Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia Article Swipe

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Marina Wierz , Sandrine Pierson , Léa Guyonnet , Elodie Viry , Audrey Lequeux , Anaïs Oudin , Simone P. Niclou , Markus Ollert , Guy Berchem , Bassam Janji , Coralie L. Guérin , Jérôme Paggetti , Etienne Moussay ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.1182/blood-2017-06-792267

TO THE EDITOR: Tissue-infiltrating chronic lymphocytic leukemia (CLL) cells come in direct contact with both accessory stromal and immune cells that compose the tumor microenvironment (TME). The proliferation and survival of CLL cells is highly dependent on complex interactions with nonmalignant

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Chronic lymphocytic leukemia Tumor microenvironment Stromal cell Cancer research Immune checkpoint Immune system Blockade Ibrutinib Leukemia Medicine Immunology Biology Immunotherapy Receptor Internal medicine

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Type: letter
Language: en
Landing Page: https://doi.org/10.1182/blood-2017-06-792267
PDF: https://ashpublications.org/blood/article-pdf/131/14/1617/1406109/blood792267.pdf
OA Status: bronze
Cited By: 137
References: 19
Related Works: 10
OpenAlex ID: https://openalex.org/W2787624638

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OpenAlex ID: https://openalex.org/W2787624638

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DOI: https://doi.org/10.1182/blood-2017-06-792267

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Title: Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia

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Type: letter

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Language: en

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Publication year: 2018

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Publication date: 2018-02-13

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Authors: Marina Wierz, Sandrine Pierson, Léa Guyonnet, Elodie Viry, Audrey Lequeux, Anaïs Oudin, Simone P. Niclou, Markus Ollert, Guy Berchem, Bassam Janji, Coralie L. Guérin, Jérôme Paggetti, Etienne Moussay

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Landing page: https://doi.org/10.1182/blood-2017-06-792267

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PDF URL: https://ashpublications.org/blood/article-pdf/131/14/1617/1406109/blood792267.pdf

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OA status: bronze

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OA URL: https://ashpublications.org/blood/article-pdf/131/14/1617/1406109/blood792267.pdf

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Concepts: Chronic lymphocytic leukemia, Tumor microenvironment, Stromal cell, Cancer research, Immune checkpoint, Immune system, Blockade, Ibrutinib, Leukemia, Medicine, Immunology, Biology, Immunotherapy, Receptor, Internal medicine

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Cited by: 137

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Citations by year (recent): 2025: 8, 2024: 14, 2023: 18, 2022: 22, 2021: 24

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References (count): 19

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Related works (count): 10

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