Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus Article Swipe
Haiyan Zhou
,
Bojiang Li
,
Jing Li
,
Tongqian Wu
,
Xiaoqian Jin
,
Rui Yuan
,
Ping Shi
,
Yan Zhou
,
Long Li
,
Fang Yu
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1155/2019/8450947
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1155/2019/8450947
Accumulating evidence indicates a critical role for T cells and relevant cytokines in the pathogenesis of systemic lupus erythematosus (SLE). However, the specific contribution of T cells together with the related circulating cytokines in disease pathogenesis and organ involvement is still not clear. In the current study, we investigated relevant molecule expressions and cytokine levels in blood samples from 49 SLE patients and 22 healthy control subjects. The expression of HLA-DR and costimulatory molecules on T cells was evaluated by flow cytometry. Concentrations of serum C-reactive protein, erythrocyte sedimentation rate, anti-double-stranded DNA (anti-dsDNA) antibody, total lgG, complement 3, and complement 4 were measured. Serum cytokines and chemokines were measured by a cytometric bead array assay. Elevated frequencies of HLA-DR + T cells and ICOS + T cells were observed in SLE patients with positive anti-dsDNA antibodies compared with those in healthy controls (). The expression of HLA-DR + T cells was positively correlated with SLEDAI (, ). Furthermore, levels of serum IL-6, MCP-1, TNFRI, IL-10, IL-12, and CCL20 were higher in SLE patients compared with healthy controls. In addition, patients with hematologic manifestations displayed elevated frequencies of HLA-DR + T cells and ICOS + T cells. Patients with renal manifestations had a decreased frequency of TIGIT + T cells. These results suggested a dysregulated T cell activity and cytokine expression profiles in SLE subjects. We also developed a chemokine and cytokine profiling strategy to predict the activity of SLE, which has clinical implication for better monitoring the flares and remission during the course of SLE and for assessing therapeutic interventions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2019/8450947
- https://downloads.hindawi.com/journals/mi/2019/8450947.pdf
- OA Status
- gold
- Cited By
- 46
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2921842588
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2921842588Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1155/2019/8450947Digital Object Identifier
- Title
-
Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus ErythematosusWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-03-17Full publication date if available
- Authors
-
Haiyan Zhou, Bojiang Li, Jing Li, Tongqian Wu, Xiaoqian Jin, Rui Yuan, Ping Shi, Yan Zhou, Long Li, Fang YuList of authors in order
- Landing page
-
https://doi.org/10.1155/2019/8450947Publisher landing page
- PDF URL
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https://downloads.hindawi.com/journals/mi/2019/8450947.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://downloads.hindawi.com/journals/mi/2019/8450947.pdfDirect OA link when available
- Concepts
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Immunology, Cytokine, Medicine, Lupus erythematosus, Systemic lupus erythematosus, Antibody, Pathology, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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46Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 10, 2023: 10, 2022: 11, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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30Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.on | 74 |
| abstract_inverted_index.to | 239 |
| abstract_inverted_index.we | 47 |
| abstract_inverted_index.DNA | 91 |
| abstract_inverted_index.SLE | 60, 130, 177, 228, 260 |
| abstract_inverted_index.The | 67, 145 |
| abstract_inverted_index.and | 9, 36, 52, 62, 71, 98, 105, 122, 172, 197, 223, 235, 254, 261 |
| abstract_inverted_index.for | 6, 249, 262 |
| abstract_inverted_index.had | 206 |
| abstract_inverted_index.has | 246 |
| abstract_inverted_index.not | 41 |
| abstract_inverted_index.the | 13, 21, 29, 44, 241, 252, 257 |
| abstract_inverted_index.was | 77, 152 |
| abstract_inverted_index.ICOS | 123, 198 |
| abstract_inverted_index.SLE, | 244 |
| abstract_inverted_index.also | 231 |
| abstract_inverted_index.bead | 112 |
| abstract_inverted_index.cell | 221 |
| abstract_inverted_index.flow | 80 |
| abstract_inverted_index.from | 58 |
| abstract_inverted_index.lgG, | 95 |
| abstract_inverted_index.role | 5 |
| abstract_inverted_index.were | 101, 107, 127, 174 |
| abstract_inverted_index.with | 28, 132, 137, 155, 180, 186, 203 |
| abstract_inverted_index.CCL20 | 173 |
| abstract_inverted_index.IL-6, | 167 |
| abstract_inverted_index.Serum | 103 |
| abstract_inverted_index.TIGIT | 211 |
| abstract_inverted_index.These | 215 |
| abstract_inverted_index.array | 113 |
| abstract_inverted_index.blood | 56 |
| abstract_inverted_index.cells | 8, 26, 76, 121, 126, 151, 196 |
| abstract_inverted_index.lupus | 17 |
| abstract_inverted_index.organ | 37 |
| abstract_inverted_index.rate, | 89 |
| abstract_inverted_index.renal | 204 |
| abstract_inverted_index.serum | 84, 166 |
| abstract_inverted_index.still | 40 |
| abstract_inverted_index.those | 138 |
