Dynamic configuration of large-scale cortical networks during an inhibitory task accounts for heterogeneity in attention-deficit/hyperactivity disorder traits Article Swipe
Jonah Kember
,
Carolynn Hare
,
Ayda Tekok-Kılıç
,
William Marshall
,
Stephen M. Emrich
,
Sidney J. Segalowitz
,
Erin J. Panda
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.08.04.455077
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.08.04.455077
The heterogeneity of attention-deficit/hyperactivity disorder (ADHD) traits (inattention vs. hyperactivity/impulsivity) complicates diagnosis and intervention. Identifying how the configuration of large-scale functional brain networks during cognitive processing correlate with this heterogeneity could help us understand the neural mechanisms altered across ADHD presentations. Here, we recorded high-density EEG while 62 non-clinical participants (ages 18-24; 32 male) underwent an inhibitory control task (Go/No-Go). Functional EEG networks were created using sensors as nodes and across-trial phase-lag index values as edges. Using cross-validated LASSO regression, we examined whether graph-theory metrics applied to both static networks (averaged across time-windows: -500–0ms, 0–500ms) and dynamic networks (temporally layered with 2ms intervals), were associated with hyperactive/impulsive and inattentive traits. Network configuration during response execution/inhibition was associated with hyperactive/impulsive (mean R 2 across test sets = .20, SE = .02), but not inattentive traits. Post-stimulus results at higher frequencies (Beta, 14-29Hz; Gamma, 30-90Hz) showed the strongest association with hyperactive/impulsive traits, and predominantly reflected less burst-like integration between modules in oscillatory beta networks during execution, and increased integration/small-worldness in oscillatory gamma networks during inhibition. We interpret the beta network results as reflecting weaker integration between specialized pre-frontal and motor systems during motor response preparation, and the gamma results as reflecting a compensatory mechanism used to integrate processing between less functionally specialized networks. This research demonstrates that the neural network mechanisms underlying response execution/inhibition might be associated with hyperactive/impulsive traits, and that dynamic, task-related changes in EEG functional networks may be useful in disentangling ADHD heterogeneity.
Related Topics
Concepts
Impulsivity
Psychology
Electroencephalography
Response inhibition
Neuroscience
Stimulus (psychology)
Phase lag
Cognition
Attention deficit hyperactivity disorder
Inhibitory control
Inhibitory postsynaptic potential
Audiology
Developmental psychology
Cognitive psychology
Medicine
Mathematics
Clinical psychology
Applied mathematics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.08.04.455077
- https://www.biorxiv.org/content/biorxiv/early/2021/08/05/2021.08.04.455077.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3192369301
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3192369301Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.08.04.455077Digital Object Identifier
- Title
-
Dynamic configuration of large-scale cortical networks during an inhibitory task accounts for heterogeneity in attention-deficit/hyperactivity disorder traitsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-05Full publication date if available
- Authors
-
Jonah Kember, Carolynn Hare, Ayda Tekok-Kılıç, William Marshall, Stephen M. Emrich, Sidney J. Segalowitz, Erin J. PandaList of authors in order
- Landing page
-
https://doi.org/10.1101/2021.08.04.455077Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/08/05/2021.08.04.455077.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/08/05/2021.08.04.455077.full.pdfDirect OA link when available
- Concepts
-
Impulsivity, Psychology, Electroencephalography, Response inhibition, Neuroscience, Stimulus (psychology), Phase lag, Cognition, Attention deficit hyperactivity disorder, Inhibitory control, Inhibitory postsynaptic potential, Audiology, Developmental psychology, Cognitive psychology, Medicine, Mathematics, Clinical psychology, Applied mathematicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1Per-year citation counts (last 5 years)
- References (count)
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83Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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