Dynamic remodeling of septin structures fine-tunes myogenic differentiation Article Swipe
Vladimir Ugorets
,
Paul‐Lennard Mendez
,
Dmitrii Zagrebin
,
Giulia Russo
,
Yannic Kerkhoff
,
Georgios Kotsaris
,
Jerome Jatzlau
,
Sigmar Stricker
,
Petra Knaus
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.isci.2024.110630
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.isci.2024.110630
Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells. The transformation of proliferative muscle progenitors into multinuclear syncytia involves intricate cellular processes driven by cytoskeletal reorganization. While actin and microtubles have been extensively studied, we illuminate the role of septins, an essential yet still often overlooked cytoskeletal component, in myoblast architecture. Notably, Septin9 emerges as a critical regulator of myoblast differentiation during the initial commitment phase. Knock-down of Septin9 in C2C12 cells and primary mouse myoblasts accelerates the transition from proliferation to committed progenitor transcriptional programs. Furthermore, we unveil significant reorganization and downregulation of Septin9 during myogenic differentiation. Collectively, we propose that filmamentous septin structures and their orchestrated reorganization in myoblasts are part of a temporal regulatory mechanism governing the differentiation of myogenic progenitors. This study sheds light on the dynamic interplay between cytoskeletal components underlying controlled myogenic differentiation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.isci.2024.110630
- OA Status
- gold
- Cited By
- 2
- References
- 102
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401236584
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401236584Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.isci.2024.110630Digital Object Identifier
- Title
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Dynamic remodeling of septin structures fine-tunes myogenic differentiationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-07-31Full publication date if available
- Authors
-
Vladimir Ugorets, Paul‐Lennard Mendez, Dmitrii Zagrebin, Giulia Russo, Yannic Kerkhoff, Georgios Kotsaris, Jerome Jatzlau, Sigmar Stricker, Petra KnausList of authors in order
- Landing page
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https://doi.org/10.1016/j.isci.2024.110630Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.isci.2024.110630Direct OA link when available
- Concepts
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Cell biology, C2C12, Cytoskeleton, Progenitor cell, Myocyte, Septin, Biology, Cellular differentiation, Actin, Syncytium, Skeletal muscle, Stem cell, Regulator, Myogenesis, Cytokinesis, Cell division, Cell, Anatomy, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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102Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].score | 0.5 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.69482446 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |