Durative sleep fragmentation with or without hypertension suppress rapid eye movement sleep and generate cerebrovascular dysfunction Article Swipe
Xue Yang
,
Jie Tang
,
Miaoyi Zhang
,
Yifan He
,
Jianhui Fu
,
Fengfei Ding
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.nbd.2023.106222
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.nbd.2023.106222
Either hypertension or chronic insomnia is the risk factor of developing vascular dementia. Durative hypertension can induce vascular remodeling and is used for modeling small vessel disease in rodents. It remains undetermined if the combination of hypertension and sleep disturbance exacerbates vascular dysfunction or pathologies. Previously, we found chronic sleep fragmentation (SF) dampened cognition in young mice without disease predispositions. In the current study, we superimposed SF with hypertension modeling in young mice. Angiotensin II (AngII)-releasing osmotic mini pumps were subcutaneously implanted to generate persistent hypertension, while sham surgeries were performed as controls. Sleep fragmentation with repetitive arousals (10 s every 2 min) during light-on 12 h for consecutive 30 days, while mice undergoing normal sleep (NS) processes were set as controls. Sleep architectures, whisker-stimulated cerebral blood flow (CBF) changes, vascular responsiveness as well as vascular pathologies were compared among normal sleep plus sham (NS + sham), SF plus sham (SF + sham), normal sleep plus AngII (NS + AngII), and SF plus AngII (SF + AngII) groups. SF and hypertension both alter sleep structures, particularly suppressing REM sleep. SF no matter if combined with hypertension strongly suppressed whisker-stimulated CBF increase, suggesting the tight association with cognitive decline. Hypertension modeling sensitizes vascular responsiveness toward a vasoactive agent, Acetylcholine (ACh, 5 mg/ml, 10 μl) delivered via cisterna magna infusion, while SF exhibits a similar but much milder effect. None of the modeling above was sufficient to induce arterial or arteriole vascular remodeling, but SF or SF plus hypertension increased vascular network density constructed by all categories of cerebral vessels. The current study would potentially help understand the pathogenesis of vascular dementia, and the interconnection between sleep and vascular health.
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- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1016/j.nbd.2023.106222
- OA Status
- gold
- Cited By
- 11
- References
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- Related Works
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- OpenAlex ID
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https://openalex.org/W4383215547Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.nbd.2023.106222Digital Object Identifier
- Title
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Durative sleep fragmentation with or without hypertension suppress rapid eye movement sleep and generate cerebrovascular dysfunctionWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2023Year of publication
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2023-07-05Full publication date if available
- Authors
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Xue Yang, Jie Tang, Miaoyi Zhang, Yifan He, Jianhui Fu, Fengfei DingList of authors in order
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https://doi.org/10.1016/j.nbd.2023.106222Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.nbd.2023.106222Direct OA link when available
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Medicine, Internal medicine, Endocrinology, Angiotensin II, Pathophysiology of hypertension, Cardiology, Blood pressureTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2025: 8, 2024: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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