DSCC: disease subtyping using spectral clustering and community detection from consensus networks Article Swipe
Dao Tran
,
Van-Dung Pham
,
Ha Nam Nguyen
,
Phi Bya
,
Aiham Qdaisat
,
Liem Phan
,
Sai‐Ching J. Yeung
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/bib/bbaf600
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/bib/bbaf600
Molecular subtyping is fundamental in cancer research and clinical management of cancer, guiding treatment planning, monitoring therapeutic response, and informing prognosis. Early methods were designed specifically for gene expression data due to the lack of other molecular data types. Thanks to breakthroughs in high-throughput technologies, recent subtyping tools have shifted their focus to integrating multi-omics profiles to uncover novel subtypes that better reflect genetic variation, molecular pathogenesis, tumor heterogeneity, and host response biological mechanisms. However, these integrative approaches have not been able to fully exploit the complementary potentials of diverse molecular data types. They often rely on specific omics types with large common sample size and fail to incorporate important biological knowledge in their models. Here, we introduce Disease subtyping using Spectral clustering and Community detection from Consensus networks (DSCC), a method designed to identify meaningful disease subtypes from a wide range of molecular data, including gene expression, miRNA expression, DNA methylation, copy number variation, somatic mutations, protein abundance, and metabolite levels. We demonstrate the superiority of DSCC over state-of-the-art cancer subtyping methods using 43 cancer datasets with more than 11,000 patients. Furthermore, the incorporation of DSCC-derived subtype information as a covariate in prognostic models improves survival prediction accuracy and robustness. The DSCC source code, data, and scripts for reproducing all results in this study are available at https://github.com/tinnlab/DSCC.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/bib/bbaf600
- https://academic.oup.com/bib/article-pdf/26/6/bbaf600/65275908/bbaf600.pdf
- OA Status
- gold
- References
- 95
- OpenAlex ID
- https://openalex.org/W4416205233
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- OpenAlex ID
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https://openalex.org/W4416205233Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/bib/bbaf600Digital Object Identifier
- Title
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DSCC: disease subtyping using spectral clustering and community detection from consensus networksWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-11-01Full publication date if available
- Authors
-
Dao Tran, Van-Dung Pham, Ha Nam Nguyen, Phi Bya, Aiham Qdaisat, Liem Phan, Sai‐Ching J. YeungList of authors in order
- Landing page
-
https://doi.org/10.1093/bib/bbaf600Publisher landing page
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https://academic.oup.com/bib/article-pdf/26/6/bbaf600/65275908/bbaf600.pdfDirect link to full text PDF
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goldOpen access status per OpenAlex
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https://academic.oup.com/bib/article-pdf/26/6/bbaf600/65275908/bbaf600.pdfDirect OA link when available
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0Total citation count in OpenAlex
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95Number of works referenced by this work
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