Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development Article Swipe
Stephen B. Spurgin
,
Ange Michelle Nguimtsop
,
Fatima Chaudhry
,
Nigel S. Michki
,
Jocelynda Salvador
,
M. Luisa Iruela‐Arispe
,
Jarod A. Zepp
,
Saikat Mukhopadhyay
,
Ondine Cleaver
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/dvdy.70008
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/dvdy.70008
Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their critical role in the establishment of a left–right axis in early development is well described, as well as in the defense immune function of multiciliated upper airway epithelium. By contrast, detailed analysis of the ciliary status of specific cell types during organogenesis and postnatal development has received less attention. In this study, we investigate the progression of ciliary status within the endothelium and mesenchyme of the lung. Remarkably, we find that pulmonary endothelial cells (ECs) lack PC at all stages of development, except in low numbers in the proximal portions of older pulmonary arteries. Mesenchymal cells, by contrast, widely exhibit PC in early development, and a large subset of PDGFRα+ fibroblasts maintain PC into adulthood. The dynamic and differential ciliation of multiple cellular populations in the developing lung both challenges prior assertions that PC are found on all cells and highlights a need to understand their spatiotemporal functions.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/dvdy.70008
- OA Status
- green
- Cited By
- 4
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408301724
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4408301724Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/dvdy.70008Digital Object Identifier
- Title
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Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung developmentWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
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2025Year of publication
- Publication date
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2025-03-08Full publication date if available
- Authors
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Stephen B. Spurgin, Ange Michelle Nguimtsop, Fatima Chaudhry, Nigel S. Michki, Jocelynda Salvador, M. Luisa Iruela‐Arispe, Jarod A. Zepp, Saikat Mukhopadhyay, Ondine CleaverList of authors in order
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https://doi.org/10.1002/dvdy.70008Publisher landing page
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/12353473Direct OA link when available
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Cilium, Biology, Mesenchyme, Cell biology, Mesenchymal stem cell, Lung, Endothelium, Morphogenesis, Immunology, Internal medicine, Endocrinology, Genetics, Medicine, GeneTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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