| abstract_inverted_index.total | 94 |
| abstract_inverted_index.which | 245 |
| abstract_inverted_index.(SLE). | 19 |
| abstract_inverted_index.HLA-DR | 70, 118, 148, 193 |
| abstract_inverted_index.IL-10, | 170 |
| abstract_inverted_index.IL-12, | 171 |
| abstract_inverted_index.MCP-1, | 168 |
| abstract_inverted_index.SLEDAI | 156 |
| abstract_inverted_index.TNFRI, | 169 |
| abstract_inverted_index.assay. | 114 |
| abstract_inverted_index.better | 250 |
| abstract_inverted_index.cells. | 201, 214 |
| abstract_inverted_index.clear. | 42 |
| abstract_inverted_index.course | 258 |
| abstract_inverted_index.during | 256 |
| abstract_inverted_index.flares | 253 |
| abstract_inverted_index.higher | 175 |
| abstract_inverted_index.levels | 54, 164 |
| abstract_inverted_index.study, | 46 |
| abstract_inverted_index.control | 65 |
| abstract_inverted_index.current | 45 |
| abstract_inverted_index.disease | 34 |
| abstract_inverted_index.healthy | 64, 140, 181 |
| abstract_inverted_index.predict | 240 |
| abstract_inverted_index.related | 30 |
| abstract_inverted_index.results | 216 |
| abstract_inverted_index.samples | 57 |
| abstract_inverted_index.Elevated | 115 |
| abstract_inverted_index.However, | 20 |
| abstract_inverted_index.Patients | 202 |
| abstract_inverted_index.activity | 222, 242 |
| abstract_inverted_index.clinical | 247 |
| abstract_inverted_index.compared | 136, 179 |
| abstract_inverted_index.controls | 141 |
| abstract_inverted_index.critical | 4 |
| abstract_inverted_index.cytokine | 53, 224, 236 |
| abstract_inverted_index.elevated | 190 |
| abstract_inverted_index.evidence | 1 |
| abstract_inverted_index.measured | 108 |
| abstract_inverted_index.molecule | 50 |
| abstract_inverted_index.observed | 128 |
| abstract_inverted_index.patients | 61, 131, 178, 185 |
| abstract_inverted_index.positive | 133 |
| abstract_inverted_index.profiles | 226 |
| abstract_inverted_index.protein, | 86 |
| abstract_inverted_index.relevant | 10, 49 |
| abstract_inverted_index.specific | 22 |
| abstract_inverted_index.strategy | 238 |
| abstract_inverted_index.systemic | 16 |
| abstract_inverted_index.together | 27 |
| abstract_inverted_index.<mml:math | 160 |
| abstract_inverted_index.addition, | 184 |
| abstract_inverted_index.antibody, | 93 |
| abstract_inverted_index.assessing | 263 |
| abstract_inverted_index.chemokine | 234 |
| abstract_inverted_index.controls. | 182 |
| abstract_inverted_index.cytokines | 11, 32, 104 |
| abstract_inverted_index.decreased | 208 |
| abstract_inverted_index.developed | 232 |
| abstract_inverted_index.displayed | 189 |
| abstract_inverted_index.evaluated | 78 |
| abstract_inverted_index.frequency | 209 |
| abstract_inverted_index.indicates | 2 |
| abstract_inverted_index.measured. | 102 |
| abstract_inverted_index.molecules | 73 |
| abstract_inverted_index.profiling | 237 |
| abstract_inverted_index.remission | 255 |
| abstract_inverted_index.subjects. | 66, 229 |
| abstract_inverted_index.suggested | 217 |
| abstract_inverted_index.(<mml:math | 142, 157 |
| abstract_inverted_index.C-reactive | 85 |
| abstract_inverted_index.anti-dsDNA | 134 |
| abstract_inverted_index.antibodies | 135 |
| abstract_inverted_index.chemokines | 106 |
| abstract_inverted_index.complement | 96, 99 |
| abstract_inverted_index.correlated | 154 |
| abstract_inverted_index.cytometric | 111 |
| abstract_inverted_index.cytometry. | 81 |
| abstract_inverted_index.expression | 68, 146, 225 |
| abstract_inverted_index.monitoring | 251 |
| abstract_inverted_index.positively | 153 |
| abstract_inverted_index.circulating | 31 |
| abstract_inverted_index.erythrocyte | 87 |
| abstract_inverted_index.expressions | 51 |
| abstract_inverted_index.frequencies | 116, 191 |
| abstract_inverted_index.hematologic | 187 |
| abstract_inverted_index.implication | 248 |
| abstract_inverted_index.involvement | 38 |
| abstract_inverted_index.therapeutic | 264 |
| abstract_inverted_index.(anti-dsDNA) | 92 |
| abstract_inverted_index.Accumulating | 0 |
| abstract_inverted_index.Furthermore, | 163 |
| abstract_inverted_index.contribution | 23 |
| abstract_inverted_index.dysregulated | 219 |
| abstract_inverted_index.investigated | 48 |
| abstract_inverted_index.pathogenesis | 14, 35 |
| abstract_inverted_index.costimulatory | 72 |
| abstract_inverted_index.erythematosus | 18 |
| abstract_inverted_index.sedimentation | 88 |
| abstract_inverted_index.Concentrations | 82 |
| abstract_inverted_index.interventions. | 265 |
| abstract_inverted_index.manifestations | 188, 205 |
| abstract_inverted_index.anti-double-stranded | 90 |
| abstract_inverted_index.xmlns:mml="http://www.w3.org/1998/Math/MathML" | 143, 158, 161 |
| abstract_inverted_index.id="M2"><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.15</mml:mn></mml:math>, | 159 |
| abstract_inverted_index.id="M3"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.01</mml:mn></mml:math>). | 162 |
| abstract_inverted_index.id="M1"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>). | 144 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5065076327 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I149137203, https://openalex.org/I4210109381 |
| citation_normalized_percentile.value | 0.94138911 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |