Dynamic of SOFA Score Predicts Functionality after ARDS Therapy Article Swipe
Alice Bernard
,
Lina María Serna‐Higuita
,
Peter Martus
,
Valbona Mirakaj
,
Michael Koeppen
,
Alexander Zarbock
,
Gernot Marx
,
Christian Putensen
,
Peter Rosenberger
,
Helene A. Haeberle
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2263925/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2263925/v1
Rationale : Health-related quality of life after surviving acute respiratory distress syndrome has come into focus in recent years, especially during the coronavirus disease 2019 pandemic. Objectives : A total of 143 patients with acute respiratory distress syndrome caused by COVID-19 or of other origin were recruited in a randomized multicenter trial. Methods : Clinical data during intensive care treatment and data up to 180 days after study inclusion were collected. Changes in the Sequential Organ Failure Assessment score were used to quantify disease severity. Disability was assessed using the Barthel index on days 1, 28, 90, and 180. Measurements : Mortality rate and morbidity after 180 days were compared between patients with and without COVID-19. Independent risk factors associated with high disability were identified using a binary logistic regression. Main Results : Mortality after 180 days and impairment measured by the Barthel index did not differ between patients with and without COVID-19. The SOFA score at day 5 was an independent risk factor for high disability in both groups, and score dynamic within the first 5 days significantly impacted disability in the non-COVID group. Conclusions : Acute respiratory distress syndrome caused by COVID-19 was not associated with increased mortality or morbidity. Resolution of organ dysfunction within the first 5 days significantly impacts long-term morbidity and emphasizes the importance of timely initiation of treatment in these critically ill patients.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-2263925/v1
- https://www.researchsquare.com/article/rs-2263925/latest.pdf
- OA Status
- green
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4309544409
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4309544409Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-2263925/v1Digital Object Identifier
- Title
-
Dynamic of SOFA Score Predicts Functionality after ARDS TherapyWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-11-21Full publication date if available
- Authors
-
Alice Bernard, Lina María Serna‐Higuita, Peter Martus, Valbona Mirakaj, Michael Koeppen, Alexander Zarbock, Gernot Marx, Christian Putensen, Peter Rosenberger, Helene A. HaeberleList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-2263925/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-2263925/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-2263925/latest.pdfDirect OA link when available
- Concepts
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Medicine, ARDS, SOFA score, Logistic regression, Severity of illness, Quality of life (healthcare), Internal medicine, Mortality rate, Distress, Physical therapy, Intensive care medicine, Intensive care unit, Lung, Nursing, Clinical psychologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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