Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer Article Swipe
Charles C. Guo
,
Tadeusz Majewski
,
Li Zhang
,
Hui Yao
,
Jolanta Bondaruk
,
Yan Wang
,
Shizhen Zhang
,
Ziqiao Wang
,
June Goo Lee
,
Sangkyou Lee
,
David Cogdell
,
Miao Zhang
,
Peng Wei
,
H. Barton Grossman
,
Ashish M. Kamat
,
Jonathan J. Duplisea
,
James E. Ferguson
,
He Huang
,
Vipulkumar Dadhania
,
Colin P. Dinney
,
John N. Weinstein
,
Keith Baggerly
,
David J. McConkey
,
Bogdan Czerniak
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1101/388264
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1101/388264
SUMMARY The sarcomatoid variant of urothelial bladder cancer (SARC) displays a high propensity for distant metastasis and is associated with short survival. We report a comprehensive genomic analysis of 28 cases of SARCs and 84 cases of conventional urothelial carcinomas (UCs), with the TCGA cohort of 408 muscle-invasive bladder cancers serving as the reference. SARCs showed a distinct mutational landscape with enrichment of TP53, RB1, and PIK3CA mutations. They were related to the basal molecular subtype of conventional UCs and could be divided into epithelial/basal and more clinically aggressive mesenchymal subsets based on TP63 and its target genes expression levels. Other analyses revealed that SARCs are driven by downregulation of homotypic adherence genes and dysregulation of cell cycle and EMT networks, and nearly half exhibited a heavily infiltrated immune phenotype. Our observations have important implications for prognostication and the development of more effective therapies for this highly lethal variant of bladder cancer.
Related Topics
Concepts
Bladder cancer
Downregulation and upregulation
Urothelial cancer
Metastasis
Cancer research
Cancer
Basal (medicine)
Phenotype
Gene
Biology
Epithelial–mesenchymal transition
Medicine
Oncology
Internal medicine
Genetics
Insulin
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/388264
- https://www.biorxiv.org/content/biorxiv/early/2018/08/09/388264.full.pdf
- OA Status
- green
- Cited By
- 21
- References
- 71
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2885324351
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2885324351Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/388264Digital Object Identifier
- Title
-
Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder CancerWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-08-09Full publication date if available
- Authors
-
Charles C. Guo, Tadeusz Majewski, Li Zhang, Hui Yao, Jolanta Bondaruk, Yan Wang, Shizhen Zhang, Ziqiao Wang, June Goo Lee, Sangkyou Lee, David Cogdell, Miao Zhang, Peng Wei, H. Barton Grossman, Ashish M. Kamat, Jonathan J. Duplisea, James E. Ferguson, He Huang, Vipulkumar Dadhania, Colin P. Dinney, John N. Weinstein, Keith Baggerly, David J. McConkey, Bogdan CzerniakList of authors in order
- Landing page
-
https://doi.org/10.1101/388264Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2018/08/09/388264.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2018/08/09/388264.full.pdfDirect OA link when available
- Concepts
-
Bladder cancer, Downregulation and upregulation, Urothelial cancer, Metastasis, Cancer research, Cancer, Basal (medicine), Phenotype, Gene, Biology, Epithelial–mesenchymal transition, Medicine, Oncology, Internal medicine, Genetics, InsulinTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
21Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 6, 2023: 2, 2021: 5, 2020: 6Per-year citation counts (last 5 years)
- References (count)
-
71Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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