regions of the United States. A total of 100 participants, 18 years or older with OUD defined by DSM‐5 criteria, a clinical opiate withdrawal scale (COWS < 8), and a positive opioid urine screen were included. Individuals with recent MOUD treatment, presentation for overdose, or concurrent methadone use were excluded. All participants received a single subcutaneous injection of 24 mg XR‐BUP (CAM2038) during their ED visit. The primary outcomes were self‐reported daily opioid and nonopioid drug use over 7 days postinjection using daily Qualtrics surveys and UDS results on day 7. Results Among participants who received XR‐BUP and completed daily surveys, 98% reported at least one opioid‐free day, and 63% reported no opioid use across all 7 days. Day 7 UDS results showed decreased detection of opioids, stimulants, and benzodiazepines. Reported polysubstance use also declined over the observation period. Conclusions ED‐initiated XR‐BUP was associated with substantial reductions in opioid and polysubstance use during the first week post‐discharge, supporting its role in early overdose risk mitigation and highlighting its value as an ED‐based intervention for opioid use disorder. Trial Registration ClinicalTrials.gov Identifier: NCT03658642
Related Topics
Concepts
Medicine
Polysubstance dependence
Buprenorphine
Opioid use disorder
Methadone
Emergency department
Opioid
Drug
Emergency medicine
Opiate
Opiate Substitution Treatment
Urinalysis
Clinical trial
Opioid overdose
Morphine
Methadone maintenance
Anesthesia
Urine
Discontinuation
Substance abuse
Hydromorphone
(+)-Naloxone
Retrospective cohort study
Internal medicine
Young adult
Oxycodone
Drug overdose
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/acem.70191
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acem.70191
- OA Status
- hybrid
- References
- 28
- OpenAlex ID
- https://openalex.org/W7106575392
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106575392Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/acem.70191Digital Object Identifier
- Title
-
Drug Use After Emergency Department‐Initiated Injectable Buprenorphine: A Secondary Analysis of the
ED ‐INNOVATION Ancillary Safety and Feasibility TrialWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-24Full publication date if available
- Authors
-
Ethan Cowan, Gail D’Onofrio, Jeanmarie Perrone, Erik Anderson, James Dziura, Kathryn Hawk, Andrew Herring, Ryan McCormack, Manali Phadke, Elizabeth A. Samuels, David A. Fiellin, Ethan Cowan, Gail D’Onofrio, Jeanmarie Perrone, Erik Anderson, James Dziura, Kathryn Hawk, Andrew Herring, Ryan McCormack, Manali Phadke, Elizabeth A. Samuels, David A. FiellinList of authors in order
- Landing page
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https://doi.org/10.1111/acem.70191Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acem.70191Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acem.70191Direct OA link when available
- Concepts
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Medicine, Polysubstance dependence, Buprenorphine, Opioid use disorder, Methadone, Emergency department, Opioid, Drug, Emergency medicine, Opiate, Opiate Substitution Treatment, Urinalysis, Clinical trial, Opioid overdose, Morphine, Methadone maintenance, Anesthesia, Urine, Discontinuation, Substance abuse, Hydromorphone, (+)-Naloxone, Retrospective cohort study, Internal medicine, Young adult, Oxycodone, Drug overdoseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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28Number of works referenced by this work
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