Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion Article Swipe
Felix J. Eppler
,
Thomas Quast
,
Waldemar Kolanus
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0172443
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0172443
Leukocyte trafficking is crucial to facilitate efficient immune responses. Here, we report that the large GTPase dynamin2, which is generally considered to have a key role in endocytosis and membrane remodeling, is an essential regulator of integrin-dependent human T lymphocyte adhesion and migration. Chemical inhibition or knockdown of dynamin2 expression significantly reduced integrin-dependent T cell adhesion in vitro. This phenotype was not observed when T cells were treated with various chemical inhibitors which abrogate endocytosis or actin polymerization. We furthermore detected dynamin2 in signaling complexes and propose that it controls T cell adhesion via FAK/Pyk2- and RapGEF1-mediated Rap1 activation. In addition, the dynamin2 inhibitor-induced reduction of lymphocyte adhesion can be rescued by Rap1a overexpression. We demonstrate that the dynamin2 effect on T cell adhesion does not involve integrin affinity regulation but instead relies on its ability to modulate integrin valency. Taken together, we suggest a previously unidentified role of dynamin2 in the regulation of integrin-mediated lymphocyte adhesion via a Rap1 signaling pathway.
Related Topics
Concepts
Cell biology
Rap1
Integrin
Cell adhesion
Endocytosis
Integrin, beta 6
Biology
Adhesion
CD49c
Collagen receptor
Chemistry
Signal transduction
Cell
Biochemistry
Organic chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0172443
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172443&type=printable
- OA Status
- gold
- Cited By
- 9
- References
- 88
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2592727452
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2592727452Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0172443Digital Object Identifier
- Title
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Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-03-08Full publication date if available
- Authors
-
Felix J. Eppler, Thomas Quast, Waldemar KolanusList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0172443Publisher landing page
- PDF URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172443&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172443&type=printableDirect OA link when available
- Concepts
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Cell biology, Rap1, Integrin, Cell adhesion, Endocytosis, Integrin, beta 6, Biology, Adhesion, CD49c, Collagen receptor, Chemistry, Signal transduction, Cell, Biochemistry, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1, 2022: 3, 2021: 2, 2019: 2, 2018: 1Per-year citation counts (last 5 years)
- References (count)
-
88Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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