Dynamics of diversified A-to-I editing inStreptococcus pyogenesis governed by changes in mRNA stability Article Swipe

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Thomas F. Wulff , Karin Hahnke , Anne-Laure Lécrivain , Katja Schmidt , Rina Ahmed-Begrich , Knut Finstermeier , Emmanuelle Charpentier ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1101/2023.09.19.555891

Adenosine-to-inosine (A-to-I) RNA editing plays an important role in the post-transcriptional regulation of eukaryotic cell physiology. However, our understanding of the occurrence, function and regulation of A-to-I editing in bacteria remains limited. Bacterial mRNA editing is catalysed by the deaminase TadA, which was originally described to modify a single tRNA in E. coli . Intriguingly, several bacterial species appear to perform A-to-I editing on more than one tRNA. Here, we provide evidence that in the human pathogen Streptococcus pyogenes , tRNA editing has expanded to an additional tRNA substrate. Using RNA sequencing, we identified more than 27 editing sites in the transcriptome of S. pyogenes SF370 and demonstrate that the adaptation of S. pyogenes TadA to a second tRNA substrate has also diversified the sequence context and recoding scope of mRNA editing. Based on the observation that editing is dynamically regulated in response to several infection-relevant stimuli, such as oxidative stress, we further investigated the underlying determinants of editing dynamics and identified mRNA stability as a key modulator of A-to-I editing. Overall, our findings reveal the presence and diversification of A-to-I editing in S. pyogenes and provide novel insights into the plasticity of the editome and its regulation in bacteria. GRAPHICAL ABSTRACT

Related Topics

Biology

Transfer Rna

Genome Editing

Streptococcus Pyogenes

Rna

Computational Biology

Staphylococcus Aureus

Concepts

RNA editing Biology Transfer RNA Inosine Genome editing Streptococcus pyogenes Transcriptome RNA Computational biology Context (archaeology) Translation (biology) Messenger RNA Function (biology) Genetics Gene Bacteria Gene expression Biochemistry CRISPR Enzyme Paleontology Staphylococcus aureus

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2023.09.19.555891
PDF: https://www.biorxiv.org/content/biorxiv/early/2023/09/19/2023.09.19.555891.full.pdf
OA Status: green
Cited By: 2
References: 88
Related Works: 10
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DOI: https://doi.org/10.1101/2023.09.19.555891

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Title: Dynamics of diversified A-to-I editing inStreptococcus pyogenesis governed by changes in mRNA stability

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Language: en

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Publication year: 2023

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Publication date: 2023-09-19

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Authors: Thomas F. Wulff, Karin Hahnke, Anne-Laure Lécrivain, Katja Schmidt, Rina Ahmed-Begrich, Knut Finstermeier, Emmanuelle Charpentier

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Landing page: https://doi.org/10.1101/2023.09.19.555891

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Concepts: RNA editing, Biology, Transfer RNA, Inosine, Genome editing, Streptococcus pyogenes, Transcriptome, RNA, Computational biology, Context (archaeology), Translation (biology), Messenger RNA, Function (biology), Genetics, Gene, Bacteria, Gene expression, Biochemistry, CRISPR, Enzyme, Paleontology, Staphylococcus aureus

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