Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel Article Swipe
Eman Sayed Mohammed
,
Risa Nakamura
,
Dan Justin Kalenda Yombo
,
Sharmina Deloer
,
Taeko Moriyasu
,
Mio Tanaka
,
Yoshito Fujii
,
Satoshi Kaneko
,
Kenji Hirayama
,
Ahmed I. Ibrahim
,
Mahmoud A. El-Seify
,
Asmaa M. Metwally
,
Shinjiro Hamano
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pntd.0008518
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pntd.0008518
To eliminate schistosomiasis, appropriate diagnostic tests are required to monitor its prevalence and transmission, especially in the settings with low endemicity resulting from the consecutive mass drug administration. Antibodies that react with either crude soluble schistosome egg antigens or soluble worm antigen preparations have been used to monitor infection in low-prevalence regions. However, these detection methods cannot discriminate current and past infections and are cross-reactive with other parasites because both antigens contain numerous proteins and glycans from schistosomes, and standard preparations need maintenance of the life cycle of the schistosome. To evaluate the potential utility of nine recombinant Schistosoma mansoni proteins as single defined antigens for serological diagnosis, we monitored the kinetics of antibodies to each antigen during S. mansoni infection in mice before and after the treatment with praziquantel. C57BL/6 mice were infected with 50 cercariae. The levels of immunoglobulin G (IgG) raised against five recombinant antigens (RP26, sm31, sm32, GST, and LAP1) significantly increased as early as 2-4 weeks after infection and rapidly declined by 2 weeks after the treatment, whereas those raised against crude S. mansoni egg antigens or other antigens remained elevated long after the treatment. The IgG1 raised against RP26, sm31, and serpin decreased after the treatment with praziquantel, whereas the IgE raised against serpin declined strikingly after the treatment. This study clarifies the dynamics of the serological responses to recombinant S. mansoni proteins during infection and after the treatment with praziquantel and identifies several candidate antigens with potential utility in the monitoring and surveillance of schistosomiasis toward the elimination of schistosomiasis.
Related Topics
Concepts
Schistosoma mansoni
Praziquantel
Antigen
Schistosomiasis
Immunology
Serology
Biology
Antibody
Immunogenicity
Schistosoma
Recombinant DNA
Virology
Immunoglobulin E
Immunoglobulin G
Helminths
Gene
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pntd.0008518
- https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008518&type=printable
- OA Status
- gold
- Cited By
- 8
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3086023189
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3086023189Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pntd.0008518Digital Object Identifier
- Title
-
Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantelWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-09-11Full publication date if available
- Authors
-
Eman Sayed Mohammed, Risa Nakamura, Dan Justin Kalenda Yombo, Sharmina Deloer, Taeko Moriyasu, Mio Tanaka, Yoshito Fujii, Satoshi Kaneko, Kenji Hirayama, Ahmed I. Ibrahim, Mahmoud A. El-Seify, Asmaa M. Metwally, Shinjiro HamanoList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pntd.0008518Publisher landing page
- PDF URL
-
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008518&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008518&type=printableDirect OA link when available
- Concepts
-
Schistosoma mansoni, Praziquantel, Antigen, Schistosomiasis, Immunology, Serology, Biology, Antibody, Immunogenicity, Schistosoma, Recombinant DNA, Virology, Immunoglobulin E, Immunoglobulin G, Helminths, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2023: 1, 2022: 1, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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